ChemicalBook > CAS DataBase List > Methoxyacetyl chloride

Methoxyacetyl chloride

Product Name: Methoxyacetyl chloride
CAS No.: 38870-89-2
Chemical Name: Methoxyacetyl chloride
Synonyms: Acetyl chloride, methoxy-;METHOXYACETYLCHLORID;METHOXYACETYL CHLORIDE;MEYHOXY ACETYL CHLORIDE;Acetyl chloride,2-Methoxy-;[ChloroMethylating Reagent];Methoxyacetyl Chloride METHOXYACETIC ACID CHLORIDE;METHOXYACETYL CHLORIDE, STAB.;Methoxyacetyl chloride, GC 95%
CBNumber: CB1714283
Molecular Formula: C3H5ClO2
Formula Weight: 108.52
MOL File: 38870-89-2.mol

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Methoxyacetyl chloride Property

Melting point:: <-40°C
Boiling point:: 112-113 °C (lit.)
Density: 1.187 g/mL at 25 °C (lit.)
refractive index: n20/D 1.419(lit.)
Flash point:: 84 °F
storage temp.: 2-8°C
solubility: Miscible with acetone, ether, carbon tetrachloride and chloroform.
form: Liquid
color: Clear colorless to yellow
Water Solubility: reacts
Sensitive: Moisture Sensitive
BRN: 1740244
Stability:: Moisture sensitive
InChIKey: JJKWHOSQTYYFAE-UHFFFAOYSA-N
CAS DataBase Reference: 38870-89-2(CAS DataBase Reference)
NIST Chemistry Reference: Methoxyacetyl chloride(38870-89-2)
EPA Substance Registry System: Acetyl chloride, methoxy- (38870-89-2)

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Safety

Hazard Codes: C
Risk Statements: 10-34-36/37
Safety Statements: 26-36/37/39-45-25-16
RIDADR: UN 2920 8/PG 2
WGK Germany: 3
F: 9-19-21
HazardClass: 8
PackingGroup: II
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M9653
Product name: Methoxyacetyl chloride
Purity: 97%
Packaging: 1g
Price: $48.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: M9653
Product name: Methoxyacetyl chloride
Purity: 97%
Packaging: 10g
Price: $84.3
Updated: 2025/07/31

TRC

Product number: M261128
Product name: Methoxyacetyl chloride
Packaging: 1g
Price: $55
Updated: 2021/12/16

TRC

Product number: M261128
Product name: Methoxyacetyl chloride
Packaging: 5g
Price: $70
Updated: 2021/12/16

Usbiological

Product number: 454538
Product name: Methoxyacetyl chloride
Packaging: 500mg
Price: $305
Updated: 2021/12/16

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Methoxyacetyl chloride Chemical Properties,Usage,Production

Description

Methoxyacetyl chloride is a acylating reagent; precursor to methoxyketene; in combination with Lewis acids is a reagent for aromatic chloromethylation.

Chemical Properties

clear colorless to yellow liquid

Uses

Methoxyacetyl chloride is used as an intermediate for active pharmaceutical ingredients and dyes. Further, it acts as a precursor for the synthesis of agrochemicals.

Synthesis

625-45-6

38870-89-2

Step 1: To a solution of methoxyacetic acid (20 mL, 0.26 mol) in dichloromethane (170 mL) was added dropwise oxalyl chloride (30 mL, 0.34 mol) and a catalytic amount of DMF (a few drops) at 0 °C. The reaction mixture was stirred at room temperature overnight and the solvent was subsequently removed by rotary evaporator. The residue was distilled under reduced pressure to afford methoxyacetyl chloride (54b, 25.4 g, 90% yield).

References

[1] Patent: WO2008/33562, 2008, A2. Location in patent: Page/Page column 74
[2] Patent: US2009/76005, 2009, A1. Location in patent: Page/Page column 36
[3] Journal of Organic Chemistry, 2003, vol. 68, # 17, p. 6832 - 6835
[4] European Journal of Organic Chemistry, 2005, # 12, p. 2459 - 2467
[5] Tetrahedron, 2018, vol. 74, # 27, p. 3663 - 3670

Methoxyacetyl chloride Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide Chloroacetic acid Methoxyacetic acid Thionyl chloride

Preparation Products

Metalaxyl ISOCYANATO(METHOXY)METHANE Oxadixyl

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View Lastest Price from Methoxyacetyl chloride manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Methoxyacetyl chloride 38870-89-2
Price: US $1.00-4.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2025-05-19

Hebei Chuanghai Biotechnology Co., Ltd

Product: Methoxyacetyl chloride 38870-89-2
Price: US $8.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-28

Career Henan Chemical Co

Product: Methoxyacetyl chloride 38870-89-2
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: as request
Release date: 2018-12-24

38870-89-2, Methoxyacetyl chlorideRelated Search:

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METHOXYACETYL CHLORIDE, STAB.

Methoxyacetyl chloride, stabilized, ca. 95%

MEYHOXY ACETYL CHLORIDE

Methoxyacetyl chloride, GC 95%

Methoxyacetyl chloride, 97%, stab. with ca 0.3% magnesium oxide

Methoxyacetyl Chloride [Chloromethylating Reagent]

Methoxyacetyl chloride, ca. 95%, stabilized

Methoxyacetyl chloride, stabilized

Methoxyacetyl chloride, 97%, stabilized

Methoxyacetyl chloride, stabilized, ca. 95% 50GR

[ChloroMethylating Reagent]

Methoxyacetyl Chloride&nbsp

Acetyl chloride,2-Methoxy-

Methoxyacetyl Chloride [ChloroMethylating Reagent], 95.0%(GC&T

METHOXYACETIC ACID CHLORIDE

METHOXYACETYLCHLORID

METHOXYACETYL CHLORIDE

Methoxyacetyl chloride stab. with 0.3 % MgO, GC 97%

Methoxyacetyl chloride, stabilized with &ap:0.3% magnesium oxide

Acetyl chloride, methoxy-

MethoxyacetylChloride[ChloromethylatingReagent]&gt

Methoxyacetyl chloride stab. with 0.3 % MgO

38870-89-2

CH3OCH2COCl

Halogenation

Chlorination

Carbonyl Compounds

Building Blocks

Acid Halides

Organic Building Blocks

Chlorination

Halogenation

Synthetic Organic Chemistry