1H-1,2,4-Triazole-1-carboximidamide hydrochloride
- Product Name
- 1H-1,2,4-Triazole-1-carboximidamide hydrochloride
- CAS No.
- 19503-26-5
- Chemical Name
- 1H-1,2,4-Triazole-1-carboximidamide hydrochloride
- Synonyms
- 1H-1,2,4-triazole-1-carboxiMidaMide hydrochloride;NOLA-010;1H-1,2,4-TRI;TIMTEC-BB SBB004089;Methotrexate (Abitrexate);1-CARBAMIDINO-1,2,4-TRIAZOLE;1,2,4-triazole-1-carboximidamide;1H-1,2,4-Triazole-1-CarboxaMidine;1-AMIDINO-1,2,4-TRIAZOLE HYDROCHLORIDE;1H-1,2,4-triazole-1-carboximidamide HCl
- CBNumber
- CB1711419
- Molecular Formula
- C3H6ClN5
- Formula Weight
- 147.57
- MOL File
- 19503-26-5.mol
1H-1,2,4-Triazole-1-carboximidamide hydrochloride Property
- Melting point:
- 215-220 °C
- storage temp.
- Inert atmosphere,Room Temperature
- Water Solubility
- Soluble in water
- form
- powder to crystal
- color
- White to Almost white
- BRN
- 9500271
- InChI
- InChI=1S/C3H5N5.ClH/c4-3(5)8-2-6-1-7-8;/h1-2H,(H3,4,5);1H
- InChIKey
- JDDXNENZFOOLTP-UHFFFAOYSA-N
- SMILES
- C(N1N=CN=C1)(N)=N.Cl
- CAS DataBase Reference
- 19503-26-5
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36-52/53-43
- Safety Statements
- 26-36/37-61
- RIDADR
- 2811
- WGK Germany
- 3
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- T3124
- Product name
- 1,2,4-Triazole-1-carboximidamide Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $16
- Updated
- 2024/03/01
- Product number
- T3124
- Product name
- 1,2,4-Triazole-1-carboximidamide Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $42
- Updated
- 2024/03/01
- Product number
- H60475
- Product name
- 1H-1,2,4-Triazole-1-carboxamidine hydrochloride, 98%
- Packaging
- 5g
- Price
- $18.65
- Updated
- 2024/03/01
- Product number
- H60475
- Product name
- 1H-1,2,4-Triazole-1-carboxamidine hydrochloride, 98%
- Packaging
- 25g
- Price
- $79.2
- Updated
- 2024/03/01
- Product number
- T767418
- Product name
- 1H-1,2,4-Triazole-1-carboximidamideHydrochloride
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
1H-1,2,4-Triazole-1-carboximidamide hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White crystalline
Uses
[1,2,4]Triazole-1-carboxamidine is an intermediate used in the synthesis of peramivir (P285500), a neuraminidase inhibitor developed as an antiviral agent for the treatment of influenza.
Synthesis
1H-1,2,4-Triazole-1-carboxamidine hydrochloride is prepared by the reaction of dicyandiamide and 1,2,4-Triazole. The steps are as follows:
Dissolve the compound (19.7 g, 0.29 mol) in 20 ml of tetrahydrofuran, and the temperature was raised to 70℃. A solution of dicyandiamide (20 g, 0.24 mol) was added and a solution of 4 mol / L HCl in tetrahydrofuran 27 g, 0.26 mol) at 70℃ for 2 h, the temperature was removed and cooled to room temperature. The solid was removed by filtration and 26.0 g was removed by filtration. The solvent was dried in vacuo at 45℃ to give a colorless oil which was recrystallized from methanol: dichloromethane = 2: 1 Of the mixed solution 50ml recrystallization, cooling crystallization, suction filter to get 6.2g solid, drying a total of 30.1g white powder. Yield 90.3%, purity 99,8%.
1H-1,2,4-Triazole-1-carboximidamide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
1H-1,2,4-Triazole-1-carboximidamide hydrochloride Suppliers
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- Country
- Switzerland
- ProdList
- 6896
- Advantage
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View Lastest Price from 1H-1,2,4-Triazole-1-carboximidamide hydrochloride manufacturers
- Product
- 1H-1,2,4-Triazole-1-carboximidamide hydrochloride 19503-26-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%MIN
- Supply Ability
- 20TON
- Release date
- 2024-08-09
- Product
- 1H-1,2,4-Triazole-1-carboximidamide hydrochloride 19503-26-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 20ton
- Release date
- 2024-08-09
- Product
- 1H-1,2,4-TRIAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE 19503-26-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30