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Synephrine hydrochloride

Product Name
Synephrine hydrochloride
CAS No.
5985-28-4
Chemical Name
Synephrine hydrochloride
Synonyms
SYNEPHRINE HCL;JACS-5985-28-4;UNII-EN5D1IH09S;Synephrine HCl 98%min;N-METHYL OCTOPAMINE HCL;Sympathol hydrochloride;Synephrine hydrochlorid;SYNEPHRINE HYDROCHLORIDE;Synephrine/Synephrine Hcl;(±)-Oxedrine hydrochloride
CBNumber
CB1690109
Molecular Formula
C9H14ClNO2
Formula Weight
203.67
MOL File
5985-28-4.mol
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Synephrine hydrochloride Property

Melting point:
147-150°C
storage temp. 
Refrigerator
solubility 
Methanol (Slightly), Water (Slightly)
form 
Solid
color 
Off-White to Pale Beige
InChI
InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-2-4-8(11)5-3-7;/h2-5,9-12H,6H2,1H3;1H
InChIKey
COTCEGYSNTWJQV-UHFFFAOYSA-N
SMILES
C1(=CC=C(O)C=C1)C(O)CNC.Cl
LogP
-0.030 (est)
CAS DataBase Reference
5985-28-4(CAS DataBase Reference)
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Safety

HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28398
Product name
(±)-Synephrine (hydrochloride)
Packaging
10g
Price
$95
Updated
2024/03/01
Cayman Chemical
Product number
28398
Product name
(±)-Synephrine (hydrochloride)
Packaging
50g
Price
$220
Updated
2024/03/01
Cayman Chemical
Product number
28398
Product name
(±)-Synephrine (hydrochloride)
Packaging
5g
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
28398
Product name
(±)-Synephrine (hydrochloride)
Packaging
25g
Price
$152
Updated
2024/03/01
TRC
Product number
S920001
Product name
rac-SynephrineHydrochloride
Packaging
100g
Price
$410
Updated
2021/12/16
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Synephrine hydrochloride Chemical Properties,Usage,Production

Description

(±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities. It binds to α1A-, α2A-, and α2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 μM, respectively). (±)-Synephrine is an agonist of α1A-ARs in HEK293 cells (EC50 = 4 μM in a reporter assay) but not in CHO cells expressing α2A- or α2C-AR. It also acts as an antagonist of α1A-, α2A-, and α2C-ARs, inhibiting L-phenylephrine-induced activation of α1A-AR in HEK293 cells and activation of α2A- and α2C-ARs induced by the α2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 μM, respectively, in reporter assays). (±)-Synephrine induces contractions in isolated rabbit aortic rings (EC50 = 6.2 μg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day. It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 μg/ml. (±)-Synephrine (50 μM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 μM.

Chemical Properties

Pale Beige Solid

Uses

A α-adrenergic receptor agonist, vasoconstrictor.

Synephrine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Synephrine hydrochloride Suppliers

Canada 1 China 312 China Hong Kong 1 Germany 1 India 2 United Kingdom 5 United States 32 Global 354
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View Lastest Price from Synephrine hydrochloride manufacturers

Hebei Shengyang Water Conservancy Engineering Co., Ltd.
Product
Cjc 5985-28-4
Price
US $18.00-18.00/KG
Min. Order
1KG
Purity
99.9
Supply Ability
5000
Release date
2024-05-07
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Synephrine Hydrochloride 5985-28-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000kg
Release date
2024-05-08
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Synephrine HCl 5985-28-4
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-24

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