ChemicalBook > CAS DataBase List > 1H-INDAZOLE-4-CARBOXYLIC ACID

1H-INDAZOLE-4-CARBOXYLIC ACID

Product Name
1H-INDAZOLE-4-CARBOXYLIC ACID
CAS No.
677306-38-6
Chemical Name
1H-INDAZOLE-4-CARBOXYLIC ACID
Synonyms
4-Carboxy-1H-indazole;4-INDAZOLECARBOXYLIC ACID;INDAZOLE-4-CARBOXYLIC ACID;Indazole-4-carboxylic aci...;1H-INDAZOLE-4-CARBOXYLIC ACID;4-(1H)INDAZOLE CARBOXYLIC ACID;1H-Indazole-4-Carboxylic Acid(WX614188)
CBNumber
CB1744277
Molecular Formula
C8H6N2O2
Formula Weight
162.15
MOL File
677306-38-6.mol
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1H-INDAZOLE-4-CARBOXYLIC ACID Property

Melting point:
ca 280℃
Boiling point:
443.7±18.0 °C(Predicted)
Density 
1.506±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
3.35±0.30(Predicted)
form 
Crystalline Powder
color 
White to cream
InChI
InChI=1S/C8H6N2O2/c11-8(12)5-2-1-3-7-6(5)4-9-10-7/h1-4H,(H,9,10)(H,11,12)
InChIKey
KGKZHHIUOZGUNP-UHFFFAOYSA-N
SMILES
N1C2=C(C(C(O)=O)=CC=C2)C=N1
CAS DataBase Reference
677306-38-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-36-22
Safety Statements 
26-36/37/39
WGK Germany 
3
HS Code 
29339980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
729752
Product name
1H-Indazole-4-carboxylic acid
Purity
97%
Packaging
1g
Price
$96.98
Updated
2025/07/31
TRC
Product number
I509045
Product name
1H-Indazole-4-carboxylic acid
Packaging
1g
Price
$75
Updated
2021/12/16
Usbiological
Product number
412389
Product name
1H-Indazole-4-carboxylic acid
Packaging
100mg
Price
$305
Updated
2021/12/16
Usbiological
Product number
280960
Product name
1H-Indazole-4-carboxylic acid
Packaging
500mg
Price
$333
Updated
2021/12/16
SynQuest Laboratories
Product number
4H21-1-C8
Product name
1H-Indazole-4-carboxylic acid
Packaging
1g
Price
$26
Updated
2021/12/16
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1H-INDAZOLE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

186407-74-9

677306-38-6

The general procedure for the synthesis of indazole-4-carboxylic acid from 4-bromo-1H-indazole was as follows: sodium hydride (60% dispersed in mineral oil, 1.11 eq.) was added batchwise to an anhydrous tetrahydrofuran (7 L/mol) solution of 4-bromo-1H-indazole (1.00 eq.) at room temperature. The resulting solution was stirred at room temperature for 30 minutes and subsequently cooled to -60°C. A cyclohexane solution of 1.3 M sec-butyl lithium (2.1 eq.) was slowly added while keeping the internal temperature below -50 °C. Stirring of the reaction mixture was continued at -50 °C for 2 hours. Subsequently, a steady stream of anhydrous carbon dioxide gas was passed into the reaction mixture for 1 hour. While maintaining the carbon dioxide gas stream, the reaction mixture was allowed to gradually warm up to room temperature. Brine (6 L/mol) was added and the pH of the mixture was adjusted with concentrated hydrochloric acid to 5. The mixture was extracted with warm ethyl acetate (3 x 8 L/mol), the organic phases were combined, washed with a small amount of brine, dried over anhydrous sodium sulfate and concentrated. Finally, indazole-4-carboxylic acid was purified by silica gel column chromatography or crystallization.

References

[1] Patent: WO2004/29050, 2004, A1. Location in patent: Page 103;104

1H-INDAZOLE-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-INDAZOLE-4-CARBOXYLIC ACID Suppliers

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View Lastest Price from 1H-INDAZOLE-4-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co
Product
1H-INDAZOLE-4-CARBOXYLIC ACID 677306-38-6
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
as request
Release date
2018-12-24

677306-38-6, 1H-INDAZOLE-4-CARBOXYLIC ACIDRelated Search:

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