Rauwolscine hydrochloride

Product Name: Rauwolscine hydrochloride
CAS No.: 6211-32-1
Chemical Name: Rauwolscine hydrochloride
Synonyms: RAUWOLSCINE;RAUWOLSCINE HCL;Nsc407307;ISOYOHIMBINE;MESOYOHIMBINE;ALPHA-YOHIMBINE;ALPHA-YOHIMBINE HCL;YOHIMBINE HCL, ALPHA-;RAUWOLSCINE HYDROCHLORIDE;α-Yohimbine hydrochloride
CBNumber: CB1684795
Molecular Formula: C21H27ClN2O3
Formula Weight: 390.9
MOL File: 6211-32-1.mol

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Rauwolscine hydrochloride Property

Melting point:: 270-280°C
storage temp.: Store at RT
solubility: H₂O: soluble
form: solid
color: white
Sensitive: Light Sensitive

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Safety

Hazard Codes: T
Risk Statements: 23/24/25
Safety Statements: 22-36/37/39-45
RIDADR: UN 1544 6.1/PG 2
WGK Germany: 3
RTECS: ZG1035000
HazardClass: 6.1
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H330Fatal if inhaled

Precautionary statements

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P320Specific treatment is urgent (see … on this label).

P330Rinse mouth.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J63198
Product name: Rauwolscine hydrochloride, 99%
Packaging: 100mg
Price: $138.65
Updated: 2024/03/01

Cayman Chemical

Product number: 15596
Product name: Rauwolscine (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 15596
Product name: Rauwolscine (hydrochloride)
Purity: ≥98%
Packaging: 100mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 15596
Product name: Rauwolscine (hydrochloride)
Purity: ≥98%
Packaging: 250mg
Price: $151
Updated: 2024/03/01

Tocris

Product number: 0891
Product name: Rauwolscinehydrochloride
Purity: ≥95%(HPLC)
Packaging: 100
Price: $85
Updated: 2021/12/16

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Rauwolscine hydrochloride Chemical Properties,Usage,Production

Description

This alkaloid is isolated as the oxalate from the leaf extract of Rauwolfia canescens L. from which the free base may be obtained as colourless needles which are laevorotatory with [α]³⁰_D - 40° (EtOH). The alkaloid forms crystalline salts: the hydrochloride, m.p. 27S-2S00C (dec.); [α]³⁰_D + 74° (H20); nitrate, m.p. 257-SoC (dec.); oxalate, m.p. 245-6°C and the picrate, m.p. 20SoC. Two active hydrogens are present and the alkaloid furnishes a monoacetyl derivative, m.p. 2l6-SoC (dec.). Treatment with concentrated ammonia solution at room temperature converts the base into rauwolscinic acid, C2oH2403N2.H20, m.p. 262-4°C (dec.); [α]²³_D + l36.So (H20) which yields a crystalline hydrochloride, m.p. 255.5-257.5°C (dec.) and on esterification with MeOH reverts to the original alkaloid. On distillation with Zn dust, rauwolscine yields harman, 2-methylindole (skatole) and isoquinoline.
Chakravarti has shown that the alkaloid is a cardiovascular depressant, shows hypotensive activity and is relatively highly toxic.

Uses

Rauwolscine is a natural alkaloid that acts as a selective and reversible α2-adrenergic receptor antagonist (Ki = 12 nM). It is a stereoisomer of yohimbine, which potently antagonizes both α1- and α2-adrenergic receptors. Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki = 14.3 nM) and as a weak partial agonist at 5-HT1A (IC50 = 1.3 μM).The α2-adrenergic receptor has diverse physiological functions and antagonists like rauwolscine have numerous applications, including the modulation of mood and behavior.

Uses

Standard alpha-2 adrenergic antagonist

Biological Activity

Rauwolscine hydrochloride is a standard α2-adrenergic antagonist (Ki values are 3.5, 4.6, and 0.6 nM at cloned human α2A, α2B, and α2C-adrenoceptors respectively). Partial agonist at 5-HT1A receptors. Also available as part of the α2-Adrenoceptor Tocriset? .

References

Mukherjee., J. Ind. Chern. Soc., 18, 33, 485 (1941)
Mukherjee., ibid, 20, 11 (1943)
Mukherjee., ibid, 23, 6 (1946)
Pharmacology:
Chakravarti., Sci. Cult., (Calcutta), 7, 45S (1942)

Rauwolscine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Rauwolscine hydrochloride manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: RAUWOLSCINE HYDROCHLORIDE 6211-32-1
Price: US $10.50/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-08

Henan Weian Pharmaceutical Co. LTD

Product: Rauwolscine Hydrochloride,Rauwolscine 6211-32-1
Price: US $0.00/Kg/Bag
Min. Order: 100g/Bag
Purity: 99%
Supply Ability: 1-10 tons
Release date: 2021-10-27

Henan Weian Pharmaceutical Co. LTD

Product: Rauwolscine hydrochloride 6211-32-1
Price: US $0.00/Kg/Bag
Min. Order: 100g/Bag
Purity: 99%
Supply Ability: 1-10 tons
Release date: 2021-10-28

6211-32-1, Rauwolscine hydrochlorideRelated Search:

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alpha-yohimbinhydrochloride

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ISOYOHIMBINE

MESOYOHIMBINE

20.alpha.-Yohimban-16.beta.-carboxylic acid, 17.alpha.-hydroxy-, methyl ester, monohydrochloride

Fauwolscine, hydrochloride

Nsc407307

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17α-Hydroxy-20α-yohimban-16β-carboxylicacid,methylesterhydrochloride

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methyl (16beta,17alpha,20alpha)-17-hydroxyyohimban-16-carboxylate hydrochloride

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Rauwolscine Hydrochloride,Rauwolscine

α-Yohimbine hydrochloride

Rauwolscine hydrochloride,α-Yohimbine,Corynanthidine,Rauwolscine,Adrenergic Receptor,Inhibitor,Beta Receptor,inhibit,Isoyohimbine

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6211-32-1

Adrenoceptor