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2-Chloro-6-cyanobenzothiazole

Product Name
2-Chloro-6-cyanobenzothiazole
CAS No.
80945-83-1
Chemical Name
2-Chloro-6-cyanobenzothiazole
Synonyms
2-Chloro-6-cyanobenzothiazole;2-Chloro-benzothiazole-6- carbonitrile;6-Benzothiazolecarbonitrile, 2-chloro-;2-chlorobenzo[d]thiazole-6-carbonitrile;2-chloro-1,3-benzothiazole-6-carbonitrile;6-Benzothiazolecarbonitrile,2-chloro-(9CI)
CBNumber
CB21072857
Molecular Formula
C8H3ClN2S
Formula Weight
194.64
MOL File
80945-83-1.mol
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2-Chloro-6-cyanobenzothiazole Property

Boiling point:
336.6±15.0 °C(Predicted)
Density 
1.51
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-2.07±0.10(Predicted)
Appearance
Yellow to brown Solid
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Safety

HS Code 
2934208090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C427628
Product name
2-Chlorobenzothiazole-6-carbonitrile
Packaging
25mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC150768
Product name
2-Chlorobenzothiazole-6-carbonitrile
Packaging
100mg
Price
$81
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC150768
Product name
2-Chlorobenzothiazole-6-carbonitrile
Packaging
250mg
Price
$162.5
Updated
2021/12/16
SynQuest Laboratories
Product number
7H70-5-1F
Product name
2-Chloro-1,3-benzothiazole-6-carbonitrile
Purity
95%
Packaging
250mg
Price
$175
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC150768
Product name
2-Chlorobenzothiazole-6-carbonitrile
Packaging
500mg
Price
$280
Updated
2021/12/16
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2-Chloro-6-cyanobenzothiazole Chemical Properties,Usage,Production

Uses

2-Chlorobenzothiazole-6-carbonitrile

Synthesis

19759-66-1

80945-83-1

Step A: Synthesis of 2-chlorobenzothiazole-6-carbonitrile; To a mixture of 4-aminobenzyl cyanide (23.6 g, 0.2 mol) and ammonium thiocyanate (30.4 g, 0.4 mol) was added glacial acetic acid (600 mL) and the resulting solution was cooled to 13.5 °C in an ice bath. The mixture of bromine and glacial acetic acid was slowly added dropwise. The reaction mixture was continuously stirred at 13.5 °C for 1 hour and then filtered. The filter cake was washed with glacial acetic acid (6 x 100 mL) and subsequently stirred in hot water (1000 mL). After filtration, the pH of the filtrate was adjusted with saturated sodium carbonate solution to 7. The precipitate was separated and dried to give 19.5 g (56% yield) of 2-aminobenzothiazole-6-carbonitrile. A mixture of concentrated hydrochloric acid (113 mL) and water (52 mL) was heated to 90 °C and 2-aminobenzothiazole-6-carbonitrile (19 g, 0.108 mol) was added. The mixture was cooled to -5 °C in an ice bath and a solution of sodium nitrite (7.72 g, 0.112 mol) in water (20 mL) was added slowly dropwise, controlling the reaction temperature below 0 °C. After the dropwise addition was completed, stirring was continued for 0.5 h. Subsequently, a solution of copper(II) chloride (16 g) in water (108 mL) was added slowly dropwise. After completion of the dropwise addition, stir for 10 minutes and remove the ice bath. Stirring was continued for 2 h. The mixture was cooled to room temperature and filtered. The solid was washed to neutrality with water and dried to give 12.8 g (61% yield) of 2-chlorobenzothiazole-6-carbonitrile.1H-NMR data: δ 8.14 (s, 1H), 8.03 (d, 1H), 7.75 (d, 1H).

References

[1] Patent: WO2007/110364, 2007, A1. Location in patent: Page/Page column 38
[2] Patent: WO2017/103614, 2017, A1. Location in patent: Page/Page column 81

2-Chloro-6-cyanobenzothiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-6-cyanobenzothiazole Suppliers

China 73 Europe 1 India 2 United Kingdom 1 United States 9 Global 86
CHEMSTEP
Tel
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Fax
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Email
info@chemstep.com
Country
Europe
ProdList
6143
Advantage
51
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View Lastest Price from 2-Chloro-6-cyanobenzothiazole manufacturers

Career Henan Chemical Co
Product
2-Chloro-6-cyanobenzothiazole 80945-83-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KGS
Release date
2019-12-18

80945-83-1, 2-Chloro-6-cyanobenzothiazoleRelated Search:

6-CHLORO-2-HYDROXYPYRAZINE METHYL 2-CHLORO-6-METHOXYPYRIDINE-4-CARBOXYLATE 2-CHLORO-6-METHOXY-4-PYRIDINECARBOXALDEHYDE 2-CHLORO-6-METHOXYBENZONITRILE 2-Chlorobenzothiazole Ethyl isocyanoacetate 2-Mercaptobenzothiazole Sodium cyanoborohydride Epichlorohydrin Benzothiazole 2,2'-Dithiobis(benzothiazole) ETHYL 2-CYANOACRYLATE Methylene dithiocyanate Chloroacetic acid Difluorochloromethane 2-Chloro-6-methylbenzothiazole 6-BENZOTHIAZOLECARBONITRILE 2-Chloro-6-cyanobenzothiazole

  • 2-Chloro-benzothiazole-6- carbonitrile
  • 6-Benzothiazolecarbonitrile,2-chloro-(9CI)
  • 2-chloro-1,3-benzothiazole-6-carbonitrile
  • 6-Benzothiazolecarbonitrile, 2-chloro-
  • 2-chlorobenzo[d]thiazole-6-carbonitrile
  • 2-Chloro-6-cyanobenzothiazole
  • 80945-83-1
  • BENZOTHIAZOLE