ChemicalBook > CAS DataBase List > D-Alanine Methyl Ester Hydrochloride

D-Alanine Methyl Ester Hydrochloride

Product Name
D-Alanine Methyl Ester Hydrochloride
CAS No.
14316-06-4
Chemical Name
D-Alanine Methyl Ester Hydrochloride
Synonyms
METHYL D-ALANINATE HYDROCHLORIDE;D-ALANINE METHYL ESTER HCL;(R)-Methyl 2-aminopropanoate hydrochloride;D-Alanina;Nsc523192;D-Ala-OMe HCl;H-D-ALA-OME HCL;D-ALANINE-OME HCL;Acetyl Bromide LR;D-Alanine Methyl Est
CBNumber
CB1742495
Molecular Formula
C4H10ClNO2
Formula Weight
139.58
MOL File
14316-06-4.mol
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D-Alanine Methyl Ester Hydrochloride Property

Melting point:
108-110 °C(lit.)
alpha 
-8 º (c=1.6, MeOH)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Sparingly), Methanol (Sparingly), Water (Slightly)
form 
Crystalline Powder
color 
White to off-white
optical activity
[α]20/D 8.0°, c = 1.6 in methanol
Water Solubility 
Soluble in Water 100 mg/ml.
InChI
InChI=1/C4H9NO2.ClH/c1-3(5)4(6)7-2;/h3H,5H2,1-2H3;1H/t3-;/s3
InChIKey
IYUKFAFDFHZKPI-DFWYDOINSA-N
SMILES
C(OC)(=O)[C@@H](C)N.[H]Cl |&1:4,r|
CAS DataBase Reference
14316-06-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Safety Statements 
24/25
WGK Germany 
3
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
414549
Product name
D-Alanine methyl ester hydrochloride
Purity
98%
Packaging
5g
Price
$53.06
Updated
2025/07/31
Sigma-Aldrich
Product number
414549
Product name
D-Alanine methyl ester hydrochloride
Purity
98%
Packaging
25g
Price
$97.3
Updated
2025/07/31
TCI Chemical
Product number
A2011
Product name
D-Alanine Methyl Ester Hydrochloride
Purity
>97.0%(N)(T)
Packaging
5g
Price
$30
Updated
2025/07/31
TCI Chemical
Product number
A2011
Product name
D-Alanine Methyl Ester Hydrochloride
Purity
>97.0%(N)(T)
Packaging
25g
Price
$103
Updated
2025/07/31
Usbiological
Product number
237097
Product name
D-Alanine methyl ester hydrochloride 98+%
Packaging
5g
Price
$159
Updated
2021/12/16
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D-Alanine Methyl Ester Hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

D-Alanine methyl ester hydrochloride is used as building block for the preparation of peptides.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

338-69-2

14316-06-4

GENERAL PROCEDURE: Thionyl chloride (SOCl?, 21.8 mL, 0.3 mol) and (S)-alanine (8.91 g, 0.1 mol) were added sequentially to methanol (CH?OH, 100 mL), and the reaction was stirred for 2 hours at room temperature. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in methanol (30 mL) and again distilled under reduced pressure to remove the organic solvent. This dissolution-distillation process was repeated twice. The final colorless amorphous solid product, D-alanine methyl ester hydrochloride, was obtained with a melting point of 103 °C (literature value 98-99 °C) and a yield of 14.3 g (yield >99%).

References

[1] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 17, p. 4778 - 4799
[2] Organic Preparations and Procedures International, 2002, vol. 34, # 1, p. 87 - 94
[3] Tetrahedron Letters, 1989, vol. 30, # 3, p. 313 - 316
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 15, p. 6293 - 6305
[5] European Journal of Organic Chemistry, 2010, # 22, p. 4276 - 4287

D-Alanine Methyl Ester Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

2,5-Dimethylpiperazine
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View Lastest Price from D-Alanine Methyl Ester Hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
D-Alanine Methyl Ester Hydrochloride 14316-06-4
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kg
Release date
2021-08-24
Hebei Chuanghai Biotechnology Co., Ltd
Product
D-Alanine Methyl Ester Hydrochloride 14316-06-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-13
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
D-Ala-Ome.Hcl 14316-06-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-02-28

14316-06-4, D-Alanine Methyl Ester HydrochlorideRelated Search:

L-Alanine EC 2.6.1.2 Methyl acrylate Topotecan hydrochloride D-Alanine Phenprobamate Tribenuron methyl METSULFURON METHYL Methyl salicylate Methyl acetate Kresoxim-methyl D-Phenylalanine methyl ester hydrochloride D-Alanine tert-butyl ester hydrochloride D-Prolinamide D-Alanyl-D-alanine D-Phenylalanine Thiophanate-methyl Methyl

  • METHYL D-ALANINATE HYDROCHLORIDE
  • H-D-ALA-OME HCL
  • D-2-AMINOPROPIONIC ACID METHYL ESTER HYDROCHLORIDE
  • D-ALA METHYL ESTER HCL
  • D-ALANINE METHYL ESTER HCL
  • D-ALANINE METHYL ESTER HYDROCHLORIDE
  • D-ALANINE METHYL ESTER HYDROCHLORIDE SALT
  • D-ALANINE-OME HCL
  • D-Ala-OMe HCl
  • D-Alanina
  • D-ALANINAMETHYLESTERHCL(D-PHENYLALANINEMETHYLESTERHCL)
  • (R)-2-Aminopropionic Acid Methyl Ester Hydrochloride
  • Methyl (R)-2-Aminopropionate Hydrochloride
  • 2-Aminopropionic Acid Methyl Ester Hydrochloride
  • Nsc523192
  • D-Alanine methyl ester hydrochloride ,98%
  • D-Alanine Methyl Est
  • Methyl (R)-2-Aminopropionate Hydrochloride (R)-2-Aminopropionic Acid Methyl Ester Hydrochloride H-D-Ala-OMe.HCl
  • Methyl (2R)-2-aminopropanoate hydrochloride, Methyl (2R)-2-aminopropionate hydrochloride
  • D-Alanine Metyl ester hydrochloride
  • D-Alanine methyl ester hydrochloride 98%
  • (R)-Methyl 2-aminopropanoate hydrochloride
  • D-Alanine methyl ester hydrochloride≥ 98% (HPLC)
  • (R)-Methyl 2-aminopropionate hydrochloride
  • D-Alanine Methyl Ester Hydrochloride,99%e.e.
  • D-Alanine, methylester, hydrochloride (1:1)
  • D-Alanine Methyl Ester Hydrochloride &gt
  • D-Alanine Methyl Ester Hydrochloride USP/EP/BP
  • (R)-METHYL 2-AMINOPROPANOATE HCL
  • H-D-Ala-OMe (hydrochloride)
  • D-Alanine, methyl ester, hydrochloride (9CI)
  • methyl (2R)-2-aminopropanoate
  • Acetyl Bromide LR
  • <sc>D</sc>-Alanine methyl ester hydrochloride
  • 14316-06-4
  • C4H9NO2HCI
  • C4H9NO2ClH
  • CH3CHNH2CO2CH3HCl
  • AMINE
  • Alanine
  • Amino Acid Derivatives
  • Peptide Synthesis
  • Specialty Synthesis
  • amino
  • Alanine [Ala, A]
  • Amino Acids and Derivatives
  • Amino Acids Derivatives
  • Amino Acids
  • Amino Acid Methyl Esters
  • Amino Acids (C-Protected)
  • Biochemistry
  • Amino hydrochloride
  • Alanine
  • Amino Acid Derivatives
  • Peptide Synthesis
  • 14316-06-4