ChemicalBook > CAS DataBase List > ISOQUINOLINE-1-CARBALDEHYDE

ISOQUINOLINE-1-CARBALDEHYDE

Product Name: ISOQUINOLINE-1-CARBALDEHYDE
CAS No.: 4494-18-2
Chemical Name: ISOQUINOLINE-1-CARBALDEHYDE
Synonyms: Isoquinaldaldehyde;1-FORMYLISOQUINOLINE;1-Isoquinolinecarbaldehyde;1-isquinolinecarboxaldehyde;ISOQUINOLINE-1-CARBALDEHYDE;1-Isoquinolinecarboxaldehyde;Isoquinoline-1-carboxaldehyde;Isoquinoline-1-carbaldehyde ,97%;1-Formylisoquinoline, CAS 4494-18-2;ISOQUINOLINE-1-CARBALDEHYDE ISO 9001：2015 REACH
CBNumber: CB1777626
Molecular Formula: C10H7NO
Formula Weight: 157.17
MOL File: 4494-18-2.mol

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ISOQUINOLINE-1-CARBALDEHYDE Property

Melting point:: 55-55.5 °C
Boiling point:: 308.6±15.0 °C(Predicted)
Density: 1.223±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: 2.06±0.30(Predicted)
Appearance: Off-white to pink Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22-36-20/21/22
Safety Statements: 26-36/37-24/25
HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: I918515
Product name: Isoquinoline-1-carbaldehyde
Packaging: 250mg
Price: $220
Updated: 2021/12/16

Activate Scientific

Product number: AS16019
Product name: Isoquinoline-1-carbaldehyde
Purity: 95+%
Packaging: 1g
Price: $272
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK590296
Product name: Isoquinoline-1-carbaldehyde
Purity: 97%
Packaging: 250mg
Price: $310
Updated: 2021/12/16

AK Scientific

Product number: Y6656
Product name: Isoquinoline-1-carbaldehyde
Packaging: 1g
Price: $330
Updated: 2021/12/16

Apolloscientific

Product number: OR953813
Product name: Isoquinoline-1-carbaldehyde
Purity: 95%
Packaging: 250mg
Price: $370
Updated: 2021/12/16

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ISOQUINOLINE-1-CARBALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

Yellow solid

Synthesis

1721-93-3

4494-18-2

1. Synthesis of 1-isoquinolinecarboxaldehyde: 1-methylisoquinoline (300 mg, 2.10 mmol) was dissolved in 1,4-dioxane (20 mL). Selenium dioxide (323 mg, 2.91 mmol) was added to the solution, followed by heating and refluxing under nitrogen protection for 1.5 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was filtered through diatomaceous earth. The filtrate was distilled under reduced pressure to remove the solvent. The resulting residue was purified by silica gel column chromatography using n-hexane/ethyl acetate (5:1, v/v) as eluent, and the eluent grades containing the target product were collected, resulting in 1-isoquinolinecarboxaldehyde (252 mg, 77% yield) as a white solid. The structure of the product was confirmed by 1H-NMR (CDCl3) δ: 7.73-7.79 (m, 2H), 7.88-7.93 (m, 2H), 8.74-8.76 (m, 1H), 9.30-9.33 (m, 1H), 10.39 (s, 1H) and MS (ESI) m/z 158 (M++1).

References

[1] Patent: EP1346982, 2003, A1
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 3, p. 1201 - 1212
[3] Journal of Medicinal Chemistry, 2018, vol. 61, # 7, p. 2753 - 2775
[4] Organic and Biomolecular Chemistry, 2012, vol. 10, # 6, p. 1239 - 1245
[5] Patent: CN103570683, 2018, B. Location in patent: Paragraph 0221; 0226-0228

ISOQUINOLINE-1-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ISOQUINOLINE-1-CARBALDEHYDE manufacturers

Shanghai Rlavie Technology Co ltd

Product: Isoquinoline-1-carbaldehyde 4494-18-2
Price: US $0.00/KG
Min. Order: 0.0001KG
Purity: 98%min
Supply Ability: 500kgs/month
Release date: 2022-05-11

Career Henan Chemical Co

Product: ISOQUINOLINE-1-CARBALDEHYDE 4494-18-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-03

Career Henan Chemical Co

Product: ISOQUINOLINE-1-CARBALDEHYDE 4494-18-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-03

4494-18-2, ISOQUINOLINE-1-CARBALDEHYDERelated Search:

Isoquinoline-1-carboxylic acid ISOQUINOLINE-5-CARBALDEHYDE ISOQUINOLINE-4-CARBALDEHYDE Isoquinoline-3-carbaldehyde Isoquinoline-5-sulphonyl chloride hydrochloride ISOQUINOLINE-5-SULFONYL CHLORIDE Isoquinolin-3-ylMethanaMine hydrochloride 1-ISOQUINOLINEMETHANOL ISOQUINOLINE-1-CARBOXYLIC ACID METHYL ESTER Isoquinoline-3-carboxylic acid ISOQUINOLINE-1,3,4-TRIONE 7-Isoquinolinecarbonitrile(9CI) 6-Isoquinolinecarboxaldehyde (9CI) ISOQUINOLINE N-OXIDE 8-Isoquinolinecarbonitrile(9CI) ETHYL ISOQUINOLINE-3-CARBOXYLATE ISOQUINOLINE-5-CARBOXYLIC ACID 7-Isoquinolinecarboxaldehyde (6CI,9CI)

ISOQUINOLINE-1-CARBALDEHYDE

1-isquinolinecarboxaldehyde

1-FORMYLISOQUINOLINE

1-Isoquinolinecarboxaldehyde

Isoquinoline-1-carbaldehyde ,97%

Isoquinoline-1-carboxaldehyde

ISOQUINOLINE-1-CARBALDEHYDE ISO 9001：2015 REACH

1-Isoquinolinecarbaldehyde

Isoquinaldaldehyde

1-Formylisoquinoline, CAS 4494-18-2

4494-18-2

Isoquinoline Derivertives