Meclizine Dihydrochloride Monohydrate

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Meclizine Dihydrochloride Monohydrate

Product Name: Meclizine Dihydrochloride Monohydrate
CAS No.: 31884-77-2
Chemical Name: Meclizine Dihydrochloride Monohydrate
Synonyms: Permesin;Antivert;Meclizine hydrochloride;Meclizine Hydrochloride API;Meclizine Related CoMpound B;MECLIZINE HYDROCHLORIDE (500 MG);Meclizine Hydrochloride (1377009);MECLIZINE HYDROCHLORIDE MONOHYDRATE;Meclozine hydrochloride monohydrate;Meclizine dihydrochloride monohydrate
CBNumber: CB1501443
Molecular Formula: C25H27ClN2.2ClH.H2O
Formula Weight: 481.892
MOL File: 31884-77-2.mol

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Meclizine Dihydrochloride Monohydrate Property

Melting point:: 210-213°C
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White
Water Solubility: Insoluble in water.
CAS DataBase Reference: 31884-77-2

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Safety

TSCA: Yes
HS Code: 2933599550

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J62464
Product name: Meclizine dihydrochloride monohydrate
Packaging: 1g
Price: $0
Updated: 2021/12/16

Alfa Aesar

Product number: J62464
Product name: Meclizine dihydrochloride monohydrate
Packaging: 5g
Price: $0
Updated: 2021/12/16

Alfa Aesar

Product number: J62464
Product name: Meclizine dihydrochloride monohydrate
Packaging: 10g
Price: $0
Updated: 2021/12/16

Usbiological

Product number: 281960
Product name: Meclizine dihydrochloride monohydrate
Packaging: 5g
Price: $403
Updated: 2021/12/16

TRC

Product number: M202700
Product name: Meclizine dihydrochloride monohydrate
Packaging: 5g
Price: $95
Updated: 2021/12/16

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Meclizine Dihydrochloride Monohydrate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Antivert,Roerig,US,1957

Uses

Antiemetic and H1-histamine receptor antagonistMeclizine dihydrochloride monohydrate acts as an antiemetic. It is also used for the prevention and treatment of nausea during pregnancy. In addition to this, it is used in radiation sickness, vomiting or dizziness associated with motion sickness. Product purchased here is only for use in Research and Development.

Uses

Meclizine Dihydrochloride Monohydrate is used for the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.

Definition

ChEBI: Meclizine hydrochloride is a diarylmethane.

Manufacturing Process

32.3 g of 1-p-chlorobenzhydryl-4-benzyl-piperazine, dissolved in 300 cm3 of alcohol are heated in an autoclave vessel, in the presence of Raney nickel, under a pressure of 100 kg H2, at about 150°C for 6 hours. The catalyst is filtered, the solvent is evaporated and the residue is fractionated under a high vacuum. p-Chlorobenzylhydryl-piperazine (BP 180° to 185°C/1 mm Hg) is isolated with a yield of 75%. Then finely ground NaNH2 is added. The mixture is heated under reflux for 1 hour, the mass is cooled and a molar equivalent of m-methyl benzyl chloride is added.
The solvent is evaporated and the residue is dissolved in chloroform. This solution is washed with a saturated solution of K2CO3 and dried on K2CO3. The solvent is evaporated and the residue is distilled under high vacuum. The product of the condensation distills near 230°C at 2 mm Hg pressure and the corresponding dihydrochloride melts at 217° to 224°C.

brand name

Antivert (Pfizer).

Therapeutic Function

Antinauseant

General Description

Meclizine hydrochloride,1-(p-chloro-α-phenylbenzyl)-4-(m-methylbenzyl)piperazinedihydrochloride monohydrate (Bonine, Antivert), is atasteless, white or slightly yellowish crystalline powder that is practically insoluble in water (1:1,000). It differs fromchlorcyclizine in having an N-m-methylbenzyl group inplace of the N-methyl group. Although it is a moderately potentantihistaminic, meclizine is used primarily as an antinauseantin the prevention and treatment of motion sicknessand in the treatment of nausea and vomiting associated withvertigo.

Meclizine Dihydrochloride Monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Meclizine Dihydrochloride Monohydrate manufacturers

Career Henan Chemical Co

Product: Meclizine Dihydrochloride Monohydrate 31884-77-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-99.9%
Supply Ability: 200KG
Release date: 2020-01-07

31884-77-2, Meclizine Dihydrochloride MonohydrateRelated Search:

Dimenhydrinate Betahistine dihydrochloride Meclozine CHLORCYCLIZINE CHLORCYCLIZINE HYDROCHLORIDE Meclizine Dihydrochloride Monohydrate Chlorcyclizine dihydrochloride 1-[(4-CHLOROPHENYL)PHENYLMETHYL]-PIPERAZINE DIHYDROCHLORIDE 1-(4-CHLOROBENZYL)PIPERAZINE (4-CHLOROPHENYL)PHENYLMETHYLAMINE HYDROCHLORIDE Meclizine dihydrochloride 1-(4-Chlorobenzhydryl)piperazine 1-(3-METHYLBENZYL)PIPERAZINE

1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine hydrate dihydrochloride

Meclizine dihydrochloride monohydrate

1-[(4-Chlorophenyl)phenylMethyl]-4-[(3-Methylphenyl)Methyl]piperazine DiHydrochloride Hydrate

Meclizine Related CoMpound B

MECLIZINE HYDROCHLORIDE (500 MG)

Meclizine hydrochloride

Antivert

Permesin

MECLIZINE HYDROCHLORIDE MONOHYDRATE

1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl) methyl]-piperazine dihydrochloride monohydrate

Meclizine Dihydrochloride Monohydrate USP/EP/BP

Meclizine HydrochlorideQ: What is Meclizine Hydrochloride Q: What is the CAS Number of Meclizine Hydrochloride Q: What is the storage condition of Meclizine Hydrochloride Q: What are the applications of Meclizine Hydrochloride

Meclizine Hydrochloride API

Meclizine Hydrochloride (1377009)

(Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride, monohydrate)

Meclozine hydrochloride monohydrate

31884-77-2

C25H31Cl3N2O

C25H27ClN22HClH2O

C25H27ClN22ClHH2O

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