PD184352

Product Name: PD184352
CAS No.: 212631-79-3
Chemical Name: PD184352
Synonyms: CS-333;Ci-1040;PD184352;PD 184352, >=98%;CI-1040, PD-184352;PD184352 USP/EP/BP;PD 184352;CI-1040;PD-184352;CI1040;PD-184352; CI 1040 (PD184352);2-[(2-CHLORO-4-IODOPHENYL) AMINO]-N-(CYCLOPROPYLME;2-(2-CHLORO-4-IODOANILINO)-N-(CYCLOPROPYLMETHOXY)-3,4-DIFLUOROBENZAMIDE
CBNumber: CB1500875
Molecular Formula: C17H14ClF2IN2O2
Formula Weight: 478.66
MOL File: 212631-79-3.mol

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PD184352 Property

Melting point:: 166-169°C
Density: 1.747±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: ≥30mg/mL
pka: -5.58±0.50(Predicted)
form: powder
color: white to tan

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Safety

Hazard Codes: N
Risk Statements: 50/53
Safety Statements: 60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H400Very toxic to aquatic life
Precautionary statements: P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0181
Product name: PD 184352
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $129
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0181
Product name: PD 184352
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $516
Updated: 2024/03/01

TCI Chemical

Product number: P2174
Product name: PD 184352
Packaging: 25MG
Price: $243
Updated: 2024/03/01

TCI Chemical

Product number: P2174
Product name: PD 184352
Packaging: 100MG
Price: $726
Updated: 2024/03/01

Cayman Chemical

Product number: 11580
Product name: CI-1040
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

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PD184352 Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Beige Solid

Uses

An inhibitor of ERK signaling pathway. A MAP kinase inhibitor. Potent MEK inhibitor.

Definition

ChEBI: 2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide is an aminobenzoic acid.

Biological Activity

pd184352 (also known as ci-1040), a benzhydroxamate derivative, is a potent and highly selective mek1/2, two members of the family of mapkks, inhibitor that inhibits purified mek1 with ic50 of 17 nm in a non-atp and non-erk1/2 competitive manner [1].pd184352 binds to a hydrophobic pocket, which is located in a region with low sequence homology to other kinases, adjacent to the mg-atp binding site of mek1 and mek2 inducing a conformational change in un-phosphorylated mek1/2 and hence inactivating the un-phosphorylated mek1/2 [1].pd184352 has been found to be actively against tumors, where it inhibits the growth of colon carcinomas in mouse xenograft models [1].

Biochem/physiol Actions

PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2. It has anti-cancer activity, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell lines.

storage

Store at +4°C

References

[1] frémin c, meloche s. from basic research to clinical development of mek1/2 inhibitors for cancer therapy. j hematol oncol. 2010 feb 11;3:8. doi: 10.1186/1756-8722-3-8.

PD184352 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD184352 Suppliers

Canada 1 China 110 Germany 1 India 3 Japan 1 The Netherlands 1 United Kingdom 4 United States 25 Global 146

Shanghai Boyle Chemical Co., Ltd.

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Jinan Trio PharmaTech Co., Ltd.

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Dalian Meilun Biotech Co., Ltd.

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Beijing HuaMeiHuLiBiological Chemical

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View Lastest Price from PD184352 manufacturers

Career Henan Chemical Co

Product: PD184352 212631-79-3
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-24

212631-79-3, PD184352Related Search:

PD318088 CHLOROPHENYLSILANE 97 Phenyl carbamate Selumetinib Trametinib SB 203580 LY 294002 HYDROCHLORIDE CHIR-99021 Rapamycin PD 98059 PD 166793 PD 0325901 PD173955 PD 166285 2-Chloro-4-iodoaniline 1-Chloro-3-iodobenzene CYCLOPROPYL METHOXYLAMINE HYDROCHLORIDE PD184352 (CI-1040)

CI1040;PD-184352; CI 1040 (PD184352)

CS-333

PD184352

2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide

2-(2-CHLORO-4-IODOANILINO)-N-(CYCLOPROPYLMETHOXY)-3,4-DIFLUOROBENZAMIDE

2-[(2-CHLORO-4-IODOPHENYL) AMINO]-N-(CYCLOPROPYLME

Benzamide, 2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-

Ci-1040

CI-1040, PD-184352

PD 184352;CI-1040;PD-184352

3,4-Difluoro-2-(2-chloro-4-iodophenylaMino)-N-cyclopropylMethoxybenzaMide

2-(2-Chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide PD184352

CI-10402-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide

PD 184352, >=98%

PD184352 USP/EP/BP

212631-79-3

C17H14ClF2IN2O2

Anti-cancer&immunity

MAPK

Pfizer compounds

Amines

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

Inhibitors

All Inhibitors