3-Phenylpyruvic acid Property

Melting point:

150-154 °C (lit.)

Boiling point:

299.1±19.0 °C(Predicted)

Density 

1.257±0.06 g/cm3(Predicted)

FEMA 

3892 | 2-OXO-3-PHENYLPROPIONIC ACID

storage temp. 

-20°C

solubility 

Soluble in DMSO

pka

2.61±0.54(Predicted)

form 

powder to crystal

color 

White to Light yellow

Odor

at 100.00 %. sweet acidic honey almond weedy phenolic green

Odor Type

honey

Sensitive 

Light & Air Sensitive & Hygroscopic

JECFA Number

1479

BRN 

2207312

LogP

0.54

CAS DataBase Reference

156-06-9(CAS DataBase Reference)

NIST Chemistry Reference

Benzenepropanoic acid, «alpha»-oxo-(156-06-9)

EPA Substance Registry System

Phenylpyruvic acid (156-06-9)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-24/25-36-26

WGK Germany 

3

F 

3-8-10-23

HS Code 

29183000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H330Fatal if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P285In case of inadequate ventilation wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304IF INHALED:

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P362Take off contaminated clothing and wash before reuse.

P370+P378In case of fire: Use … for extinction.

P403Store in a well-ventilated place.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

3-Phenylpyruvic acid Chemical Properties,Usage,Production

Uses

α-Oxobenzenepropanoic Acid is a useful reagent for organic synthesis.

Definition

ChEBI: A 2-oxo monocarboxylic acid that is 3-phenylpropanoic acid substituted by an oxo group at position 2. It is an intermediate metabolite in the phenylalanine pathway.

General Description

Phenylpyruvic acid reduces glucose-6-phosphate dehydrogenase activity without pre-incubation.

Purification Methods

Recrystallise the acid from *C6H6. The phenylhydrazone has m 173o [Zeller Helv Chim Acta 26 1614 1943, Hopkins & Chisholm Can J Research [B] 24 89 1946]. The 2,4-dinitrophenylhydrazone has m 162-164o (189o, 192-194o) [Fones J Org Chem 17 1952]. [Beilstein 10 IV 2760.]