ChemicalBook > CAS DataBase List > 2-METHOXY-5-NITROBENZALDEHYDE

2-METHOXY-5-NITROBENZALDEHYDE

Product Name
2-METHOXY-5-NITROBENZALDEHYDE
CAS No.
25016-02-8
Chemical Name
2-METHOXY-5-NITROBENZALDEHYDE
Synonyms
AKOS B028867;5-Nitro-o-anisaldehyde;5-Nitro-o-anisaldehyde;2-METHOXY-5-NITROBENZALDEHYDE;2-methoxy-5-nitro-benzaldehyd;Benzaldehyde, 2-methoxy-5-nitro-;4-(4-morpholinyl)-6-[[4-(phenylmethyl)-1-piperazinyl]methyl]-1,3,5-triazin-2-amine
CBNumber
CB1676781
Molecular Formula
C8H7NO4
Formula Weight
181.15
MOL File
25016-02-8.mol
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2-METHOXY-5-NITROBENZALDEHYDE Property

Melting point:
89-92 °C (lit.)
Boiling point:
336.7±27.0 °C(Predicted)
Density 
1.322±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
very soluble in Dimethylformamide
form 
powder to crystal
color 
White to Light yellow to Light orange
CAS DataBase Reference
25016-02-8
EPA Substance Registry System
Benzaldehyde, 2-methoxy-5-nitro- (25016-02-8)
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Safety

WGK Germany 
3
HS Code 
2913000090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
515760
Product name
2-Methoxy-5-nitrobenzaldehyde
Purity
97%
Packaging
5g
Price
$296
Updated
2022/05/15
TCI Chemical
Product number
N1034
Product name
5-Nitro-o-anisaldehyde
Purity
min. 98.0 %
Packaging
5G
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
N1034
Product name
5-Nitro-o-anisaldehyde
Purity
min. 98.0 %
Packaging
25G
Price
$108
Updated
2025/07/31
AK Scientific
Product number
J94624
Product name
2-Methoxy-5-nitrobenzaldehyde
Packaging
5g
Price
$119
Updated
2021/12/16
AK Scientific
Product number
1946AB
Product name
2-Methoxy-5-nitrobenzaldehyde
Packaging
5g
Price
$149
Updated
2021/12/16
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2-METHOXY-5-NITROBENZALDEHYDE Chemical Properties,Usage,Production

Synthesis

97-51-8

74-88-4

25016-02-8

General procedure for the synthesis of 2-methoxy-5-nitrobenzaldehyde from 5-nitrosalicylaldehyde and iodomethane: Sodium hydride (NaH, 246 mg) and iodomethane (2.56 g) were added to a solution of 5-nitrosalicylaldehyde (1.00 g, 6.0 mmol) in N,N-dimethylformamide (DMF, 20 ml). The reaction mixture was stirred at 0°C for 8.5 hours. After completion of the reaction, the reaction mixture was extracted with ether and the organic phase was washed sequentially with aqueous sodium bicarbonate, saturated brine and 5% hydrochloric acid/saturated brine. The organic phase was dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give 2-methoxy-5-nitrobenzaldehyde (0.95 g, 87.8% yield) as yellow needle-like crystals. The product was characterized by 1H NMR (CDCl3): δ 10.45 (s, 1H), 8.70 (d, J = 2.9Hz, 1H), 8.45 (dd, J = 8.8, 2.9Hz, 1H), 7.14 (d, J = 8.8Hz, 1H), 4.08 (s, 3H).

References

[1] Angewandte Chemie - International Edition, 2011, vol. 50, # 15, p. 3435 - 3438
[2] Patent: US2013/261295, 2013, A1. Location in patent: Paragraph 0166; 0167
[3] Journal of the American Chemical Society, 2017, vol. 139, # 19, p. 6654 - 6662
[4] Patent: US5837711, 1998, A
[5] Journal of the Chemical Society, 1951, p. 2462,2466

2-METHOXY-5-NITROBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-METHOXY-5-NITROBENZALDEHYDE Suppliers

Chembest Research Laboratories Limited
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TCI (Shanghai) Development Co., Ltd.
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TOKYO CHEMICAL INDUSTRY CO., LTD.
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TCI Europe
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Europe
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Acesys Pharmatech
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18860950986
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China
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View Lastest Price from 2-METHOXY-5-NITROBENZALDEHYDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Methoxy-5-nitrobenzaldehyde 25016-02-8
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-15