ChemicalBook > CAS DataBase List > 8-BROMO-IMIDAZO[1,2-A]PYRIDINE

8-BROMO-IMIDAZO[1,2-A]PYRIDINE

Product Name
8-BROMO-IMIDAZO[1,2-A]PYRIDINE
CAS No.
850349-02-9
Chemical Name
8-BROMO-IMIDAZO[1,2-A]PYRIDINE
Synonyms
8-BROMO-IMIDAZO[1,2-A]PYRIDINE;8-broMoH-iMidazo[1,2-a]pyridine;IMidazo[1,2-a]pyridine,8-broMo-;8-Bromoimidazo[1,2-a]pyridine,97%;8-Bromoimidazo[1,2-a]pyridine;8-BROMO-IMIDAZO[1,2-A]PYRIDINE ISO 9001：2015 REACH
CBNumber
CB1790481
Molecular Formula
C7H5BrN2
Formula Weight
197.03
MOL File
850349-02-9.mol
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8-BROMO-IMIDAZO[1,2-A]PYRIDINE Property

Melting point:
70-75℃
Density 
1.69
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
solid
pka
3.85±0.50(Predicted)
Appearance
Light yellow to green yellow Solid
InChI
InChI=1S/C7H5BrN2/c8-6-2-1-4-10-5-3-9-7(6)10/h1-5H
InChIKey
GCCVNNZARPFXES-UHFFFAOYSA-N
SMILES
C12=NC=CN1C=CC=C2Br
CAS DataBase Reference
850349-02-9
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Safety

WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
750980
Product name
8-Bromoimidazo[1,2-a]pyridine
Purity
96%
Packaging
500mg
Price
$91.3
Updated
2023/01/07
TRC
Product number
B684493
Product name
8-Bromo-imidazo[1,2-a]pyridine
Packaging
250mg
Price
$55
Updated
2021/12/16
Matrix Scientific
Product number
055417
Product name
8-Bromoimidazo[1,2-a]pyridine
Purity
95%
Packaging
500mg
Price
$42
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-9-N5
Product name
8-Bromoimidazo[1,2-a]pyridine
Packaging
250mg
Price
$26
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB54448
Product name
8-Bromo-imidazo[1,2-a]pyridine
Packaging
1g
Price
$181.5
Updated
2021/12/16
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8-BROMO-IMIDAZO[1,2-A]PYRIDINE Chemical Properties,Usage,Production

Synthesis

107-20-0

13534-99-1

850349-02-9

The general procedure for the synthesis of 8-bromo-imidazo[1,2-A]pyridine from chloroacetaldehyde and 2-amino-3-bromopyridine was as follows: 2-amino-3-bromopyridine (5.00 g, 28.9 mmol) was dissolved in ethanol (100 mL), and sodium bicarbonate (3.64 g, 43.3 mmol) and 2-chloroacetaldehyde (7.1 mL, 43 mmol) were added sequentially. The reaction mixture was heated under reflux conditions with stirring for 4 hours. Upon completion of the reaction, the mixture was allowed to cool to room temperature and the solvent was subsequently removed by evaporation under reduced pressure. Water was added to the residue and extracted with ethyl acetate. The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (eluent ratio: n-hexane/ethyl acetate=70:30→40:60) to afford the target compound 8-bromoimidazo[1,2-a]pyridine (5.71 g, quantitative yield).

References

[1] Patent: EP3351533, 2018, A1. Location in patent: Paragraph 0524
[2] Patent: JP2018/145180, 2018, A. Location in patent: Paragraph 0490
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 21, p. 9089 - 9106,18
[4] Patent: WO2016/206101, 2016, A1. Location in patent: Page/Page column 84

8-BROMO-IMIDAZO[1,2-A]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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8-BROMO-IMIDAZO[1,2-A]PYRIDINE Suppliers

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View Lastest Price from 8-BROMO-IMIDAZO[1,2-A]PYRIDINE manufacturers

Henan Fengda Chemical Co., Ltd
Product
8-BROMO-IMIDAZO[1,2-A]PYRIDINE 850349-02-9
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-26

850349-02-9, 8-BROMO-IMIDAZO[1,2-A]PYRIDINERelated Search:

IMidazo[1,2-a]pyridine-3-carboxaldehyde, 8-broMo- 8-Bromoimidazo[1,2-a]pyrazine 8-bromoquinazoline-2,4(1H,3H)-dione IMidazo[1,2-a]pyridine-2-carboxaldehyde, 8-broMo- 8-bromoimidazo[1,2-a]pyridine-2-carboxylic acid IMidazo[1,2-a]pyridine-2-carboxylic acid, 8-broMo-, ethyl ester 8-BROMO-IMIDAZO[1,2-A]PYRIDINE 6-bromoH-imidazo[1,2-a]pyridine-2-carboxylic acid 6-BROMO-IMIDAZO[1,2-A]PYRIDIN-8-AMINE methyl 3-bromoH-imidazo[1,2-a]pyridine-6-carboxylate 5-BROMO-IMIDAZO[1,2-A]PYRIDINE methyl 3-bromoH-imidazo[1,2-a]pyridine-7-carboxylate ethyl 3-bromoH-imidazo[1,2-a]pyridine-5-carboxylate 3-BROMOIMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID 6-Bromoimidazo[1,2-a]pyridine 3-Bromoimidazo[1,5-a]pyridine-1-carboxylic acid Ethyl 6-chloroimidazo[1,2-a]pyridine-2-carboxylate 3-BROMOIMIDAZO[1,2-A]PYRIDINE

  • 8-BROMO-IMIDAZO[1,2-A]PYRIDINE
  • IMidazo[1,2-a]pyridine,8-broMo-
  • 8-broMoH-iMidazo[1,2-a]pyridine
  • 8-Bromoimidazo[1,2-a]pyridine,97%
  • 8-BROMO-IMIDAZO[1,2-A]PYRIDINE ISO 9001：2015 REACH
  • 8-Bromoimidazo[1,2-<i>a</i>]pyridine
  • 850349-02-9
  • Heterocycle-Pyridine series
  • Intermeidates
  • Alkenyl
  • Building Blocks
  • Chemical Synthesis
  • Halogenated Hydrocarbons
  • New Products for Chemical Synthesis
  • Organic Building Blocks