PD184352
- Product Name
- PD184352
- CAS No.
- 212631-79-3
- Chemical Name
- PD184352
- Synonyms
- CS-333;Ci-1040;PD184352;PD 184352, >=98%;CI-1040, PD-184352;PD184352 USP/EP/BP;PD 184352;CI-1040;PD-184352;CI1040;PD-184352; CI 1040 (PD184352);2-[(2-CHLORO-4-IODOPHENYL) AMINO]-N-(CYCLOPROPYLME;2-(2-CHLORO-4-IODOANILINO)-N-(CYCLOPROPYLMETHOXY)-3,4-DIFLUOROBENZAMIDE
- CBNumber
- CB1500875
- Molecular Formula
- C17H14ClF2IN2O2
- Formula Weight
- 478.66
- MOL File
- 212631-79-3.mol
PD184352 Property
- Melting point:
- 166-169°C
- Density
- 1.747±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: ≥30mg/mL
- pka
- -5.58±0.50(Predicted)
- form
- powder
- color
- white to tan
N-Bromosuccinimide Price
- Product number
- PZ0181
- Product name
- PD 184352
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $129
- Updated
- 2024/03/01
- Product number
- PZ0181
- Product name
- PD 184352
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $516
- Updated
- 2024/03/01
- Product number
- P2174
- Product name
- PD 184352
- Packaging
- 25MG
- Price
- $243
- Updated
- 2024/03/01
- Product number
- P2174
- Product name
- PD 184352
- Packaging
- 100MG
- Price
- $726
- Updated
- 2024/03/01
- Product number
- 11580
- Product name
- CI-1040
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
PD184352 Chemical Properties,Usage,Production
Chemical Properties
Off-White to Pale Beige Solid
Uses
An inhibitor of ERK signaling pathway. A MAP kinase inhibitor. Potent MEK inhibitor.
Definition
ChEBI: 2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide is an aminobenzoic acid.
Biological Activity
pd184352 (also known as ci-1040), a benzhydroxamate derivative, is a potent and highly selective mek1/2, two members of the family of mapkks, inhibitor that inhibits purified mek1 with ic50 of 17 nm in a non-atp and non-erk1/2 competitive manner [1].pd184352 binds to a hydrophobic pocket, which is located in a region with low sequence homology to other kinases, adjacent to the mg-atp binding site of mek1 and mek2 inducing a conformational change in un-phosphorylated mek1/2 and hence inactivating the un-phosphorylated mek1/2 [1].pd184352 has been found to be actively against tumors, where it inhibits the growth of colon carcinomas in mouse xenograft models [1].
Biochem/physiol Actions
PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2. It has anti-cancer activity, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell lines.
storage
Store at +4°C
References
[1] frémin c, meloche s. from basic research to clinical development of mek1/2 inhibitors for cancer therapy. j hematol oncol. 2010 feb 11;3:8. doi: 10.1186/1756-8722-3-8.
PD184352 Preparation Products And Raw materials
Raw materials
Preparation Products
PD184352 Suppliers
View Lastest Price from PD184352 manufacturers
- Product
- PD184352 212631-79-3
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-24