Chemical Properties Application
ChemicalBook > CAS DataBase List > 2-Amino-1,3-propanediol

2-Amino-1,3-propanediol

Chemical Properties Application
Product Name
2-Amino-1,3-propanediol
CAS No.
534-03-2
Chemical Name
2-Amino-1,3-propanediol
Synonyms
2-AMINOPROPANE-1,3-DIOL;SERINOL;DL-SERINOL;Serinol 98%;S8002Dl-Serinol;2-Aminoglycerol;2-Amino-1,3-propaned;Silk ammonia alcohol;2-AMINO-1,3-PROPANDIOL;2-Aminopropan-1,3-diol
CBNumber
CB1738085
Molecular Formula
C3H9NO2
Formula Weight
91.11
MOL File
534-03-2.mol
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2-Amino-1,3-propanediol Property

Melting point:
52-55 °C (lit.)
Boiling point:
277 °C (lit.)
Density 
1.1278 (rough estimate)
vapor pressure 
0.01Pa at 25℃
refractive index 
1.4698 (estimate)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Soluble, Sonicated), Methanol (Slightly, Sonicated), Water (Slightly)
pka
12.24±0.10(Predicted)
form 
Adhering Crystalline Powder
color 
White to off-white
Water Solubility 
Soluble in water and alcohol.
Sensitive 
Hygroscopic
BRN 
635683
Stability:
Hygroscopic
InChIKey
KJJPLEZQSCZCKE-UHFFFAOYSA-N
LogP
-1.82 at 20℃
CAS DataBase Reference
534-03-2(CAS DataBase Reference)
NIST Chemistry Reference
2-Amino-1,3-propanediol(534-03-2)
EPA Substance Registry System
1,3-Propanediol, 2-amino- (534-03-2)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34
Safety Statements 
26-27-28-36/37/39-45
RIDADR 
UN 3263 8/PG 2
WGK Germany 
1
3-10-34
Hazard Note 
Corrosive
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29221990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
357898
Product name
Serinol
Purity
98%
Packaging
5g
Price
$112
Updated
2024/03/01
Sigma-Aldrich
Product number
357898
Product name
Serinol
Purity
98%
Packaging
1g
Price
$50.3
Updated
2023/06/20
TCI Chemical
Product number
A1252
Product name
2-Amino-1,3-propanediol
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$51
Updated
2024/03/01
TCI Chemical
Product number
A1252
Product name
2-Amino-1,3-propanediol
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$149
Updated
2024/03/01
Alfa Aesar
Product number
L08426
Product name
2-Amino-1,3-propanediol, 98%
Packaging
5g
Price
$61.65
Updated
2024/03/01
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2-Amino-1,3-propanediol Chemical Properties,Usage,Production

Chemical Properties

2-amino-1, 3-propanediol, which carries the trivial name of serinol, is an organic compound from the group of alkanolamines.The name serinol was chosen because of the structural similarity to the amino acidserine. In extension, derivatives thereof with substituents on the carbons of serinol are also called serinols.Under standard conditions, it is a solid, which is very soluble in water. 2-amino-1, 3-propanediol is a very stable, hygroscopic and corrosive substance.

Application

  • In biological field, the amino alcohol structure is widely found in many drugs especially antihistamines.
  • Serinol is used as an intermediate for non-ionic X-ray contrast agents like iopamidol (1-N,3-N-bi's (1,3-dihydroxypropan-2-yl) -5-[(2S) -2-hydroxypropanamido] -2,4,6-triiodobenzene-1,3-di-carboxamide, which is for example distributed as iopamiro®, isovue® (both Bracco Diagnostics Inc.) or scanlux® (Sanochemia). Iopamidol is employed as a contrast agent for angiography throughout the cardiovascular system.
  • Except the application in biochemical field, Serinol is used for the production of efficient anionic emulsifiers and nonionic polyethylene emulsions. It appears in personal care product formulations and show better base strength, lower neutral equivalent, and lower volatility than traditional amine emulsifiers.Furthermore, serinol constitutes a precursor for drugs dealing with pain treatment.
  • The difunctionality of serinol makes it useful as raw materials in polymer applications in both water- and solvent-based to increase the solubility of other components and improve solution stability. It functions as a pigment dispersion-aid dispersant to enhance the wetting and viscosity stability.
  • Serinol maintains a constant alkalinity in the boiling water flows and condensate not to form solid products which would impede line flow. It is applied for corrosion Inhibits. So it is widely employed in the preparation of water soluble cationic flocculants and ion exchange resins which adsorb solid and colloidal particles by electrostatic attraction. It is also used for water treatment, metal treatment and absorption of CO2 gas.

