ChemicalBook > CAS DataBase List > Ethyl 2-hydroxybenzoate

Ethyl 2-hydroxybenzoate

Product Name
Ethyl 2-hydroxybenzoate
CAS No.
118-61-6
Chemical Name
Ethyl 2-hydroxybenzoate
Synonyms
ETHYL SALICYLATE;Mesotol;Ethyl salicyclate;Salotan;salethyl;Sal Ethyl;Ethyl Liu;FEMA 2458;salicylicether;Ethylsalicylat
CBNumber
CB1723193
Molecular Formula
C9H10O3
Formula Weight
166.17
MOL File
118-61-6.mol
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Ethyl 2-hydroxybenzoate Property

Melting point:
1 °C (lit.)
Boiling point:
234 °C (lit.)
Density 
1.131 g/mL at 25 °C (lit.)
vapor pressure 
0.05 mm Hg ( 25 °C)
refractive index 
n20/D 1.522(lit.)
FEMA 
2458 | ETHYL SALICYLATE
Flash point:
225 °F
storage temp. 
Store below +30°C.
solubility 
0.25g/l
form 
Liquid
pka
9.93±0.10(Predicted)
color 
Clear colorless to pale yellow
Odor
at 100.00 %. sweet wintergreen mint floral spicy balsam
Odor Type
minty
explosive limit
1.1%(V)
Water Solubility 
slightly soluble
Merck 
14,3850
JECFA Number
900
BRN 
907659
Dielectric constant
8.6（21℃）
InChIKey
GYCKQBWUSACYIF-UHFFFAOYSA-N
LogP
3.07 at 21.9℃
CAS DataBase Reference
118-61-6(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 2-hydroxy-, ethyl ester(118-61-6)
EPA Substance Registry System
Ethyl salicylate (118-61-6)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/38-52/53
Safety Statements 
26-36
WGK Germany 
1
RTECS 
VO3000000
TSCA 
Yes
HS Code 
29182390
Toxicity
LD50 orally in Rabbit: 1320 mg/kg LD50 dermal Rabbit > 5000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W245801
Product name
Ethyl salicylate
Purity
≥99%, FCC, FG
Packaging
1kg
Price
$40.1
Updated
2024/03/01
Sigma-Aldrich
Product number
W245801
Product name
Ethyl salicylate
Purity
≥99%, FCC, FG
Packaging
10Kg
Price
$325
Updated
2024/03/01
Sigma-Aldrich
Product number
W245801
Product name
Ethyl salicylate
Purity
≥99%, FCC, FG
Packaging
25kg
Price
$699
Updated
2024/03/01
Sigma-Aldrich
Product number
112291
Product name
Ethyl salicylate
Purity
99%
Packaging
100g
Price
$28
Updated
2024/03/01
Sigma-Aldrich
Product number
112291
Product name
Ethyl salicylate
Purity
99%
Packaging
250g
Price
$55.4
Updated
2024/03/01
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Ethyl 2-hydroxybenzoate Chemical Properties,Usage,Production

Description

Ethyl 2-hydroxdybenzoate is also known as Ethyl salicylate, which a kind of ester formed through the condensation between salicylic acid and ethanol. It can be used as a perfumery, artificial essence flavoring agent and used in cosmetics. It can also be used as analgesics, anti-inflammatory and antipyretic agents.

Chemical Properties

clear colourless to pale yellow liquid

Chemical Properties

Ethyl salicylate is the ester formed by the condensation of salicylic acid and ethanol. It is a clear liquid that is sparingly soluble in water, but soluble in alcohol and ether. It has a pleasant odor resembling winter green and is used in perfumery and artificial flavors.

Chemical Properties

Ethyl salicylate has a characteristic aromatic odor similar to wintergreen. It tends to darken on exposure to light and air.

Occurrence

Reported found in raspberry, tomato, currants, rum, whiskey, red wine, plum brandy, Cape gooseberry, Feijoa fruit, papaya and scotch.

Uses

manufacture of artificial perfumes.

Uses

Ethyl salicylate is a non-steroidal analgesic, anti-inflammatory and antirrheumatic drug. Its complexation with β-cyclodextrin was studied using reversed-phase liquid chromatography.

Uses

Ethyl salicylate may be used as an analytical standard for the determination of the analyte in biological fluids and topical formulation by chromatography-based techniques.

Definition

ChEBI: Ethyl salicylate is a hydroxybenzoic acid.

Production Methods

Ethyl salicylate is found naturally in currants and strawberries . It is manufactured commercially by the esterification of salicylic acid with ethyl alcohol.

