Meclizine Dihydrochloride Monohydrate
- Product Name
- Meclizine Dihydrochloride Monohydrate
- CAS No.
- 31884-77-2
- Chemical Name
- Meclizine Dihydrochloride Monohydrate
- Synonyms
- Permesin;Antivert;Meclizine hydrochloride;Meclizine Hydrochloride API;Meclizine Related CoMpound B;MECLIZINE HYDROCHLORIDE (500 MG);Meclizine Hydrochloride (1377009);MECLIZINE HYDROCHLORIDE MONOHYDRATE;Meclozine hydrochloride monohydrate;Meclizine dihydrochloride monohydrate
- CBNumber
- CB1501443
- Molecular Formula
- C25H27ClN2.2ClH.H2O
- Formula Weight
- 481.892
- MOL File
- 31884-77-2.mol
Meclizine Dihydrochloride Monohydrate Property
- Melting point:
- 210-213°C
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White
- Water Solubility
- Insoluble in water.
- CAS DataBase Reference
- 31884-77-2
Safety
- TSCA
- Yes
- HS Code
- 2933599550
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- J62464
- Product name
- Meclizine dihydrochloride monohydrate
- Packaging
- 1g
- Price
- $0
- Updated
- 2021/12/16
- Product number
- J62464
- Product name
- Meclizine dihydrochloride monohydrate
- Packaging
- 5g
- Price
- $0
- Updated
- 2021/12/16
- Product number
- J62464
- Product name
- Meclizine dihydrochloride monohydrate
- Packaging
- 10g
- Price
- $0
- Updated
- 2021/12/16
- Product number
- 281960
- Product name
- Meclizine dihydrochloride monohydrate
- Packaging
- 5g
- Price
- $403
- Updated
- 2021/12/16
- Product number
- M202700
- Product name
- Meclizine dihydrochloride monohydrate
- Packaging
- 5g
- Price
- $95
- Updated
- 2021/12/16
Meclizine Dihydrochloride Monohydrate Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
Antivert,Roerig,US,1957
Uses
Antiemetic and H1-histamine receptor antagonistMeclizine dihydrochloride monohydrate acts as an antiemetic. It is also used for the prevention and treatment of nausea during pregnancy. In addition to this, it is used in radiation sickness, vomiting or dizziness associated with motion sickness. Product purchased here is only for use in Research and Development.
Uses
Meclizine Dihydrochloride Monohydrate is used for the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.
Definition
ChEBI: Meclizine hydrochloride is a diarylmethane.
Manufacturing Process
32.3 g of 1-p-chlorobenzhydryl-4-benzyl-piperazine, dissolved in 300 cm3 of alcohol are heated in an autoclave vessel, in the presence of Raney nickel, under a pressure of 100 kg H2, at about 150°C for 6 hours. The catalyst is filtered, the solvent is evaporated and the residue is fractionated under a high vacuum. p-Chlorobenzylhydryl-piperazine (BP 180° to 185°C/1 mm Hg) is isolated with a yield of 75%. Then finely ground NaNH2 is added. The mixture is heated under reflux for 1 hour, the mass is cooled and a molar equivalent of m-methyl benzyl chloride is added.
The solvent is evaporated and the residue is dissolved in chloroform. This
solution is washed with a saturated solution of K2CO3 and dried on K2CO3. The
solvent is evaporated and the residue is distilled under high vacuum. The
product of the condensation distills near 230°C at 2 mm Hg pressure and the
corresponding dihydrochloride melts at 217° to 224°C.
brand name
Antivert (Pfizer).
Therapeutic Function
Antinauseant
General Description
Meclizine hydrochloride,1-(p-chloro-α-phenylbenzyl)-4-(m-methylbenzyl)piperazinedihydrochloride monohydrate (Bonine, Antivert), is atasteless, white or slightly yellowish crystalline powder that is practically insoluble in water (1:1,000). It differs fromchlorcyclizine in having an N-m-methylbenzyl group inplace of the N-methyl group. Although it is a moderately potentantihistaminic, meclizine is used primarily as an antinauseantin the prevention and treatment of motion sicknessand in the treatment of nausea and vomiting associated withvertigo.
Meclizine Dihydrochloride Monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Meclizine Dihydrochloride Monohydrate manufacturers
- Product
- Meclizine Dihydrochloride Monohydrate 31884-77-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-99.9%
- Supply Ability
- 200KG
- Release date
- 2020-01-07