Description

2-Amino-1,3-propanediol (2-APD, also known as serinol) is a high-value-added chemical that is used as a building block for the synthesis of a variety of compounds, including drugs to treat type 2 diabetes mellitus, the antibiotic chloramphenicol, immune multiple sclerosis, and a new generation of nonionic X-ray contrast agents.

Chemical Properties

white to off-white adhering crystalline powder

Uses

2-Amino-1,3-propanediol is used as an intermediate in several chemical applications and also useful for serinol and some of its derivatives.

Uses

Serinol may be used to prepare the artificial nucleic acids. It may be used in the synthesis of N-acylated serinol and C16-serinol affinity gel.

Preparation

Add 20% 2-nitro-1,3-propanediol methanol solution (1250 g) to 5% palladium/carbon 3.5 g. Hydrogen (70 L, pressure 3MPa) was continuously introduced and reacted at 75°C for 5 hours to obtain serine alcohol solution. The serine alcohol solution is pumped into a high vacuum distillation vessel, vacuumed to 40 pa, and methanol is distilled for reuse. Yield = 97.2%.

Biosynthesis

Currently, the manufacture of 2-Amino-1,3-propanediol (2-APD) predominantly relies on chemical processes by utilizing fossil fuel-derived and highly explosive raw materials. In addition to chemical synthesis, its synthesis can also rely on biosynthesis. Luo et al. established an artificial biosynthetic pathway for converting glucose to 2-APD in a metabolically engineered Escherichia coli. This artificial pathway employs an engineered heterogeneous aminotransferase RtxA for diverting dihydroxyacetone phosphate (DHAP) to generate 2-APD phosphate and an endogenous phosphatase for converting it into the target product 2-APD. 2-APD-P is 2-amino-1,3-propanediol phosphate[1].

Origin

In the 1970s, 2-Amino-1,3-propanediol (2-APD) was first reported to be a molecular building block of the natural products rhizobitoxine and dihydrorhizobitoxine produced by the legume symbiont Rhizobium japonicum[1].

General Description

Serinol activates toxin production in the attenuated cultures of Helminthosporium sacchari. Preparation of polyesters derived from serinol is reported.

References

[1] Luo Y, et al. An Artificial Biosynthetic Pathway for 2?Amino-1,3-Propanediol Production Using Metabolically Engineered Escherichia coli. ACS Synthetic Biology, 2019; 8: 548–556.

2-Amino-1,3-propanediol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Amino-1,3-propanediol manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
L-Ser-Ol 534-03-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-01-17
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Amino-1,3-propanediol 534-03-2
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000kgs
Release date
2021-08-13
airuikechemical co., ltd.
Product
2-amino-1,3-propanediol 534-03-2
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-03-29

534-03-2, 2-Amino-1,3-propanediolRelated Search:


  • SERINOL
  • 1,3-Propanediol, 2-amino-
  • DL-SERINOL
  • 2-AMINOPROPANE-1,3-DIOL
  • 2-Amino 1, 3-Propanediol /Serinol (CAS NO: 534-03-2) (Diacetoxyiodo)benzene / Iodobenzene Diacetate ( CAS No : 3240-34-4)
  • 2-AMINO-1,3-PROPANDIOL
  • 2-AMINO-1,3-PROPANEDIOL
  • 2-Aminopropan-1,3-propanediol
  • 2-Amino-1,3-dihydroxypropane
  • Serinol[2-Amino-1,3-Propandiol]
  • S8002Dl-Serinol
  • 2-Amino-1,3-Propanediol(Serinol)
  • 2-Amino-1,3-propanediol 99%
  • 2-Aminopropan-1,3-diol
  • 2-AMINO-1,3-PROPANDIOL (SERINOL)
  • 1,3-Dihydroxy-2-propylamine
  • 1,3-Dihydroxyisopropylamine
  • 2-Aminoglycerol
  • 2-Amino-1,3-propanediol,98%
  • 2-Amino-1,3-propanediol ,99%
  • 2-Amino-1,3-propaned
  • 2-Aminopropane-1,3-diol 99%
  • 2-aMlno-1,3-propanedio
  • Serinol 98%
  • Serinol, 2-Amino-1,3-dihydroxypropane
  • 2-Amino-1,3-propanediol (APD)
  • 2-Amino-1,3-propanediol &gt
  • 2-Amino-1,3-propanediol USP/EP/BP
  • Silk ammonia alcohol
  • Serinol/2-amino-1,3-propanediol
  • 2-Amino-1,3-Prpanediol
  • 534-03-2
  • HOCH2CHNH2CH2OH
  • Building Blocks
  • Amino Alcohols
  • AMINE
  • Organic Building Blocks
  • Oxygen Compounds
  • API intermediates
  • Alcohols and Derivatives
  • Pharmaceutical Intermediates
  • Intermediate
  • bc0001
  • 534-03-2
  • Amino Acid