ChemicalBook > CAS DataBase List > BOC-HYP-OL

BOC-HYP-OL

Product Name: BOC-HYP-OL
CAS No.: 61478-26-0
Chemical Name: BOC-HYP-OL
Synonyms: TERT-BUTYL (2S,4R)-4-HYDROXY-2-(HYDROXYMETHYL)PYRROLIDINE-1-CARBOXYLATE; 61478-26-0;(2S,4R)-tert-butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate;BOC-HYP-OL;Boc-Hydroxyprolinol;BOC-HYP-OL USP/EP/BP;BOC-PRO(4-HYDROXY)-OL;Boc-L-hydroxyprolinol;Boc-trans-4-hydroxy-L;(-)-N-BOC-L-4-HYDROXYPROLINOL
CBNumber: CB2110415
Molecular Formula: C10H19NO4
Formula Weight: 217.26
MOL File: 61478-26-0.mol

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BOC-HYP-OL Property

Melting point:: 81-86 °C (lit.)
alpha: -47o (C=1 IN CHLOROFORM)
Boiling point:: 340.3±27.0 °C(Predicted)
Density: 1.190±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 14.57±0.40(Predicted)
color: White
optical activity: [α]20/D 47°, c = 1 in chloroform
Sensitive: Air Sensitive
InChI: InChI=1S/C10H19NO4/c1-10(2,3)15-9(14)11-5-8(13)4-7(11)6-12/h7-8,12-13H,4-6H2,1-3H3/t7-,8+/m0/s1
InChIKey: UFJNFQNQLMGUTQ-JGVFFNPUSA-N
SMILES: N1(C(OC(C)(C)C)=O)C[C@H](O)C[C@H]1CO
CAS DataBase Reference: 61478-26-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 546992
Product name: Boc-trans-4-hydroxy-L-prolinol
Purity: 96%
Packaging: 1g
Price: $62.3
Updated: 2023/06/20

TCI Chemical

Product number: B3662
Product name: (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine
Purity: >96.0%(GC)
Packaging: 1g
Price: $43
Updated: 2025/07/31

TCI Chemical

Product number: B3662
Product name: (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine
Purity: >96.0%(GC)
Packaging: 5g
Price: $163
Updated: 2025/07/31

TRC

Product number: H942835
Product name: (2S,4R)-4-Hydroxy-2-(hydroxymethyl)-1-pyrrolidinecarboxylicAcidtert-ButylEster
Packaging: 100mg
Price: $50
Updated: 2021/12/16

Chem-Impex

Product number: 41653
Product name: (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine,96%(GC)
Purity: 96%(GC)
Packaging: 1G
Price: $59.36
Updated: 2021/12/16

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BOC-HYP-OL Chemical Properties,Usage,Production

Chemical Properties

Viscous Oil

Uses

BOC-HYP-OL is a useful reactant used in the preparation of 4-purinylpyrrolidine nucleosides, kinase inhibitors and antibacterial agents.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

74844-91-0

61478-26-0

Under argon protection, 1-tert-butyl 2-methyl-(2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate (5.0 g, 20.41 mmol) was dissolved in THF (100 mL), cooled to -16 °C and stirred. LiAlH4 (1 M solution of THF, 21 mL, 21 mmol) was added slowly and dropwise over 5 min and precipitate formation was observed in the reaction. THF (50 mL) was subsequently added to destroy the precipitate. The reaction mixture was gradually warmed to 0 °C with stirring for 3.5 hours. Upon completion of the reaction, the reaction was quenched with EtOAc (5 mL) and stirring was continued for 30 minutes. Then, an excess of Rochelle's salt solution (100 mL) was carefully added, and the mixture was warmed to room temperature and stirred for an additional 1 hour. The mixture was extracted twice with CH2Cl2 (100 mL), the organic phases were combined, dried with MgSO4, filtered and concentrated under reduced pressure to remove the solvent. The product was purified by column chromatography (eluent: 10% MeOH/CH2Cl2) to give Intermediate 19 in quantitative yield.1H NMR (300 MHz, DMSO-d6) δ: 4.82 (br s, 1H), 4.64 (br d, J = 5.5 Hz, 1H), 4.20 (sxt, J = 4.2 Hz, 1H), 3.75 (br s , 1H), 3.16-3.50 (m, 4H), 1.85-2.02 (m, 1H), 1.80 (br s, 1H), 1.39 (s, 9H).

