BAY 2416964

ChemicalBook > CAS DataBase List > BAY 2416964

Use In vitro In vivo

Product Name: BAY 2416964
CAS No.: 2242464-44-2
Chemical Name: BAY 2416964
Synonyms: BAY241696;AHR antagonist 3;BAY 2416964 USP/EP/BP;6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(1-methylpyrazol-4-yl)-3-oxopyridazine-4-carboxamide;(S)-6-(4-chlorophenyl)-N-(1-hydroxypropan-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide;4-Pyridazinecarboxamide, 6-(4-chlorophenyl)-2,3-dihydro-N-[(1S)-2-hydroxy-1-methylethyl]-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-
CBNumber: CB15865784
Molecular Formula: C18H18ClN5O3
Formula Weight: 387.82
MOL File: 2242464-44-2.mol

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BAY 2416964 Property

Density: 1.42±0.1 g/cm3(Predicted)
solubility: DMSO:64.0(Max Conc. mg/mL);165.02(Max Conc. mM)
pka: 11.81±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0114330
Product name: BAY2416964
Purity: 99.59%
Packaging: 5mg
Price: $280
Updated: 2021/12/16

ChemScene

Product number: CS-0114330
Product name: BAY2416964
Purity: 99.59%
Packaging: 10mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0114330
Product name: BAY2416964
Purity: 99.59%
Packaging: 25mg
Price: $670
Updated: 2021/12/16

ChemScene

Product number: CS-0114330
Product name: BAY2416964
Purity: 99.59%
Packaging: 50mg
Price: $1050
Updated: 2021/12/16

DC Chemicals

Product number: 020439
Product name: BAY2416964
Packaging: 002
Price: $1200
Updated: 2021/12/16

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BAY 2416964 Chemical Properties,Usage,Production

Use

BAY 2416964 (compound 192) is a potent and orally active antagonist of aryl hydrocarbon receptor (AhR) with IC50 of 341 nM. BAY 2416964 has the potential in the treatment of solid tumors.

In vitro

BAY 2416964 (Example 192) induces AHR-regulated gene CYP1A1 expression with IC50 of 4.30 nM in a human monocytic U937 cells.

In vivo

BAY 2416964 (Example 192) is dissolved in Ethanol/Solutol/Water (10/40/50) and given at 30 mg/kg, QD, p.o.. The efficacy is calculated based on tumor volume. BAY 2416964 (Example 192) is shown to have the potential for solid tumour treatment.

BAY 2416964 Preparation Products And Raw materials

Raw materials

Preparation Products

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2242464-44-2, BAY 2416964Related Search:

BAY1895344 2HCl BAY-2402234 BAY-1125976. BAY-885 BAY-985 BAY 1316957) BAY-1163877 BAY1895344 HCl BAY-1895344 Benzamide, N-[5-(3,5-dicyano-1,4-dihydro-1,2,6-trimethyl-4-pyridinyl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethyl- BAY 2666605 bHLHe76

AHR antagonist 3

(S)-6-(4-chlorophenyl)-N-(1-hydroxypropan-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide

4-Pyridazinecarboxamide, 6-(4-chlorophenyl)-2,3-dihydro-N-[(1S)-2-hydroxy-1-methylethyl]-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-

6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(1-methylpyrazol-4-yl)-3-oxopyridazine-4-carboxamide

BAY 2416964 USP/EP/BP

BAY241696

2242464-44-2