2-Chloro-6-cyanobenzothiazole
- Product Name
- 2-Chloro-6-cyanobenzothiazole
- CAS No.
- 80945-83-1
- Chemical Name
- 2-Chloro-6-cyanobenzothiazole
- Synonyms
- 2-Chloro-6-cyanobenzothiazole;2-Chloro-benzothiazole-6- carbonitrile;6-Benzothiazolecarbonitrile, 2-chloro-;2-chlorobenzo[d]thiazole-6-carbonitrile;2-chloro-1,3-benzothiazole-6-carbonitrile;6-Benzothiazolecarbonitrile,2-chloro-(9CI)
- CBNumber
- CB21072857
- Molecular Formula
- C8H3ClN2S
- Formula Weight
- 194.64
- MOL File
- 80945-83-1.mol
2-Chloro-6-cyanobenzothiazole Property
- Boiling point:
- 336.6±15.0 °C(Predicted)
- Density
- 1.51
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.07±0.10(Predicted)
- Appearance
- Yellow to brown Solid
Safety
- HS Code
- 2934208090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C427628
- Product name
- 2-Chlorobenzothiazole-6-carbonitrile
- Packaging
- 25mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC150768
- Product name
- 2-Chlorobenzothiazole-6-carbonitrile
- Packaging
- 100mg
- Price
- $81
- Updated
- 2021/12/16
- Product number
- FC150768
- Product name
- 2-Chlorobenzothiazole-6-carbonitrile
- Packaging
- 250mg
- Price
- $162.5
- Updated
- 2021/12/16
- Product number
- 7H70-5-1F
- Product name
- 2-Chloro-1,3-benzothiazole-6-carbonitrile
- Purity
- 95%
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FC150768
- Product name
- 2-Chlorobenzothiazole-6-carbonitrile
- Packaging
- 500mg
- Price
- $280
- Updated
- 2021/12/16
2-Chloro-6-cyanobenzothiazole Chemical Properties,Usage,Production
Uses
2-Chlorobenzothiazole-6-carbonitrile
Synthesis
19759-66-1
80945-83-1
Step A: Synthesis of 2-chlorobenzothiazole-6-carbonitrile; To a mixture of 4-aminobenzyl cyanide (23.6 g, 0.2 mol) and ammonium thiocyanate (30.4 g, 0.4 mol) was added glacial acetic acid (600 mL) and the resulting solution was cooled to 13.5 °C in an ice bath. The mixture of bromine and glacial acetic acid was slowly added dropwise. The reaction mixture was continuously stirred at 13.5 °C for 1 hour and then filtered. The filter cake was washed with glacial acetic acid (6 x 100 mL) and subsequently stirred in hot water (1000 mL). After filtration, the pH of the filtrate was adjusted with saturated sodium carbonate solution to 7. The precipitate was separated and dried to give 19.5 g (56% yield) of 2-aminobenzothiazole-6-carbonitrile. A mixture of concentrated hydrochloric acid (113 mL) and water (52 mL) was heated to 90 °C and 2-aminobenzothiazole-6-carbonitrile (19 g, 0.108 mol) was added. The mixture was cooled to -5 °C in an ice bath and a solution of sodium nitrite (7.72 g, 0.112 mol) in water (20 mL) was added slowly dropwise, controlling the reaction temperature below 0 °C. After the dropwise addition was completed, stirring was continued for 0.5 h. Subsequently, a solution of copper(II) chloride (16 g) in water (108 mL) was added slowly dropwise. After completion of the dropwise addition, stir for 10 minutes and remove the ice bath. Stirring was continued for 2 h. The mixture was cooled to room temperature and filtered. The solid was washed to neutrality with water and dried to give 12.8 g (61% yield) of 2-chlorobenzothiazole-6-carbonitrile.1H-NMR data: δ 8.14 (s, 1H), 8.03 (d, 1H), 7.75 (d, 1H).
References
[1] Patent: WO2007/110364, 2007, A1. Location in patent: Page/Page column 38
[2] Patent: WO2017/103614, 2017, A1. Location in patent: Page/Page column 81
2-Chloro-6-cyanobenzothiazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-6-cyanobenzothiazole manufacturers
- Product
- 2-Chloro-6-cyanobenzothiazole 80945-83-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-18