Overview Absorption and metabolism of ALA Biological effects of ALA Adverse reactions References
ChemicalBook > CAS DataBase List > Linolenic acid

Linolenic acid

Overview Absorption and metabolism of ALA Biological effects of ALA Adverse reactions References
Product Name
Linolenic acid
CAS No.
463-40-1
Chemical Name
Linolenic acid
Synonyms
α-Linolenic acid;ALPHA-LINOLENIC ACID;9,12,15-OCTADECATRIENOIC ACID;linolenic;a-Linolenic acid;OCTADECA-9Z,12Z,15Z-TRIENOIC ACID;(Z,Z,Z)-9,12,15-Octadecatrienoic acid;ALPHA-LNN;A-linolenic;α-linolenic acid (ALA)
CBNumber
CB2112323
Molecular Formula
C18H30O2
Formula Weight
278.43
MOL File
463-40-1.mol
More
Less

Linolenic acid Property

Melting point:
-11 °C(lit.)
Boiling point:
230-232 °C1 mm Hg(lit.)
Density 
0.914 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.480(lit.)
FEMA 
3380 | 9,12-OCTADECADIENOIC ACID (48%) AND 9,12,15-OCTADECATRIENOIC ACID (52%)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly)
pka
4.78±0.10(Predicted)
form 
Liquid
color 
Clear colorless to light yellow
Specific Gravity
0.91
Odor
faint fatty
Water Solubility 
INSOLUBLE
Merck 
14,5506
BRN 
1727693
InChIKey
DTOSIQBPPRVQHS-PDBXOOCHSA-N
LogP
6.52
CAS DataBase Reference
463-40-1(CAS DataBase Reference)
NIST Chemistry Reference
9,12,15-Octadecatrienoic acid, (Z,Z,Z)-(463-40-1)
EPA Substance Registry System
Linolenic acid (463-40-1)
More
Less

Safety

Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
RIDADR 
UN1170 - class 3 - PG 2 - Ethanol
WGK Germany 
1
F 
8-10-23
HS Code 
29161500
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L-039
Product name
alpha-Linolenic acid
Purity
1.0?mg/mL in ethanol, certified reference material, Cerilliant?
Packaging
1mL
Price
$147
Updated
2024/03/01
Sigma-Aldrich
Product number
62170
Product name
Linolenic acid
Purity
~70% (GC)
Packaging
10ml
Price
$189
Updated
2024/03/01
Sigma-Aldrich
Product number
62170
Product name
Linolenic acid
Purity
~70% (GC)
Packaging
50mL
Price
$719
Updated
2024/03/01
Sigma-Aldrich
Product number
62160
Product name
Linolenic acid
Purity
analytical standard
Packaging
1ml
Price
$146
Updated
2024/03/01
Sigma-Aldrich
Product number
62160
Product name
Linolenic acid
Purity
analytical standard
Packaging
5ml
Price
$567
Updated
2024/03/01
More
Less

Linolenic acid Chemical Properties,Usage,Production

Overview

The alpha-linolenic acid (ALA 18:3w,463-40-1) an omega-3 (n-3) fatty acid, is an essential fatty acid (EFA) that cannot be synthesized by the body and therefore must be supplied by dietary sources. ALA is abundant in certain plant foods including walnuts, rapeseed (canola), several legumes, flaxseed, and green leafy vegetables.[1] ALA is the precursor of three important longer-chain n-3 fatty acids, eicosapentaenoic acid (EPA 20:5w3), docosapentaenoic acid (DPAw3 22:5w3), and docosahexaenoic acid (DHA 22:6w3), which have vital roles in brain development and function, cardiovascular health, and inflammatory response.[2-5] Omega-3 fatty acids are incorporated into the membrane lipid bilayer in virtually all body cells and affect membrane composition, eicosanoid biosynthesis, cell signaling cascades, and gene expression[6].

