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1H-1,2,4-Triazole-1-carboximidamide hydrochloride

Product Name
1H-1,2,4-Triazole-1-carboximidamide hydrochloride
CAS No.
19503-26-5
Chemical Name
1H-1,2,4-Triazole-1-carboximidamide hydrochloride
Synonyms
1H-1,2,4-triazole-1-carboxiMidaMide hydrochloride;NOLA-010;1H-1,2,4-TRI;TIMTEC-BB SBB004089;Methotrexate (Abitrexate);1-CARBAMIDINO-1,2,4-TRIAZOLE;1,2,4-triazole-1-carboximidamide;1H-1,2,4-Triazole-1-CarboxaMidine;1-AMIDINO-1,2,4-TRIAZOLE HYDROCHLORIDE;1H-1,2,4-triazole-1-carboximidamide HCl
CBNumber
CB1711419
Molecular Formula
C3H6ClN5
Formula Weight
147.57
MOL File
19503-26-5.mol
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1H-1,2,4-Triazole-1-carboximidamide hydrochloride Property

Melting point:
215-220 °C
storage temp. 
Inert atmosphere,Room Temperature
Water Solubility 
Soluble in water
form 
powder to crystal
color 
White to Almost white
BRN 
9500271
InChI
InChI=1S/C3H5N5.ClH/c4-3(5)8-2-6-1-7-8;/h1-2H,(H3,4,5);1H
InChIKey
JDDXNENZFOOLTP-UHFFFAOYSA-N
SMILES
C(N1N=CN=C1)(N)=N.Cl
CAS DataBase Reference
19503-26-5
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36-52/53-43
Safety Statements 
26-36/37-61
RIDADR 
2811
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
III
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
T3124
Product name
1,2,4-Triazole-1-carboximidamide Hydrochloride
Purity
>98.0%(T)
Packaging
1g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
T3124
Product name
1,2,4-Triazole-1-carboximidamide Hydrochloride
Purity
>98.0%(T)
Packaging
5g
Price
$42
Updated
2024/03/01
Alfa Aesar
Product number
H60475
Product name
1H-1,2,4-Triazole-1-carboxamidine hydrochloride, 98%
Packaging
5g
Price
$18.65
Updated
2024/03/01
Alfa Aesar
Product number
H60475
Product name
1H-1,2,4-Triazole-1-carboxamidine hydrochloride, 98%
Packaging
25g
Price
$79.2
Updated
2024/03/01
TRC
Product number
T767418
Product name
1H-1,2,4-Triazole-1-carboximidamideHydrochloride
Packaging
100mg
Price
$75
Updated
2021/12/16
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1H-1,2,4-Triazole-1-carboximidamide hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White crystalline

Uses

[1,2,4]Triazole-1-carboxamidine is an intermediate used in the synthesis of peramivir (P285500), a neuraminidase inhibitor developed as an antiviral agent for the treatment of influenza.

Synthesis

1H-1,2,4-Triazole-1-carboxamidine hydrochloride is prepared by the reaction of dicyandiamide and 1,2,4-Triazole. The steps are as follows:
Dissolve the compound (19.7 g, 0.29 mol) in 20 ml of tetrahydrofuran, and the temperature was raised to 70℃. A solution of dicyandiamide (20 g, 0.24 mol) was added and a solution of 4 mol / L HCl in tetrahydrofuran 27 g, 0.26 mol) at 70℃ for 2 h, the temperature was removed and cooled to room temperature. The solid was removed by filtration and 26.0 g was removed by filtration. The solvent was dried in vacuo at 45℃ to give a colorless oil which was recrystallized from methanol: dichloromethane = 2: 1 Of the mixed solution 50ml recrystallization, cooling crystallization, suction filter to get 6.2g solid, drying a total of 30.1g white powder. Yield 90.3%, purity 99,8%.

