Methoxyacetyl chloride
- Product Name
- Methoxyacetyl chloride
- CAS No.
- 38870-89-2
- Chemical Name
- Methoxyacetyl chloride
- Synonyms
- Acetyl chloride, methoxy-;METHOXYACETYLCHLORID;METHOXYACETYL CHLORIDE;MEYHOXY ACETYL CHLORIDE;Acetyl chloride,2-Methoxy-;[ChloroMethylating Reagent];Methoxyacetyl Chloride METHOXYACETIC ACID CHLORIDE;METHOXYACETYL CHLORIDE, STAB.;Methoxyacetyl chloride, GC 95%
- CBNumber
- CB1714283
- Molecular Formula
- C3H5ClO2
- Formula Weight
- 108.52
- MOL File
- 38870-89-2.mol
Methoxyacetyl chloride Property
- Melting point:
- <-40°C
- Boiling point:
- 112-113 °C (lit.)
- Density
- 1.187 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.419(lit.)
- Flash point:
- 84 °F
- storage temp.
- 2-8°C
- solubility
- Miscible with acetone, ether, carbon tetrachloride and chloroform.
- form
- Liquid
- color
- Clear colorless to yellow
- Water Solubility
- reacts
- Sensitive
- Moisture Sensitive
- BRN
- 1740244
- Stability:
- Moisture sensitive
- InChIKey
- JJKWHOSQTYYFAE-UHFFFAOYSA-N
- CAS DataBase Reference
- 38870-89-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Methoxyacetyl chloride(38870-89-2)
- EPA Substance Registry System
- Acetyl chloride, methoxy- (38870-89-2)
Safety
- Hazard Codes
- C
- Risk Statements
- 10-34-36/37
- Safety Statements
- 26-36/37/39-45-25-16
- RIDADR
- UN 2920 8/PG 2
- WGK Germany
- 3
- F
- 9-19-21
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29189900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H314Causes severe skin burns and eye damage
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M9653
- Product name
- Methoxyacetyl chloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $48.2
- Updated
- 2025/07/31
- Product number
- M9653
- Product name
- Methoxyacetyl chloride
- Purity
- 97%
- Packaging
- 10g
- Price
- $84.3
- Updated
- 2025/07/31
- Product number
- M261128
- Product name
- Methoxyacetyl chloride
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- M261128
- Product name
- Methoxyacetyl chloride
- Packaging
- 5g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 454538
- Product name
- Methoxyacetyl chloride
- Packaging
- 500mg
- Price
- $305
- Updated
- 2021/12/16
Methoxyacetyl chloride Chemical Properties,Usage,Production
Description
Methoxyacetyl chloride is a acylating reagent; precursor to methoxyketene; in combination with Lewis acids is a reagent for aromatic chloromethylation.
Chemical Properties
clear colorless to yellow liquid
Uses
Methoxyacetyl chloride is used as an intermediate for active pharmaceutical ingredients and dyes. Further, it acts as a precursor for the synthesis of agrochemicals.
Synthesis
625-45-6
38870-89-2
Step 1: To a solution of methoxyacetic acid (20 mL, 0.26 mol) in dichloromethane (170 mL) was added dropwise oxalyl chloride (30 mL, 0.34 mol) and a catalytic amount of DMF (a few drops) at 0 °C. The reaction mixture was stirred at room temperature overnight and the solvent was subsequently removed by rotary evaporator. The residue was distilled under reduced pressure to afford methoxyacetyl chloride (54b, 25.4 g, 90% yield).
References
[1] Patent: WO2008/33562, 2008, A2. Location in patent: Page/Page column 74
[2] Patent: US2009/76005, 2009, A1. Location in patent: Page/Page column 36
[3] Journal of Organic Chemistry, 2003, vol. 68, # 17, p. 6832 - 6835
[4] European Journal of Organic Chemistry, 2005, # 12, p. 2459 - 2467
[5] Tetrahedron, 2018, vol. 74, # 27, p. 3663 - 3670
Methoxyacetyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
Methoxyacetyl chloride Suppliers
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View Lastest Price from Methoxyacetyl chloride manufacturers
- Product
- Methoxyacetyl chloride 38870-89-2
- Price
- US $1.00-4.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2025-05-19
- Product
- Methoxyacetyl chloride 38870-89-2
- Price
- US $8.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-28
- Product
- Methoxyacetyl chloride 38870-89-2
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- as request
- Release date
- 2018-12-24