References

[1] Patent: WO2017/29521, 2017, A1. Location in patent: Page/Page column 37
[2] Journal of Medicinal Chemistry, 1991, vol. 34, # 9, p. 2787 - 2797
[3] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 1, p. 56 - 60
[4] Patent: US2014/256016, 2014, A1. Location in patent: Paragraph 0024; 0025
[5] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1989, vol. 28, # 1-11, p. 294 - 296

BOC-HYP-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-HYP-OL Suppliers

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View Lastest Price from BOC-HYP-OL manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: BOC-HYP-OL 61478-26-0
Price: US $60.00-500.00/g
Min. Order: 5g
Purity: 99%
Supply Ability: 50
Release date: 2024-07-10

Career Henan Chemical Co

Product: BOC-HYP-OL 61478-26-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 2kg
Release date: 2018-08-16

61478-26-0, BOC-HYP-OLRelated Search:

N-Boc-L-Phenylalaninol N-Boc-exo-3-aminotropane BOC-D-Methionine N-Boc-D-Phenylalaninol N-Boc-L-Homoserine BOC-D-ALPHA-T-BUTYLGLYCINE N-Boc-D-Valino Boc-Lys-OH (2S, 4R)-BOC-GAMMA-MSO-PROLINE METHYL ESTER N-Boc-cis-4-Hydroxy-L-proline BOC-HYP(BZL)-OH N-Boc-trans-4-tosyloxy-L-proline methyl ester N-Boc-cis-4-Hydroxy-L-proline methyl ester Boc-Hyp-OH N-Boc-trans-4-Hydroxy-L-proline methyl ester (2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-PHENOXY-2-PYRROLIDINECARBOXYLIC ACID BOC-HYP-OH DCHA (2S,4R)-BOC-4-PHENOXY-PYRROLIDINE-2-CARBOXYLIC ACID

TERT-BUTYL (2S,4R)-4-HYDROXY-2-(HYDROXYMETHYL)PYRROLIDINE-1-CARBOXYLATE

(-)-N-BOC-L-4-HYDROXYPROLINOL

N-BOC-TRANS-4-HYDROXY-L-PROLINOL

N-T-BUTOXYCARBONYL-TRANS-4-HYDROXY-L-PROLINOL

BOC-HYP-OL

BOC-PRO(4-HYDROXY)-OL

BOC-TRANS-4-HYDROXY-L-PROLINOL

1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2S,4R)-

1-BOC-TRANS-4-HYDROXY-L-PROLINOL

(2S,4R)-4-Hydroxy-2-hydroxymethyl-1-pyrrolidinecarboxylic acid tert-butyl ester

（2S,4R）-tert-butyl-4-hydroxy-2-（hydroxymethyl）carboxylat

(2S,4R)-tert-butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Boc-L-hydroxyprolinol

N-tert-Butoxycarbonyl-trans-4-hydroxy-L-prolinol

(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxyMethyl)pyrrolidine

(2S,4R)-tert-butyl 4-hydroxy-2-(hydroxyMethyl)pyrrolidine-1-carb

tert-Butyl 2-hydroxy-2-((2S,4R)-4-hydroxypyrrolidin-2-yl)acetate

(2S,4R)-1-Boc-4-hydroxy-2-(hydroxymethyl)pyrrolidine

(2S,4R)-4-Hydroxy-2-(hydroxymethyl)pyrrolidine, N-BOC protected

trans-4-Hydroxy-L-prolinol, N-BOC protected, tert-Butyl (2S,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

1-Pyrrolidinecarboxylicacid, 4-hydroxy-2-(hydroxymethyl)-

61478-26-0

(2S,4R)-tert-butyl-4-hydroxy-2-(hydroxymethyl)carboxylate

(4R)-1-Boc-4-hydroxy-L-prolinol

(2S,4R)-N-Boc-4-hydroxy-2-(hydroxymethyl)pyrrolidine

(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-(hydroxymethyl)pyrrolidine &gt

Boc-trans-4-hydroxy-L

(2S,4R)-1-BOC-4-HYDROXY-2-(HYDROXYMETHYL)PYRROLINE

(2S,4R)-4-Hydroxy-2-(hydroxymethyl)pyrrolidine

BOC-HYP-OL USP/EP/BP

Boc-Hydroxyprolinol

(2S,4R)-N-Boc-2-hydroxymethyl-4-hydroxy-prrolidine

1,1-Dimethylethyl (2S,4R)-4-hydroxy-2-(hydroxymethyl)-1-pyrrolidinecarboxylate

(2S,4R)-N-Boc-2-hydroxymethyl-4-hydroxy-pyrrolidine

Boc-<i>trans</i>-4-hydroxy-<sc>L</sc>-prolinol

61478-26-0

Amino Alcohols

Amino Acid Derivatives

Peptide Synthesis

Specialty Synthesis

Amino Acid Derivatives

Amino Alcohols

Peptide Synthesis