(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride

Product Name: (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
CAS No.: 1062580-52-2
Chemical Name: (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
Synonyms: (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride;TOF30;Tofacitinib-1;Tofatinib Impurity 5;Tofacitinib interMediate A;Tofacitinib intermediate 3;piperidin-3-amine dihydrochL;Tofacitinib Impurity 123 DiHCl;Azilsartan medoxomil impurity351;Tofacitinib Impurity 5 Dihydrochloride
CBNumber: CB21011155
Molecular Formula: C14H23ClN2
Formula Weight: 254.8
MOL File: Mol file

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(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Property

Melting point:: 249～251℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1/C14H22N2.ClH/c1-12-8-9-16(11-14(12)15-2)10-13-6-4-3-5-7-13;/h3-7,12,14-15H,8-11H2,1-2H3;1H/t12-,14+;/s3
InChIKey: FVRZQLQXDPJADE-WLZBWWFYNA-N
SMILES: C(C1C=CC=CC=1)N1CC[C@@H](C)[C@@H](NC)C1.Cl |&1:10,12,r|

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D480190
Product name: (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamineDihydrochloride
Packaging: 10g
Price: $235
Updated: 2021/12/16

AK Scientific

Product number: 1409AA
Product name: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-aminedihydrochloride
Packaging: 1g
Price: $72
Updated: 2021/12/16

Synthonix

Product number: P15037
Product name: 3-Piperidinamine,N,4-dimethyl-1-(phenylmethyl)-,hydrochloride(1:2),(3R,4R)-
Purity: 95+%
Packaging: 10g
Price: $80
Updated: 2021/12/16

Apolloscientific

Product number: OR54340
Product name: cis-1-Benzyl-4-methyl-3-(methylamino)piperidine dihydrochloride
Purity: 95+%
Packaging: 10g
Price: $149
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-5-2Q
Product name: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-aminedihydrochloride
Purity: 97.0%
Packaging: 250mg
Price: $190
Updated: 2021/12/16

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(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Chemical Properties,Usage,Production

Uses

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Uses

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride is a related compound of Tofacitinib (T528000). (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used to prepare janus kinase 1 selective inhibitor.

Synthesis

TiCl4(0.2g, 1mmol) and NEt3(0.15 g, 1.5 mmol) were added to toluene, and then add 1-benzyl-4-methyl-3-ketone piperidine (20.3 g, 100 mmol) at 35 ℃. The methylamine solution is added to the reaction solution (9.32 g, 120 mmol) and reaction for 4 h, followed by adding NaBH (OAC) 3 (0.32 g, 1.5 mmol) and glacial acetic acid 2 ml. After the reaction is complete, add saturated salt water to wash the reaction mixture. (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride was obtained after further purification.

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Suppliers

China 345 India 9 United Kingdom 3 United States 15 Global 372

Apollo Scientific Ltd.

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Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
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Sinbond Industiral Co., Ltd.

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Email: cici1124@gmail.com
Country: United Kingdom
ProdList: 248
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Leancare Ltd.

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Email: enquiry@leancare.co.uk
Country: United Kingdom
ProdList: 6446
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View Lastest Price from (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride 1062580-52-2
Price: US $30.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-05-17

Shanghai Joiny Pharmaceutical Co.,LTD

Product: (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride 1062580-52-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-12-05

Shaanxi Dideu New Materials Co. Ltd

Product: (3R,4R)-1-Benzyl-N,4-diMethylpiperidin-3-aMine dihydrochloride 1062580-52-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2024-11-14

1062580-52-2, (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochlorideRelated Search:

(1-Benzyl-4-Methyl-1,2,5,6-tetrahydropyridin-3-yl)carbaMic acid Methyl ester Methyl (1-benzyl-4-Methylpiperidin-3-yl)carbaMate 13-Deoxyepirubicin 3-((3R,4S)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile 3-METHOXYCARBONYLAMINO-4-METHYLPYRIDINE 1-[2-(2-methoxyphenoxy)ethylamino]-3-(9-methylcarbazol-4-yl)oxypropan-2-ol:hydrochloride Methyl (4-Methylpiperidin-3-yl)carbaMate 3-((3S,4R)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile 3-PiperidinaMine, 1-acetyl-N,4-diMethyl-N-1H-pyrrolo[2,3-d]pyriMidin-4-yl-, (3R,4R)- (9CI) 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE Tofacitinib citrate 3-bis(4-Methylbenzoyloxy)succinate)

CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE)

cis-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride

cis-1-Benzyl-4-methyl-3-(methylamino)piperidine dihydrochloride 95+%

cis-1-Benzyl-N3,4-dimethylpiperidin-3-amine dihydrochloride

(3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE

(3R,4R)-1-benzyl-N,4-diMethylpiperidin-3-aMine BIS-(HYDROCHLORIDE)

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride

3-PiperidinaMine, N,4-diMethyl-1-(phenylMethyl)-, hydrochloride (1:2), (3R,4R)-

(3R,4R)-N,4-DiMethyl-1-(phenylMethyl)-3-piperidi

(3R,4R)- Cis-1-benzyl-4-Methyl-3-(MethylaMino)piperidine

Tofacitinib interMediate A

(3R,4R)- cis-1-Benzyl-4-Methyl-3-(MethylaMino)piperidine dihydrochloride

(3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORID

3-Piperidinamine, N,4-dimethyl-1-(phenylmethyl)-, dihydrochloride, (3R,4R)-

Tofacitinib intermediate 3

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine HCl

(3R,4R)-(1-Benzyl-4-methyl-piperidin-3-yl)-methyl-amine dihydrochloride

(3R,4R)-1-Benzyl-3-(methylamino)-4-methylpiperidine Dihydrochloride

TOF30

Tofacitinib-1

Cis 1-benzyl-4-methyl-3-methylamino-piperidine hydrochloride

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine, hydrochloride (1:2)

piperidin-3-amine dihydrochL

(3R,?4R)?-N,?4-?Dimethyl-?1-?(phenylmethyl)?-3-?piperidinamine Dihydrochloride

Cis-n-benzyl-3-methylamino-4-methyl-piperidine bis-(, HCl )

(3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINEDITYDROCHLORIDE

(3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE 2HCL

Tofacitinib Impurity 5 Dihydrochloride

N-((3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydro...

Azilsartan medoxomil impurity351

(3R,4R)-N, 4-dimethyl-1 -(phenylmethyl) -3-piperidamine hydrochloride

Tofatinib Impurity 5

(3R,4R)-N,4-Dimethy1-(phenylmethyl)-3-piperidinamine hydrochloride

CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE) Tofacitinib （Int.）

Tofacitinib Impurity 123 DiHCl

(3R,4R)-N,4-Dimethyl-1-(benzyl)-3-piperidinamine 2HCl

(3R,4R)-1-Benzyl-N,4-dimethyl-3-piperidinamine dihydrochloride

1062580-52-2

C14H22N22HCl

1