Preparation

Ethyl 2-hydroxybenzoate is prepared by esterification of salicylic acid with ethyl alcohol and concentrated H2SO4 at 100°C in the presence of aluminum sulfate; by heating to the boil an alkaline solution of salicylic acid and ethyl p-toluenesulfonate.

Taste threshold values

Taste characteristics at 10 ppm: sweet, wintergreen, spicy and anisic.

General Description

Ethyl salicylate was hydrolysed to salicylic acid by the use of an extractive electrospray ionisation (EESI) device.

Flammability and Explosibility

Not classified

References

Sheu, Yaw-Wen, and Chein-Hsiun Tu. "Densities and viscosities of binary mixtures of ethyl acetoacetate, ethyl isovalerate, methyl benzoate, benzyl acetate, ethyl salicylate, and benzyl propionate with ethanol at T=(288.15, 298.15, 308.15, and 318.15) K." Journal of Chemical & Engineering Data 51.2 (2006): 545-553.
Filippa, Mauricio, Matías I. Sancho, and Estela Gasull. "Encapsulation of methyl and ethyl salicylates by β-cyclodextrin: HPLC, UV–vis and molecular modeling studies." Journal of pharmaceutical and biomedical analysis 48.3 (2008): 969-973.

Ethyl 2-hydroxybenzoate Preparation Products And Raw materials

Raw materials

Salicylic acid Ethanol Hydrochloric acid alcohol Ethyl p-toluenesulfonate Aluminum sulfate

Preparation Products

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Ethyl 2-hydroxybenzoate Suppliers

Belgium 2 China 328 France 2 Germany 13 India 35 Italy 3 Japan 7 Mexico 1 Singapore 1 Slovakia 1 South Africa 1 South Korea 1 Spain 2 Switzerland 3 Ukraine 1 United Kingdom 14 United States 57 USA 1 Venezuela 1 Global 474
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View Lastest Price from Ethyl 2-hydroxybenzoate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Ethyl 2-hydroxybenzoate 118-61-6
Price
US $0.00/KG
Min. Order
25KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-09
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Ethyl 2-Hydroxybenzoate 118-61-6
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-31
Hebei Weibang Biotechnology Co., Ltd
Product
Ethyl 2-hydroxybenzoate 118-61-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-01

118-61-6, Ethyl 2-hydroxybenzoateRelated Search:

Benzyl salicylate Isobutyl salicylate 2-HYDROXY-3-ISOPROPYLBENZOIC ACID Methyl salicylate Phenyl salicylate Sodium salicylate Amyl salicylate 2-Ethylhexyl salicylate isodecyl salicylate Methyl salicylate (+)-Bicuculline PHENETHYL SALICYLATE Ethyl 2-hydroxybenzoate Butyl salicylate Hexyl salicylate ACETYLSALICYLIC ANHYDRIDE Isopropyl salicylate 2-Methoxybenzoic acid ethyl ester

  • SALICYLIC ACID ETHYLESTER WITH GC
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  • salicylacidethylester
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  • salicylicether
  • salicylicethylester
  • Salotan
  • 2-ETHOXYCARBONYLPHENOL
  • 2-HYDROXYBENZOIC ACID ETHYL ESTER
  • FEMA 2458
  • LABOTEST-BB LT02097419
  • ETHYL 2-HYDROXYBENZOATE
  • ETHYL O-HYDROXYBENZOATE
  • ETHYL SALICYLATE
  • Ethyl sallicylate
  • Ethyl salicylate, 99+%
  • ethylsalicylate,benzoicacid2-hydroxy-ethylester
  • SALICYLIC ACID ETHYLESTER(SG)
  • Ethylsalicylat
  • ETHYL SALICYLATE 99+% FCC
  • SALICYLIC ACID ETHYL ESTER, SECONDARY STANDARD
  • Ethyl Salicylate &gt
  • ETHYL SALICYLATE FOR SYNTHESIS
  • Ethyl 2-hydroxybenzoate USP/EP/BP
  • Salicylic Acid Ethylester(AS)
  • Methyl Salicylate Impurity F
  • 118-61-6
  • 102-47-8
  • 2HOC6H4CO2C2H5
  • HOC6H4COOC2H5
  • Building Blocks
  • ACETATE
  • Carbonyl Compounds
  • C8 to C9
  • Esters
  • Organic Building Blocks
  • Heterocyclic Compounds
  • Aromatic Esters
  • Pharmaceutical Intermediates
  • 118-61-6