ZOTAROLIMUS

ChemicalBook > CAS DataBase List > ZOTAROLIMUS

Product Name: ZOTAROLIMUS
CAS No.: 221877-54-9
Chemical Name: ZOTAROLIMUS
Synonyms: CS-1162;ABT 578;Resolute;A 179578;ZOTAROLIMUS;Unii-H4gxr80ize;ZotaroliMus API;Zotarolimus, >ZotaroliMus, >90%;ZotaroliMus(ABT-578)
CBNumber: CB21011766
Molecular Formula: C52H79N5O12
Formula Weight: 966.21
MOL File: 221877-54-9.mol

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ZOTAROLIMUS Property

Melting point:: 100-105°C
Boiling point:: 1016.2±75.0 °C(Predicted)
Density: 1.25
storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility: DMSO, Methanol (Slightly)
form: Solid
pka: 10.40±0.70(Predicted)
color: White to Pale Yellow

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Safety

HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29246
Product name: Zotarolimus
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 29246
Product name: Zotarolimus
Packaging: 25mg
Price: $343
Updated: 2024/03/01

Cayman Chemical

Product number: 29246
Product name: Zotarolimus
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29246
Product name: Zotarolimus
Packaging: 10mg
Price: $169
Updated: 2024/03/01

TRC

Product number: Z700800
Product name: Zotarolimus,>90%
Packaging: 10mg
Price: $145
Updated: 2021/12/16

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ZOTAROLIMUS Chemical Properties,Usage,Production

Description

Zotarolimus is a macrocyclic lactone immunosuppressant and a derivative of rapamycin . It binds to FKBP prolyl isomerase 1A (FKBP12; IC₅₀ = 2.57 nM) and inhibits proliferation of human peripheral blood mononuclear cells (PBMCs), rat splenocytes, and human coronary artery smooth muscle cells (IC₅₀s = 7, 1,337, and 0.8 nM, respectively). Zotarolimus has immunosuppressive activity in a one-way mixed lymphocyte reaction using human or rat lymphocytes (IC₅₀s = 1.2 and 1,465 nM, respectively). It also reduces symptom severity in a rat model of experimental autoimmune encephalomyelitis (EAE; ED₅₀ = 1.17 mg/kg per day) and delays cardiac allograft rejection in rats (ED₅₀ = 3.71 mg/kg per day). Zotarolimus inhibits neointimal formation and reduces stenosis in pig coronary arteries when applied at 10 μg/mm to stainless steel balloon expandable stents with phosphorylcholine in a model of restenosis. Formulations containing zotarolimus have been used in drug-eluting stents in the prevention of restenosis following stent placement.

Chemical Properties

Pale Yellow Solid

Uses

Zotarolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by preparation of the 42-triflate ester, followed by displacement with tetrazole and purification of the two isomeric products. This structural change affords a less bioavailable product, a preferred profile for some applications. Like all tacrolimus analogues, zotarolimus binds to a receptor protein (FKBP12). The complex then binds to preventing it from interacting with target proteins. Zotarolimus is extensively cited in the literature with over 200 citations.

Uses

A tetrazole-containing Rapamycin analog as immunomodulator and useful in the treatment of restenosis and immune and autoimmune diseases.

Definition

ChEBI: Zotarolimus is a macrolide and a lactam.

ZOTAROLIMUS Preparation Products And Raw materials

Raw materials

Preparation Products

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221877-54-9, ZOTAROLIMUSRelated Search:

AZD 3759 (2R)-1-{4-[(1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)propan-2-ol Zonisamide Z-NLE-OH ZM 336372 ZM 39923 HYDROCHLORIDE Z-NVA-OH Z-N-Methyl-D-valine Z-ORN(BOC)-OH ZPCK Tepotinib Saracatinib Dasatinib Trametinib Epothilone B Ruxolitinib ZOSUQUIDAR TRIHYSROCHLORIDE Rapamycin

ZOTAROLIMUS

(42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin

A 179578

ABT 578

ABT-578;A-179578;ABT578;A179578;ABT 578;A 179578

CS-1162

Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-

Unii-H4gxr80ize

ZotaroliMus, >90%

42-(1-Tetrazolyl)rapamycin

Resolute

ZotaroliMus API

42-deoxy-42-(1H-tetrazol-1-yl)-(42S)-Rapamycin

(42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin Zotarolimus(ABT-578) A 179578 Resolute

Zotarolimus A 179578

ZotaroliMus(ABT-578)

Zotarolimus, &gt

ZOTAROLIMUS USP/EP/BP

ZOTAROLIMUS Impurities

221877-54-9

C52H79N5O12

Inhibitors

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals