E3 ligase Ligand 14

Product Name: E3 ligase Ligand 14
CAS No.: 2241489-43-8
Chemical Name: E3 ligase Ligand 14
Synonyms: CST 530, Phenol;E3 ligase Ligand 14;tert-butyl N-[(1S)-1-{[(1S)-1-cyclohexyl-2-[(2S,4S)-4-(3-hydroxyphenoxy)-2-{[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}pyrrolidin-1-yl]-2-oxoethyl]carbamoyl}ethyl]-N-methylcarbamate;tert-Butyl ((S)-1-(((S)-1-Cyclohexyl-2-((2S,4S)-4-(3-hydroxyphenoxy)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
CBNumber: CB18054707
Molecular Formula: C38H52N4O7
Formula Weight: 676.84
MOL File: Mol file

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E3 ligase Ligand 14 Property

Boiling point:: 899.5±65.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
pka: 9.55±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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E3 ligase Ligand 14 Chemical Properties,Usage,Production

Uses

E3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

IC 50

IAP

References

[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168

E3 ligase Ligand 14 Preparation Products And Raw materials

Raw materials

Preparation Products

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E3 ligase Ligand 14 Suppliers

China 7 United States 1 Global 8

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

2241489-43-8, E3 ligase Ligand 14Related Search:

E3 ligase Ligand 18 E3 ligase Ligand 10 L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine E3 ligase Ligand-Linker Conjugates 38 Carbamic acid, N-[(1S)-2-[[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(3-hydroxybenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]methylamino]-1-methyl-2-oxoethyl]-N-methyl-, 1,1-dimethylethyl ester E3 ligase Ligand 12

E3 ligase Ligand 14

tert-Butyl ((S)-1-(((S)-1-Cyclohexyl-2-((2S,4S)-4-(3-hydroxyphenoxy)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate

tert-butyl N-[(1S)-1-{[(1S)-1-cyclohexyl-2-[(2S,4S)-4-(3-hydroxyphenoxy)-2-{[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}pyrrolidin-1-yl]-2-oxoethyl]carbamoyl}ethyl]-N-methylcarbamate

CST 530, Phenol

2241489-43-8