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Polygalacic acid

Product Name
Polygalacic acid
CAS No.
22338-71-2
Chemical Name
Polygalacic acid
Synonyms
Polygalacic;Polygalacicaci;Polygalacic acid;Virgaureagenin G;Polygalacic acid, >=98%;Virgaureagenin G,Polygalacic acid;(4R)-2β,3β,16α,23-Tetrahydroxyolean-12-en-28-oic acid;Polygalacic acid, 98%, from Polygala tenuifolia Willd.;(2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid;Olean-12-en-28-oicacid, 2,3,16,23-tetrahydroxy-, (2β,3β,4,16)-
CBNumber
CB21040708
Molecular Formula
C30H48O6
Formula Weight
504.7
MOL File
22338-71-2.mol
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Polygalacic acid Property

Melting point:
300-305 °C (sublm)
Boiling point:
638.1±55.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
pka
4.41±0.70(Predicted)
color 
White to off-white
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Safety

HS Code 
29163990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Usbiological
Product number
300805
Product name
Polygalacic acid
Packaging
20mg
Price
$490
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0005843
Product name
(2B,3B,4A,16A)-2,3,16,23-TETRAHYDROXYOLEAN-12-EN-28-OIC ACID
Purity
95.00%
Packaging
5MG
Price
$503.58
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
74064
Product name
Polygalacicacid
Purity
98%
Packaging
20mg
Price
$533
Updated
2021/12/16
Biorbyt Ltd
Product number
orb105678
Product name
Polygalacic acid
Purity
>98%,Standard References Grade
Packaging
20mg
Price
$569.5
Updated
2021/12/16
Biorbyt Ltd
Product number
orb594205
Product name
Virgaureagenin G
Packaging
5mg
Price
$596.7
Updated
2021/12/16
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Polygalacic acid Chemical Properties,Usage,Production

Uses

Polygalacic acid can be used to calm the nerves, eliminate phlegm, reduce swelling, etc. It is mostly used clinically to treat bronchitis, induce labor, and induce labor.

Biological Activity

Polygalacic acid is a triterpenoid tetrahydroxy acid isolated from Polygala paenea L.. It (0-100μM; 24h) can significantly reduce the mRNA expression of MMP-3, MMP-9, MMP-13 and COX-2, and the expression of these factors can be significantly increased by IL-1β in a dose-dependent manner .

in vitro

Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a In a dose-dependent manner. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid.

RT-PCR

Cell Line: Chondrocyte cells
Concentration: 50 μM; 100 μM
Incubation Time: 24 hours
Result: Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression.

Western Blot Analysis

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Cell Line: Chondrocyte cells
Concentration: 50 μM; 100 μM
Incubation Time : 6 hours
Result: Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes.

Polygalacic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Polygalacic acid Suppliers

CHEMICAL LAND21
Tel
--
Fax
--
Email
sales21@chemicalland21.com
Country
South Korea
ProdList
6303
Advantage
74
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View Lastest Price from Polygalacic acid manufacturers

Career Henan Chemical Co
Product
Polygalacic acid 22338-71-2
Price
US $1.00/kg
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-24

22338-71-2, Polygalacic acidRelated Search:


  • Polygalacic acid
  • Polygalacic
  • (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
  • Olean-12-en-28-oicacid, 2,3,16,23-tetrahydroxy-, (2β,3β,4,16)-
  • Virgaureagenin G
  • (4R)-2β,3β,16α,23-Tetrahydroxyolean-12-en-28-oic acid
  • Polygalacic acid or (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
  • Polygalacic acid (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
  • Polygalacic acid, >=98%
  • (4AR,5R,6aS,6bR,9R,10R,11S,12aR,12bR,14bR)-5,10,11-trihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12
  • Polygalacic acid, 98%, from Polygala tenuifolia Willd.
  • Polygalacicaci
  • Olean-12-en-28-oic acid, 2,3,16,23-tetrahydroxy-, (2β,3β,4α,16α)-
  • Virgaureagenin G,Polygalacic acid
  • 22338-71-2
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract