5-Chloroindole-3-carboxaldehyde
- Product Name
- 5-Chloroindole-3-carboxaldehyde
- CAS No.
- 827-01-0
- Chemical Name
- 5-Chloroindole-3-carboxaldehyde
- Synonyms
- TIMTEC-BB SBB003756;5-Chloro-3-formylindole;5-CHLOROINDOLE-3-ALDEHYDE;5-chloro-3-carboxaldehyde;5-Chloro-indol-3-carbaldehyde;5-Chloro-indole-3-carbaldehyde;5-CHLOROINDOLE-3-CARBOXALDEHYDE;5-Chloro-3-indolecarboxaldehyde;5-Chloro-1H-indol-3-carbaldehyde;5-CHLORO-1H-INDOLE-3-CARBALDEHYDE
- CBNumber
- CB1733606
- Molecular Formula
- C9H6ClNO
- Formula Weight
- 179.6
- MOL File
- 827-01-0.mol
5-Chloroindole-3-carboxaldehyde Property
- Melting point:
- 213-216 °C (lit.)
- Boiling point:
- 373.4±22.0 °C(Predicted)
- Density
- 1.431±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 14.59±0.30(Predicted)
- form
- powder
- color
- Light orange
- Sensitive
- Air Sensitive
- BRN
- 123794
- InChI
- InChI=1S/C9H6ClNO/c10-7-1-2-9-8(3-7)6(5-12)4-11-9/h1-5,11H
- InChIKey
- YXEXOIGXNYITQH-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(Cl)C=C2)C(C=O)=C1
- CAS DataBase Reference
- 827-01-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-36/37/39-22
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 533076
- Product name
- 5-Chloroindole-3-carboxaldehyde
- Purity
- 98%
- Packaging
- 5g
- Price
- $358
- Updated
- 2023/06/20
- Product number
- C3703
- Product name
- 5-Chloroindole-3-carboxaldehyde
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $93
- Updated
- 2025/07/31
- Product number
- C3703
- Product name
- 5-Chloroindole-3-carboxaldehyde
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $281
- Updated
- 2025/07/31
- Product number
- C380813
- Product name
- 5-Chloroindole-3-carboxaldehyde
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR28433
- Product name
- 5-Chloroindole-3-carboxaldehyde
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
5-Chloroindole-3-carboxaldehyde Chemical Properties,Usage,Production
Chemical Properties
Yellow to beige solid
Uses
5-Chloroindole-3-carboxaldehyde (5-Chloro-1H-indole-3-carboxaldehyde) may be used in the preparation of:
- 5-chloroindole-3-carboxaldehyde isonicotinoyl hydrazine
- 2′-[(5-chloro-1H-indol-3-yl)methyl-ene]-2-(1H-indol-3-yl)acetohydrazide
- 5-chloro-3-(2,2-dibromovinyl)-1-(2-trimethylsilylethoxymethyl)indole
It may also be used in the preparation of the following hydrazone derivatives:
- 5-chloroindole-3-carboxaldehyde 3-chlorobenzoylhydrazone
- 5-chloroindole-3-carboxaldehyde 4-nitrobenzoylhydrazone
- 5-chloroindole-3-carboxaldehyde 3-methylbenzoylhydrazone
- 5-chloroindole-3-carboxaldehyde 4-methylbenzoylhydrazone
General Description
5-Chloroindole-3-carboxaldehyde, also known as 5-chloro-1H-indole-3-carboxaldehyde, is an indole derivative.
Synthesis
17422-32-1
827-01-0
The general procedure for the synthesis of 5-chloroindole-3-carbaldehyde from 5-chloroindole was as follows: phosphorus trichloride (4.6 mL, 49 mmol) was added slowly and dropwise to stirred dimethylformamide (20 mL) at 0 °C. After the dropwise addition, the reaction mixture was continued to be stirred for 10 minutes. Subsequently, a solution of 5-chloroindole (5.0 g, 33 mmol) dissolved in dimethylformamide (5 mL) was added slowly dropwise. After completion of the dropwise addition, the reaction mixture was heated to 40°C and kept at this temperature for 45 minutes. After completion of the reaction, the mixture was cooled to room temperature and then treated with a solution of sodium hydroxide (5.9 g, 148 mmol) in water (20 mL). Next, the mixture was heated to 50°C, held for 10 minutes and then cooled to room temperature. The reaction mixture was poured into crushed ice (100 mL) and the precipitate was collected by filtration. Finally, the filter cake was recrystallized by methanol to give the white solid product 5-chloroindole-3-carboxaldehyde (3.5 g, 59% yield) with a melting point of 215-216 °C. Elemental analysis measured values: C, 60.13; H, 3.40; N, 7.75%. Consistent with theoretical values (C9H6ClNO): C, 60.19; H, 3.37; N, 7.79%.
References
[1] Patent: US6433175, 2002, B1
[2] Patent: US3953442, 1976, A
5-Chloroindole-3-carboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Chloroindole-3-carboxaldehyde manufacturers
- Product
- 5-Chloroindole-3-carboxaldehyde 827-01-0
- Price
- US $9.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2024-12-03
- Product
- 5-Chloroindole-3-carboxaldehyde 827-01-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-22
- Product
- 5-Chloroindole-3-carboxaldehyde 827-01-0
- Price
- US $5.00-0.20/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-02