DROXIDOPA
- Product Name
- DROXIDOPA
- CAS No.
- 23651-95-8
- Chemical Name
- DROXIDOPA
- Synonyms
- L-threo-3,4-Dihydroxyphenylserine;Droxidopa (JAN);l-dops;SM 5688;roxidopa;DROXIDOPA;Droxydopa;l-threodops;Droxidopa>Droxidopa-13C6
- CBNumber
- CB1699324
- Molecular Formula
- C9H11NO5
- Formula Weight
- 213.19
- MOL File
- 23651-95-8.mol
DROXIDOPA Property
- Melting point:
- 232-235° (dec); mp 229-232° (dec) (Ohashi)
- alpha
- D20 -39° (c = 1 in 1N aq HCl); D20 -42.0° (c = 1 in 1N aq HCl)
- Boiling point:
- 549.8±50.0 °C(Predicted)
- Density
- 1.608±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: ≥3mg/mL
- form
- powder
- pka
- 2.09±0.24(Predicted)
- color
- white to tan
- Merck
- 14,3457
- Stability:
- Hygroscopic
- InChI
- InChI=1/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/s3
- InChIKey
- QXWYKJLNLSIPIN-WWXSATIUNA-N
- SMILES
- [C@H](C1C=CC(O)=C(O)C=1)(O)[C@H](N)C(=O)O |&1:0,10,r|
- CAS DataBase Reference
- 23651-95-8
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D9446
- Product name
- L-DOPS
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $151
- Updated
- 2025/07/31
- Product number
- D9446
- Product name
- L-DOPS
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $599
- Updated
- 2025/07/31
- Product number
- D4235
- Product name
- Droxidopa
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 50mg
- Price
- $160
- Updated
- 2025/07/31
- Product number
- D4235
- Product name
- Droxidopa
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 200mg
- Price
- $456
- Updated
- 2025/07/31
- Product number
- 23779
- Product name
- Droxidopa
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
DROXIDOPA Chemical Properties,Usage,Production
Description
Droxidopa is a synthetic amino acid precursor of (-)-norepinephrine which is absorbed from the gut and metabolized to norepinephrine. In Parkinsonian patients, droxidopa added to existing levodopa/decarboxylase inhibitor therapy produces significant improvements in retropulsion, dysarthria and muscular rigidity refractory to other treatments; however, tremor was unaffected.
Description
Droxidopa (L-DOPS) is a synthetic precursor and prodrug of the neurotransmitter norepinephrine. It is transformed into norepinephrine through the action of DOPA decarboxylase. L-DOPS increases norepinephrine levels in the rat heart following intraperitoneal administration and in the brain following intracerebroventricular administration at doses of 125 and 100 μg/animal, respectively. It increases arterial pressure and mesenteric arterial resistance in rats with ligated portal vein or biliary ducts when used at doses of 25-50 mg/kg. L-DOPS crosses the blood brain barrier, however, its effects can be blocked by the peripherally-restricted DOPA decarboxylase inhibitor carbidopa , indicating that the mechanism is peripheral. Formulations containing droxidopa are used in the treatment of neurogenic orthostatic hypotension.
Chemical Properties
Off-White Solid
Originator
Sumitomo (Japan)
Uses
The L-threo-form Droxidopa. A synthetic amino acid precursor of Norepinephrine (N674500). Antiparkinsonian.
Uses
Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).
Uses
L-DOPS has been administered for clinical trial studies in mice with amyloid pathology.
Definition
ChEBI: A serine derivative that is L-serine substituted at the beta-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension
brand name
DOPS
General Description
L-DOPS, also called L-threo 3,4-Dihydroxyphenylserine or droxidopa is a catecholamine. L-DOPS has many clinical advantages and may be useful for treating norepinephrine deficiency. It is used for treating neurogenic orthostatic hypotension and improves norepinephrine levels. L-DOPS mediates reduction of amyloid plaques and could have a therapeutic potential for treating amyloid pathology.
Biochem/physiol Actions
L-DOPS is a norepinephrine precursor in vivo.
References
[1] J BARTHOLINI. The stereoisomers of 3,4-dihydroxyphenylserine as precursors of norepinephrine.[J]. Journal of Pharmacology and Experimental Therapeutics, 1975, 193 2: 523-532.
[2] MAR COLL. Droxidopa, an oral norepinephrine precursor, improves hemodynamic and renal alterations of portal hypertensive rats??[J]. Hepatology, 2012, 56 5: 1849-1860. DOI: 10.1002/hep.25845
[3] HORACIO KAUFMANN Jose A P Lucy Norcliffe Kaufmann. Droxidopa in neurogenic orthostatic hypotension.[J]. Expert Review of Cardiovascular Therapy, 2015, 13 8: 875-891. DOI: 10.1586/14779072.2015.1057504
DROXIDOPA Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DROXIDOPA manufacturers
- Product
- DROXIDOPA 23651-95-8
- Price
- US $1.00-4.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2025-09-11
- Product
- DROXIDOPA 23651-95-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-31
- Product
- DROXIDOPA 23651-95-8
- Price
- US $19.00/KG
- Min. Order
- 1KG
- Purity
- 99.%
- Supply Ability
- 50 ton
- Release date
- 2024-08-20