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DROXIDOPA

Product Name
DROXIDOPA
CAS No.
23651-95-8
Chemical Name
DROXIDOPA
Synonyms
L-threo-3,4-Dihydroxyphenylserine;Droxidopa (JAN);l-dops;SM 5688;roxidopa;DROXIDOPA;Droxydopa;l-threodops;Droxidopa>Droxidopa-13C6
CBNumber
CB1699324
Molecular Formula
C9H11NO5
Formula Weight
213.19
MOL File
23651-95-8.mol
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DROXIDOPA Property

Melting point:
232-235° (dec); mp 229-232° (dec) (Ohashi)
alpha 
D20 -39° (c = 1 in 1N aq HCl); D20 -42.0° (c = 1 in 1N aq HCl)
Boiling point:
549.8±50.0 °C(Predicted)
Density 
1.608±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: ≥3mg/mL
form 
powder
pka
2.09±0.24(Predicted)
color 
white to tan
Merck 
14,3457
Stability:
Hygroscopic
CAS DataBase Reference
23651-95-8
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
RTECS 
VT9626010
HS Code 
29225090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D9446
Product name
L-DOPS
Purity
≥98% (HPLC)
Packaging
5mg
Price
$147
Updated
2024/03/01
Sigma-Aldrich
Product number
D9446
Product name
L-DOPS
Purity
≥98% (HPLC)
Packaging
25mg
Price
$583
Updated
2024/03/01
TCI Chemical
Product number
D4235
Product name
Droxidopa
Purity
>98.0%(HPLC)(T)
Packaging
50mg
Price
$168
Updated
2024/03/01
TCI Chemical
Product number
D4235
Product name
Droxidopa
Purity
>98.0%(HPLC)(T)
Packaging
200mg
Price
$480
Updated
2024/03/01
Cayman Chemical
Product number
23779
Product name
Droxidopa
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
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DROXIDOPA Chemical Properties,Usage,Production

Description

Droxidopa is a synthetic amino acid precursor of (-)-norepinephrine which is absorbed from the gut and metabolized to norepinephrine. In Parkinsonian patients, droxidopa added to existing levodopa/decarboxylase inhibitor therapy produces significant improvements in retropulsion, dysarthria and muscular rigidity refractory to other treatments; however, tremor was unaffected.

Description

Droxidopa (L-DOPS) is a synthetic precursor and prodrug of the neurotransmitter norepinephrine. It is transformed into norepinephrine through the action of DOPA decarboxylase. L-DOPS increases norepinephrine levels in the rat heart following intraperitoneal administration and in the brain following intracerebroventricular administration at doses of 125 and 100 μg/animal, respectively. It increases arterial pressure and mesenteric arterial resistance in rats with ligated portal vein or biliary ducts when used at doses of 25-50 mg/kg. L-DOPS crosses the blood brain barrier, however, its effects can be blocked by the peripherally-restricted DOPA decarboxylase inhibitor carbidopa , indicating that the mechanism is peripheral. Formulations containing droxidopa are used in the treatment of neurogenic orthostatic hypotension.

Chemical Properties

Off-White Solid

Originator

Sumitomo (Japan)

Uses

The L-threo-form Droxidopa. A synthetic amino acid precursor of Norepinephrine (N674500). Antiparkinsonian.

Uses

Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).

Uses

L-DOPS has been administered for clinical trial studies in mice with amyloid pathology.

Definition

ChEBI: A serine derivative that is L-serine substituted at the beta-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension

brand name

DOPS

General Description

L-DOPS, also called L-threo 3,4-Dihydroxyphenylserine or droxidopa is a catecholamine. L-DOPS has many clinical advantages and may be useful for treating norepinephrine deficiency. It is used for treating neurogenic orthostatic hypotension and improves norepinephrine levels. L-DOPS mediates reduction of amyloid plaques and could have a therapeutic potential for treating amyloid pathology.

Biochem/physiol Actions

L-DOPS is a norepinephrine precursor in vivo.

DROXIDOPA Preparation Products And Raw materials

Raw materials

Preparation Products

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DROXIDOPA Suppliers

Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4496
Advantage
50
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View Lastest Price from DROXIDOPA manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
DROXIDOPA 23651-95-8
Price
US $19.00/KG
Min. Order
1KG
Purity
99.%
Supply Ability
50 ton
Release date
2024-08-20
Henan Fengda Chemical Co., Ltd
Product
DROXIDOPA 23651-95-8
Price
US $8.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-23
Shaanxi Dideu Medichem Co. Ltd
Product
Droxidopa 23651-95-8
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-09

23651-95-8, DROXIDOPARelated Search:


  • Droxidopa (JAN)
  • L-threo-3,4-Dihydroxyphenylserine
  • L-threo-b-(3,4-Dihydroxyphenyl)serine
  • L-Tyrosine, b,3-dihydroxy-, threo-
  • L-Tyrosine, β,3-dihydroxy-, (βR)-
  • Serine, 3-(3,4-dihydroxyphenyl)-, L-threo- (8CI)
  • SM 5688
  • threo-Dopaserine
  • (2S,3R)-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropionic acid
  • (βR)-β,3-Dihydroxy-L-tyrosine
  • (-)-(2S,3R)-2-Amino-3-hydroxy-3-(3,4-dihydroxyphenyl)propionic acid
  • L-threo-Droxidopa
  • DROXIDOPA
  • Droxydopa
  • Droxidopa-13C6
  • (2S,3R)-2-aMino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid
  • DROXIDOPA,SM 5688
  • L-Tyrosine, b,3-dihydroxy-, (bR)-
  • (2S,3R)-3-(3,4-Dihydroxyphenyl)-2-amino-3-hydroxypropanoic acid
  • Droxidopa impurity B
  • Droxidopa (L DOPS
  • SM5688; DROXIDOPA (L DOPS;SM 5688)
  • Droxidopa (L-DOPS,SM-5688)
  • (-)-(2s,3r)-2-amino-3-hydroxy-3-(3,4-dihydroxyphenyl)propionicacid
  • 3-dihydroxy-bet(beta-r)-l-tyrosin
  • 3-dihydroxy-betthreo-l-tyrosin
  • 4-dihydroxyphenyl)-3-(l-threo-serin
  • l-dops
  • l-threo-3-(3,4-dihydroxyphenyl)serine
  • l-threodops
  • Droxidopa impurity A
  • Droxidopa&gt
  • DROXIDOPA USP/EP/BP
  • L-3,4-Dihydroxyphenylserine trifluoroacetate salt
  • L-3,4-Dihydroxyphenylserine
  • (2S,3R)-2-azaniumyl-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate
  • DroxidopaQ: What is Droxidopa Q: What is the CAS Number of Droxidopa Q: What is the storage condition of Droxidopa Q: What are the applications of Droxidopa
  • roxidopa
  • Droxidopa Reference Standard
  • 23651-95-8
  • C9H11NO5
  • Amines
  • Aromatics
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Inhibitors