1H-1,2,4-Triazole-1-carboximidamide hydrochloride Preparation Products And Raw materials

Raw materials

1,2,4-Triazole Ethanol Sodium chloride 1,4-Dioxane Hydrochloric acid Cyanamide Sulfuric acid

Preparation Products

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1H-1,2,4-Triazole-1-carboximidamide hydrochloride Suppliers

China 192 Germany 3 India 6 Japan 1 Switzerland 1 United States 12 Global 215
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View Lastest Price from 1H-1,2,4-Triazole-1-carboximidamide hydrochloride manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
1H-1,2,4-TRIAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE 19503-26-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Zhuozhou Wenxi import and Export Co., Ltd
Product
1H-1,2,4-TRIAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE 19503-26-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
1H-1,2,4-TRIAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE 19503-26-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

19503-26-5, 1H-1,2,4-Triazole-1-carboximidamide hydrochlorideRelated Search:

SCH 58261 FLUQUINCONAZOLE MRS 1220 CGS 15943 ZM 241385 1H-1,2,4-Triazole-1-carboximidamide hydrochloride batelapine Bemitradine SALOR-INT L121010-1EA SALOR-INT L120995-1EA SALOR-INT L120987-1EA 3-(4-CHLOROPHENYL)-1-(8-IMINO-8,9-DIHYDRO-7H-[1,2,4]TRIAZOLO[1,5-D][1,2,4]TRIAZEPIN-5-YL)-5-(TRIFLUOROMETHYL)-4,5-DIHYDRO-1H-PYRAZOL-5-OL SALOR-INT L121002-1EA 1-(7-AMINO[1,2,4]TRIAZOLO[1,5-C]PYRIMIDIN-5-YL)-3-(4-CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-4,5-DIHYDRO-1H-PYRAZOL-5-OL 1-(8-IMINO-8,9-DIHYDRO-7H-[1,2,4]TRIAZOLO[1,5-D][1,2,4]TRIAZEPIN-5-YL)-3-(2-METHOXYPHENYL)-5-(TRIFLUOROMETHYL)-4,5-DIHYDRO-1H-PYRAZOL-5-OL ZM 241385, [2-3H] 3,5-DIAMINO-1H-1,2,4-TRIAZOLE-1-CARBOXIMIDAMIDE HYDROCHLORIDE 4-FLUOROBENZALDEHYDE (8-IMINO-8,9-DIHYDRO-7H-[1,2,4]TRIAZOLO[1,5-D][1,2,4]TRIAZEPIN-5-YL)HYDRAZONE

  • 1H-1,2,4-TRIAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE
  • 1-CARBAMIDINO-1,2,4-TRIAZOLE
  • 1H-1,2,4-Triazole-1-carboxamidine monohydrochloride ,98.5%
  • 1-AMIDINO-1,2,4-TRIAZOLE HYDROCHLORIDE
  • TIMTEC-BB SBB004089
  • 1h-1,2,4-triazole-1-carboxamidinehydrochloride
  • 1H-1,2,4-TRIAZOLE-1-CARBOXAMIDINE MONOHY
  • (1H)-1,2,4-Triazole-1-carboxamidineHClpurum
  • (1H)-1,2,4-Triazole-1-carboxamidinemonohydrochloridepurum
  • 1-amidino-1h-1,2,4-triazole hydrochloride
  • 1H-1,2,4-TRIAZOLE-1-CARBOXAMIDINE MONOHY DROCHLORIDE PURUM 98+%
  • 1H-1,2,4-triazole-1-carboxiMidaMide hydrochloride
  • 1H-1,2,4-Triazole-1-CarboxaMidine
  • Methotrexate (Abitrexate)
  • 1H-1,2,4-Triazole-1-carboxaMidine Monohydrochloride ,98%
  • [1,2,4]Triazole-1-carboxaMidine Hydrochloride
  • 1,2,4-Triazole-1-carboximidamide Hydrochloride
  • 1-Carbamimidoyl-1,2,4-triazole Hydrochloride
  • 1H-1,2,4-Triazole-1-carboximidamide, hydrochloride (1:1)
  • 1H-1,2,4-Triazole-1-carboxamidine hydrochloride≥ 98%(Titration)
  • 1-Amidino-1,2,4-triazole monohydrochloride
  • NOLA-010
  • 1H-1,2,4-TRI
  • TIANFU-CHEM - 1H-1,2,4-TRIAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE
  • 1,2,4-triazole-1-carboximidamide
  • 1H-1,2, 4-triazol-1-methylamidine monohydrochloride
  • 1H-1,2,4-triazole-1-carboximidamide HCl
  • 19503-26-5
  • C3H6ClN5
  • C3H5N5HCl
  • C3H5N5ClH
  • Guanidine Protection/Guanidinylation
  • Peptide Synthesis
  • Specialty Synthesis