2-CHLORO-5-FLUORO-3-NITROPYRIDINE

Product Name: 2-CHLORO-5-FLUORO-3-NITROPYRIDINE
CAS No.: 136888-21-6
Chemical Name: 2-CHLORO-5-FLUORO-3-NITROPYRIDINE
Synonyms: 2-CHLORO-5-FLUORO-3-NITROPYRIDINE;2-CHLORO-3-NITRO-5-FLUOROPYRIDINE;Pyridine, 2-chloro-5-fluoro-3-nitro-;2-CHLORO-5-FLUORO-3-NITROPYRIDINE ISO 9001：2015 REACH
CBNumber: CB1769379
Molecular Formula: C5H2ClFN2O2
Formula Weight: 176.53
MOL File: 136888-21-6.mol

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2-CHLORO-5-FLUORO-3-NITROPYRIDINE Property

Melting point:: 48.0 to 52.0 °C
Boiling point:: 246℃
Density: 1.595
Flash point:: 103℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
pka: -4.94±0.10(Predicted)
color: White to Yellow to Green
InChI: InChI=1S/C5H2ClFN2O2/c6-5-4(9(10)11)1-3(7)2-8-5/h1-2H
InChIKey: SVVZGNAZMPSGMU-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(F)C=C1[N+]([O-])=O

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3115
Product name: 2-Chloro-5-fluoro-3-nitropyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $267
Updated: 2025/07/31

TCI Chemical

Product number: C3115
Product name: 2-Chloro-5-fluoro-3-nitropyridine
Purity: >98.0%(GC)
Packaging: 200mg
Price: $78
Updated: 2025/07/31

TRC

Product number: C585753
Product name: 2-Chloro-5-fluoro-3-nitropyridine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: C585753
Product name: 2-Chloro-5-fluoro-3-nitropyridine
Packaging: 500mg
Price: $130
Updated: 2021/12/16

Apolloscientific

Product number: PC50086
Product name: 2-Chloro-5-fluoro-3-nitropyridine
Packaging: 5g
Price: $88
Updated: 2021/12/16

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2-CHLORO-5-FLUORO-3-NITROPYRIDINE Chemical Properties,Usage,Production

Chemical Properties

light powder

Synthesis

136888-20-5

136888-21-6

General procedure for the synthesis of 2-chloro-5-fluoro-3-nitropyridine from 2-hydroxy-3-nitro-5-fluoro-pyridine: 2-hydroxy-3-nitro-5-fluoro-pyridine (1.00 g, 5.33 mmol) was dissolved in acetonitrile (40 mL), followed by the addition of a solution of tetraethylammonium chloride (2.10 g, 12.65 mmol) in acetonitrile. After the mixture was clarified, phosphorus trichloride (1.94 g, 12.65 mmol) was added slowly and dropwise at room temperature. The reaction mixture was heated to 90°C and maintained for 24 hours. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The residue was dissolved in water (100 mL) and extracted with ethyl acetate (2 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure to give a yellow solid product (0.90 g, 69% yield), which was pure enough to be used directly in subsequent synthesis steps. Low resolution mass spectrometry (LRMS) showed m/z: 177 ([M+H]+).

References

[1] Patent: US2011/28467, 2011, A1. Location in patent: Page/Page column 52
[2] Patent: EP2518071, 2012, A1. Location in patent: Page/Page column 43
[3] Patent: WO2006/114706, 2006, A1. Location in patent: Page/Page column 45
[4] Journal of Heterocyclic Chemistry, 1996, vol. 33, # 2, p. 287 - 293
[5] Patent: US2004/110785, 2004, A1. Location in patent: Page 77

2-CHLORO-5-FLUORO-3-NITROPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-5-FLUORO-3-NITROPYRIDINE Suppliers

Americas 1 China 123 Europe 1 France 1 Germany 1 India 4 Japan 1 United Kingdom 3 United States 18 Global 153

Pure Chemistry Scientific Inc.

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View Lastest Price from 2-CHLORO-5-FLUORO-3-NITROPYRIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-CHLORO-5-FLUORO-3-NITROPYRIDINE 136888-21-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Career Henan Chemical Co

Product: 2-CHLORO-5-FLUORO-3-NITROPYRIDINE 136888-21-6
Price: US $1.00-2.00/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2019-08-28

136888-21-6, 2-CHLORO-5-FLUORO-3-NITROPYRIDINERelated Search:

2-Chloro-5-fluoro-3-methylpyridine 2-Chloro-4-iodopyridine 2-Chloro-4-nitropyridine 1-oxide 2-Chloro-5-iodopyridine 2-Chloro-4-methyl-5-nitropyridine 2-Chloro-4-fluoropyridine 3-Amino-6-chloro-2-picoline 3-AMINO-6-CHLORO-4-PICOLINE 2-CHLORO-5-FLUORO-6-PICOLINE 2-Chloro-5-fluoro-4-methyl-pyridine Forchlorfenuron 2-CHLORO-3-FLUORO-4-NITROPYRIDINE N-OXIDE 5-CHLORO-2-FLUORO-3-NITROPYRIDINE 3-Amino-5-fluoropyridine 3-AMINO-2-CHLORO-5-FLUOROPYRIDINE 2-CHLORO-5-FLUORO-3-NITROPYRIDINE 2-CHLORO-5-FLUORO-3-NITRO-4-PICOLINE 2-CHLORO-3-FLUORO-4-NITROPYRIDINE

2-CHLORO-3-NITRO-5-FLUOROPYRIDINE

2-CHLORO-5-FLUORO-3-NITROPYRIDINE

Pyridine, 2-chloro-5-fluoro-3-nitro-

2-CHLORO-5-FLUORO-3-NITROPYRIDINE ISO 9001：2015 REACH

136888-21-6

Fluorine series

Boronic Acid

Pyridine

Pyridines