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DEHYDROABIETYLAMINE

Product Name
DEHYDROABIETYLAMINE
CAS No.
1446-61-3
Chemical Name
DEHYDROABIETYLAMINE
Synonyms
Leelamine;AMINE D;DEHYDROABIETHYLAMINE;((1R,4aS,10aR)-7-Isopropyl-1,4a-diMethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)MethanaMine;NSC 2955;55.0%(GC);Leelamine HCl;((1R,4aS,10aR);Water galbanum;Dehydrobietylamine
CBNumber
CB1692875
Molecular Formula
C20H31N
Formula Weight
285.47
MOL File
1446-61-3.mol
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DEHYDROABIETYLAMINE Property

Melting point:
44.50℃
Boiling point:
417.89°C (rough estimate)
Density 
0.963±0.06 g/cm3 (20 ºC 760 Torr)
refractive index 
n20/D 1.546(lit.)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform, DMSO, Methanol
form 
White solid.
pka
10.13±0.29(Predicted)
color 
Pale Yellow
optical activity
[α]20/D +56.1°, c = 2.4 in pyridine
BRN 
3084620
CAS DataBase Reference
1446-61-3(CAS DataBase Reference)
EPA Substance Registry System
Dehydroabietylamine (1446-61-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
TP8701000
F 
10-23
HS Code 
29214990
Hazardous Substances Data
1446-61-3(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
105198
Product name
(+)-Dehydroabietylamine
Purity
technical grade, 60%
Packaging
100g
Price
$48.4
Updated
2024/03/01
TCI Chemical
Product number
D1588
Product name
(+)-Dehydroabietylamine [Optical Resolving Agent]
Purity
>90.0%(GC)
Packaging
5g
Price
$94
Updated
2024/03/01
TCI Chemical
Product number
D1180
Product name
Dehydroabietylamine
Purity
min. 55.0 %
Packaging
25G
Price
$36
Updated
2024/03/01
TCI Chemical
Product number
D1588
Product name
(+)-Dehydroabietylamine [Optical Resolving Agent]
Purity
>90.0%(GC)
Packaging
25g
Price
$282
Updated
2024/03/01
Cayman Chemical
Product number
10006148
Product name
Leelamine
Purity
≥98%
Packaging
5mg
Price
$37
Updated
2024/03/01
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DEHYDROABIETYLAMINE Chemical Properties,Usage,Production

Chemical Properties

clear yellow viscous liquid

Uses

Dehydroabiethylamine is a primary amine with high molecular weight; shows a strong antibiotic effect with a broad spectrum of activity against Staphylococcus p.a. (sic), Escherichia coli, Mycobacterium tuberculosis, and Candida albicans.

Definition

ChEBI: [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine is a diterpenoid.

Biological Activity

CB 1 agonist. Displaces binding of [ 3 H]-SR141716A with an IC 50 value of 2.86 μ M.

Purification Methods

The crude base is purified by converting 2g of base in toluene (3.3mL) into the acetate salt by heating at 65-70o with 0.46g of AcOH, and the crystals are collected and dried (0.96g from two crops, m 141-143o). The acetate salt is dissolved in warm H2O, basified with aqueous NaOH and extracted with *C6H6. The dried extract (MgSO4) is evaporated in vacuum leaving a viscous oil which crystallises and can be distilled. [Gottstein & Cheney J Org Chem 30 2072 1965.] The picrate has m 234-236o (from aqueous MeOH), and the formate has m 147-148o (from heptane). [Beilstein 12 IV 3005.]

DEHYDROABIETYLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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DEHYDROABIETYLAMINE Suppliers

Americas 1 Belgium 1 Canada 3 China 168 Europe 4 France 2 Germany 4 India 4 Japan 4 Singapore 1 Slovakia 1 South Korea 1 Switzerland 3 The Netherlands 1 United Kingdom 6 United States 31 Global 235
HBCChem, Inc.
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View Lastest Price from DEHYDROABIETYLAMINE manufacturers

Jiangsu Monade Biological Technology Co., Ltd.
Product
(+)-Dehydroabiethylamine 1446-61-3
Price
US $0.00/ASSAYS
Min. Order
100ASSAYS
Purity
99.99%
Supply Ability
10000
Release date
2021-09-07
Career Henan Chemical Co
Product
DEHYDROABIETYLAMINE 1446-61-3
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
as request
Release date
2018-12-24
Career Henan Chemical Co
Product
DEHYDROABIETYLAMINE 1446-61-3
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10tons
Release date
2018-12-24

1446-61-3, DEHYDROABIETYLAMINERelated Search:

FMOC-ASN(TRT)-OPFP D-DESTHIOBIOTIN 1951424-89-7 DEHYDROABIETYLAMINE (+)-DEHYDROABIETYLAMINE [OPTICAL RESOLVING AGENT],(+)-DEHYDROABIETYLAMINE [OPTICAL RESOLVING AGENT] Polyethylene oxide, dehydroabietylamine polymer DEHYDROABIETYLAMINE Turpentine DEHYDROABIETYL ISOTHIOCYANATE [1R-(1alpha,4abeta,10aalpha)]-4-[[[7-isopropyl-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethylphenanthren-1-yl]methyl](3-oxo-3-phenylpropyl)amino]butan-2-one DEHYDROABIETYLAMINE ACETATE, TECH., 85%,DEHYDROABIETYLAMINE ACETATE,DEHYDROABIETYLAMINE ACETATE, TECH., 85%,DEHYDROABIETYLAMINE ACETATE (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine hydrochloride TOSLAB 13004 TOSLAB 12994 [(1R,4AS,10AR)-7-ISOPROPYL-1,4A-DIMETHYL-1,2,3,4,4A,9,10,10A-OCTAHYDRO-1-PHENANTHRENYL]-N-(4-FLUOROBENZYL)METHANAMINE HYDROCHLORIDE N-{[(1R,4AS,10AR)-7-ISOPROPYL-1,4A-DIMETHYL-1,2,3,4,4A,9,10,10A-OCTAHYDRO-1-PHENANTHRENYL]METHYL}-2-PROPANAMINE HYDROCHLORIDE [(1R,4AS,10AR)-7-ISOPROPYL-1,4A-DIMETHYL-1,2,3,4,4A,9,10,10A-OCTAHYDRO-1-PHENANTHRENYL]-N-(2-METHOXYBENZYL)METHANAMINE HYDROCHLORIDE TOSLAB 13005

  • (+)-DEHYDROABIETYLAMINE
  • DEHYDROABIETYLAMINE
  • (+)-DEHYDROABIETHYLAMINE
  • DEHYDROABIETHYLAMINE
  • D(+)-DEHYDROABIETYLAMINE
  • 1-Phenanthrenemethanamine, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, (1R,4aS,10aR)-
  • 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-, [1R-(1.alpha.,4a.beta.,10a.alpha.)]1-Phenanthrenemethanamine
  • (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-(1-methylethyl-1-phenanthrenemethanamine)
  • NSC 2955
  • 1-phenanthrenemethanamine,1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-met
  • Dehydrobietylamine
  • (1R)-(1,2,3,4,4a,9,10,10aα-Octahydro-7-isopropyl-1,4aβ-dimethylphenanthrene)-1α-methanamine
  • (1R)-1,2,3,4,4a,9,10,10aα-Octahydro-1,4aβ-dimethyl-7-(1-methylethyl)-1α-phenanthrenemethanamine
  • (1R)-1,2,3,4,4a,9,10,10aα-Octahydro-1,4aβ-dimethyl-7-(1-methylethyl)phenanthrene-1α-methanamine
  • (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-isopropyl-1-phenanthrenemethanamine
  • Dehydroabietylamine,60%,tech.
  • Dehydroabietylamine1,4a-Dimethyl-7-isopropyl-1,2,3,4,4a,9,10,10a-octahydro-1- phenanthrenemethylamine
  • (d)-dehyroabiethylamine
  • Leelamine hydrochloride
  • DEHYDROABIETYLAMINE, TECH., 60%
  • DehydroabietylamineTech60%
  • LYLAMINE HYDROCHLORIDE
  • (1R,4AS,10AR)-1,2,3,4,4A,9,10,10A-OCTAHYDRO-1-,4A-DIMETHYL-7-(1-METHYLETHYL)-1-PHENANTHRENEMETHANAMINE HYDROCHLORIDE
  • 1,4A-DIMETHYL-7-ISOPROPYL-1,2,3,4,4A,9,10,10A-OCTAHYDRO-1-PHENANTHRENEMETHYLAMINE
  • 1 4A-DIMETHYL-7-ISOPROPYL-1 2 3,4A 9 10 10A-OCTAHYDRO-1-PHENANTHRENE METHYLAMINE
  • AMINE D
  • (1r-(1alpha,4abeta,10aalpha))-hylethyl)
  • [1theta-(1alpha,4abeta,10aalpha)]-hylethyl)
  • 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-,[1R-(1.alpha.,4a.beta.,10a.alpha.)]1-Phenanthrenemethanamine
  • 13-isopropylpodocarpa-8,11,13-trien-15-amine
  • 13-trien-15-amine,13-isopropyl-podocarpa-11
  • (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine ,60%
  • ((1S,4aS,10aR)-7-isopropyl-1,4a-diMethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)MethanaMine
  • Leelamine
  • (+)DehyroabietylaMine
  • (1R,4aS,10aR)-1-1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-(1-methylethyl)-phenanthrenemethanamine
  • ((1R,4aS,10aR)-7-Isopropyl-1,4a-diMethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)MethanaMine
  • DehydroabiethylaMine (>80%)
  • (+)-Dehydroabietylamine technical grade, 60%
  • Leelamine HCl
  • (+)-Dehydroabietylamine&nbsp
  • [Optical Resolving Agent]
  • ((1R,4aS,10aR)
  • -7-Isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)
  • (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1,4adimethyl- 7-(1-methylethyl)-1-phenanthrenemethanamine,99%d.e.
  • (+)-Dehydroabietylamine[OpticalResolvingAgent]&gt
  • 55.0%(GC)
  • Dehydroabietylamine &gt
  • (+)-Dehydroabietylamine [Optical Resolving Agent]
  • (+)-Dehydroabiethylamine
  • 1446-61-3 C20H31N DEHYDROABIETYLAMINE
  • (+)-Dehydroabietylamine
  • Leelamine free base
  • Pyruvate dehydrogenase kinase,PDH kinase,Dehydroabiethylamine,Inhibitor,PDHK,Cannabinoid Receptor,inhibit
  • Water galbanum
  • 1446-61-3
  • C20H31N
  • C20H31NHCl