Orciprenaline
- Product Name
- Orciprenaline
- CAS No.
- 586-06-1
- Chemical Name
- Orciprenaline
- Synonyms
- orciprenaline;Orciprenaline USP/EP/BP;Epinephrine Impurity 43;Orciprenaline & Orciprenaline Sulfate;Isoprenaline Hydrochloride Impurity 28;Metaproterenol (base and/or unspecified salts);1-(3,5-dihydroxyphenyl)-2-isopropylaminoethanol;5-[1-hydroxy-2-(isopropylamino)ethyl]resorcinol;5-[2-(Isopropylamino)-1-hydroxyethyl]-1,3-benzenediol;3,5-Dihydroxy-a-[(isopropylamino)methyl]benzyl alcohol
- CBNumber
- CB1855195
- Molecular Formula
- C11H17NO3
- Formula Weight
- 211.26
- MOL File
- 586-06-1.mol
Orciprenaline Property
- Melting point:
- 100°
- Boiling point:
- 350.94°C (rough estimate)
- Density
- 1.1240 (rough estimate)
- refractive index
- 1.5718 (estimate)
- pka
- 9.11±0.10(Predicted)
- CAS DataBase Reference
- 586-06-1(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- API0006235
- Product name
- METAPROTERENOL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $253.05
- Updated
- 2021/12/16
Orciprenaline Chemical Properties,Usage,Production
Chemical Properties
Melting point: 100°C. Its sulfuric acid ([5874-97-5]) has a melting point of 202-203°C.
Originator
Alupent, Boehringer Ingelheim ,W. Germany ,1961
Uses
Bronchodilator.
Definition
ChEBI: Metaproterenol is a member of phenylethanolamines.
Manufacturing Process
In an initial operation, 3,5-diacetoxyacetophenone was reacted first with
bromine and then with isopropylamine to give 1-(3,5-dihydroxyphenyl)-2-
isopropylaminoethanone.
59 g of 1-(3,5-dihydroxy-phenyl)-2-isopropylaminoethanone (free base) were
dissolved in 590 cc of methanol, and the solution was hydrogenated in the
presence of about 80 g Raney nickel at room temperature and under a
pressure of 5 atm. Hydrogen absorption was terminated after a few minutes.
The catalyst was separated by vacuum filtration, and the filtrate, an ethanolic
solution of 1-(3,5-dihydroxyphenyl)-1-hydroxy-2-isopropylaminoethane, was
admixed with the calculated amount of an alcoholic 20% sulfuric acid solution.
A crystalline precipitate formed which was filtered off and washed with
alcohol. For purification, the product was dissolved in water and the solution
was filtered through iron-free charcoal.
Thereafter, the filtrate was evaporated to dryness in vacuo and the residue
was taken up in alcohol. The crystalline precipitate which separated out after
some standing was separated by vacuum filtration and washed with alcohol.
After recrystallization from 90% alcohol, 61 g (83.2% of theory) of 1-(3,5-
dihydroxyphenyl)-1-hydroxy-2-isopropylamino-ethane sulfate, MP 202° to
203°C, was obtained.
Therapeutic Function
Bronchodilator
Clinical Use
Metaproterenol was the first β- sympathomimetic drug with metabolic stability to achieve wide clinical use.
Orciprenaline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Orciprenaline manufacturers
- Product
- Orciprenaline 586-06-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-05-28
- Product
- Orciprenaline 586-06-1
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04