ChemicalBook > CAS DataBase List > Ethyl 2-amino-1,3-benzothiazole-6-carboxylate

Ethyl 2-amino-1,3-benzothiazole-6-carboxylate

Product Name
Ethyl 2-amino-1,3-benzothiazole-6-carboxylate
CAS No.
50850-93-6
Chemical Name
Ethyl 2-amino-1,3-benzothiazole-6-carboxylate
Synonyms
Ethyl 2-aminobenzo[d]thiazole-6-carboxylate;Ethyl 2-amino-1;AKOS BBS-00000329;IFLAB-BB F1981-0015;TIMTEC-BB SBB010144;3-benzothiazole-6-carboxylate;2-AMINO-6-ETHOXYCARBONYLBENZOTHIAZOLE;ETHYL 2-AMINO-BENZOTHIAZOLE-6-CARBOXYLATE;Ethyl2-Aminobenzothiazole-6-carboxylate>Ethyl2-aminobenzothiazole-6-carboxylate,97%
CBNumber
CB1722222
Molecular Formula
C10H10N2O2S
Formula Weight
222.26
MOL File
50850-93-6.mol
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Ethyl 2-amino-1,3-benzothiazole-6-carboxylate Property

Melting point:
241-243°C
Boiling point:
386.8±34.0 °C(Predicted)
Density 
1.364±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
2.79±0.10(Predicted)
form 
Solid
color 
White to Orange to Green
InChI
InChI=1S/C10H10N2O2S/c1-2-14-9(13)6-3-4-7-8(5-6)15-10(11)12-7/h3-5H,2H2,1H3,(H2,11,12)
InChIKey
VYJSGJXWKSDUSG-UHFFFAOYSA-N
SMILES
S1C2=CC(C(OCC)=O)=CC=C2N=C1N
CAS DataBase Reference
50850-93-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
2934208090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
E0985
Product name
Ethyl 2-Aminobenzothiazole-6-carboxylate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$27
Updated
2025/07/31
TCI Chemical
Product number
E0985
Product name
Ethyl 2-Aminobenzothiazole-6-carboxylate
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$85
Updated
2025/07/31
TRC
Product number
E899730
Product name
Ethyl 2-Aminobenzothiazole-6-carboxylate
Packaging
1g
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA57269
Product name
2-Amino-1,3-benzothiazole-6-carboxylic acid ethyl ester
Packaging
2g
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
8H70-1-T8
Product name
Ethyl 2-amino-1,3-benzothiazole-6-carboxylate
Packaging
5G
Price
$90
Updated
2021/12/16
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Ethyl 2-amino-1,3-benzothiazole-6-carboxylate Chemical Properties,Usage,Production

Chemical Properties

yellow crystal

Uses

Ethyl 2-amino-benzothiazole-6-carboxylate (cas# 50850-93-6) is a compound useful in organic synthesis.

Synthesis

333-20-0

94-09-7

50850-93-6

Ethyl 4-aminobenzoate (4.9 g, 30.0 mmol) was dissolved with potassium thiocyanate (11.6 g, 120.0 mmol) in acetic acid (180 mL), followed by the slow dropwise addition of acetic acid solution (20 mL) containing bromine (1.5 mL, 30.0 mmol). The reaction was carried out at 19 °C and the titration process was controlled to be completed within 20 min. After the dropwise addition, the reaction system was gradually warmed up to room temperature and the reaction was continued with stirring overnight. Upon completion of the reaction, the reaction solution was slowly poured into water (100 mL) and stirred for 10 minutes. Subsequently, ammonium hydroxide solution was added dropwise to the mixture and the pH was adjusted to about 8. The reaction mixture was filtered and the resulting filter cake was washed sequentially with water. Finally, the product was dried under vacuum to give 6.7 g of yellow solid, ethyl 2-aminobenzo[d]thiazole-6-carboxylate in 100% yield. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO): δ 8.28 (d, J = 1.6 Hz, 1H), 7.88 (s, 2H), 7.82 (dd, J = 1.6 Hz, 8.4 Hz, 1H), 7.37 (d, J = 8.4 Hz, 1H), 4.29 (q, J = 7.2 Hz, 2H), 1.32 (t, J = 7.2 Hz, 3H).

References

[1] Patent: EP3401315, 2018, A1. Location in patent: Paragraph 0062; 0063
[2] Synlett, 2012, vol. 23, # 15, p. 2219 - 2222
[3] European Journal of Medicinal Chemistry, 2013, vol. 63, p. 702 - 712
[4] Medicinal Chemistry, 2017, vol. 13, # 4, p. 345 - 358
[5] European Journal of Medicinal Chemistry, 2013, vol. 61, p. 26 - 40

Ethyl 2-amino-1,3-benzothiazole-6-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 2-amino-1,3-benzothiazole-6-carboxylate Suppliers

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View Lastest Price from Ethyl 2-amino-1,3-benzothiazole-6-carboxylate manufacturers

Career Henan Chemical Co
Product
Ethyl 2-amino-1,3-benzothiazole-6-carboxylate 50850-93-6
Price
US $8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10tons
Release date
2018-12-24

50850-93-6, Ethyl 2-amino-1,3-benzothiazole-6-carboxylateRelated Search:

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  • IFLAB-BB F1981-0015
  • ETHYL 2-AMINO-BENZOTHIAZOLE-6-CARBOXYLATE
  • ETHYL 2-AMINO-1,3-BENZOTHIAZOLE-6-CARBOXYLATE
  • 6-Benzothiazolecarboxylicacid,2-amino-,ethylester(6CI,9CI)
  • AKOS BBS-00000329
  • 2-AMINO-6-ETHOXYCARBONYLBENZOTHIAZOLE
  • 2-AMINO-BENZOTHIAZOLE-6-CARBOXYLIC ACID ETHYL ESTER
  • TIMTEC-BB SBB010144
  • 2-Amino-6-(ethoxycarbonyl)-1,3-benzothiazole
  • Ethyl 2-aminobenzo[d]thiazole-6-carboxylate
  • 6-Benzothiazolecarboxylic acid, 2-amino-, ethyl ester
  • 2-amino-1,3-benzothiazole-6-carboxylic acid ethyl ester
  • Ethyl2-Aminobenzothiazole-6-carboxylate&gt
  • Ethyl2-aminobenzothiazole-6-carboxylate,97%
  • 3-benzothiazole-6-carboxylate
  • Ethyl 2-amino-1
  • 50850-93-6
  • BENZOTHIAZOLE