Absorption and metabolism of ALA

As a rule, dietary fats are absorbed very efficiently from the digestive tract, and ALA is no exception. Burdge 16 recently reported that absorption levels of ALA are 96% or more. There are several possible metabolic fates for ALA that enters the bloodstream. The body can store the fatty acids in adipose tissue, use them for acetyl-CoA or energy production through b-oxidation, synthesize other non-essential saturated or monounsaturated fatty acids (MUFA), or convert them to longer-chain n-3 polyunsaturated fatty acids (PUFA) in the liver. The activity of the desaturation/elongation pathway is of unique importance as it is responsible for the synthesis of EPA and DHA. What is presently understood concerning conversion of ALA to EPA, DPAw3, and DHA is that the first step in the pathway, addition of a fourth double bond by D 6 desaturase, is considered to be the rate-limiting step. This is followed by elongation (addition of two carbon atoms) and an additional desaturation by the enzyme D 5 desaturase, with the product being 20:5n-3 or EPA. Several possibilities have been suggested for the precise pathway for production of DHA (22:6n-3) from EPA in humans. It was assumed that the conversion of DPAw3 to DHA would be carried out by a D4 desaturase but, thus far, little or no D4 desaturase has been found. Sprecher[8] has provided evidence for elongation of 22:5w3 to 24:5w3,which is then desaturated by the rate limiting D 6 desaturase to yield a 24:6w3. Two carbons are then cleaved in the peroxisomes to yield DHA that is then exported to the reticuloendothelial system. Thus, the insertion of the last double bond in DHA production in human metabolism may be rather indirect and somewhat inefficient. There are some doubts as to the validity of the Sprecher shunt, but it provides a possible explanation for the small proportions of DHA produced and the build up of DPAw3, despite ample ALA available in foods and in body tissues.
Alpha-linolenic acid is partially converted to EPA in humans (8–20%), while conversion rates of ALA to DHA are estimated at 0.5–9%[9, 10]. The sex difference in metabolism is well known. Studies in women of reproductive age showed a substantially greater (2.5-fold) rate of conversion of ALA to EPA than that measured in healthy men. Thus, the ability to produce long-chain metabolites is gender dependent. It appears that women have a lower partitioning of ALA to b-oxidation, leaving more of it available for conversion to EPA[7, 11]. Other possible explanations include a direct effect of estrogen on conversion rates[7, 12]. Gender differences have also been observed in the conversion rates of ALA to DHA. In males it is estimated that only 0.5–4% of ALA is converted to DHA while in females the rates are thought to be as high as 9%[11, 12]. It is hypothesized that demands for DHA by the fetus during pregnancy may stimulate female physiology to more readily synthesize this fatty acid.

Biological effects of ALA

Cardio-protective effect
There are several studies that strongly indicate that ALA may indeed be important in maintaining heart health. Because ALA is a precursor of the longer chained n-3 fatty acids, it contributes to the body pools of EPA and DHA that have been associated with improved vascular tone, heart rate, serum lipid levels, platelet function, inflammatory responses, arrhythmia, growth rates of atherosclerotic plaques, and blood pressure[13-15]. Most of these beneficial effects have also been associated specifically with ALA consumption.
Interest in the role of ALA in the prevention of heart disease arose following the publication of the Lyon Heart Study carried out in France[16] This study provided the first evidence that ALA consumption may play an important role in reduction of heart disease. In this secondary prevention trial, which included 608 patients with known CHD, participants in the intervention group were encouraged to follow the Mediterranean diet and were supplied with canola margarine rich in ALA. At 27-month follow-up, a 73% reduction in cardiovascular events was observed along with a 70% decrease in overall mortality. ALA intake in the intervention group was three times higher than that in the control subjects. Although it appears that ALA may have contributed to the improvement in cardiac health, there were numerous independent variables in the study, which makes it impossible to isolate the effects of ALA per se. Mozaffarian[13] reviewed the findings from observational studies that evaluated the relationship between ALA intake and risk of CHD or mortality. In most studies, particularly those in the American population, an inverse association between ALA consumption and incidence of CHD was found. For example, the Cardiovascular Health Study[17] which included a prospective cohort of close to 6000 older men and women, found that each one standard deviation increase in plasma phospholipid ALA levels (a biomarker of ALA intake) was associated with a 52% decrease in risk for fatal CHD. In The Nurses Health Study[18, 19] over 75,000 women were followed using dietary intake records to assess ALA consumption. ALA intake was associated with a significantly lower risk of sudden cardiac death. These results help support the hypothesis that ALA may have antiarrhythmic properties.
Inflammation
In a previous study, men suffering from dyslipidemia were provided a high-ALA diet (canola oil 15 ml/day) or a safflower oil control diet[20]. After 3 months, in individuals consuming the canola oil diet, systemic inflammation was significantly reduced, as measured by C-reactive protein, serum amyloid A, and interleukin-6. Additional evidence that ALA consumption affects biomarkers of inflammation and endothelial activation was observed in a crosssectional study of 727 women in the Nurses Health Study[21]. An inverse relationship was observed between ALA intake and plasma concentrations of C-reactive protein, IL-6, E-selectin, soluble intercellular cell adhesion molecule 1, and soluble vascular cell adhesion molecule 1.
This provides support for the role of ALA as an antiinflammatory agent that also lowers endothelial activation. Ferrucci et al[22] also reported that higher levels of ALA in the blood were associated with lower levels of inflammatory biomarkers. His study included 1123 individuals, aged 20–98 years. Fatty acids in fasting plasma were analyzed in relation to numerous inflammatory markers. Decreased levels of C-reactive protein and IL-1ra levels were associated with higher plasma ALA levels.
Zhao et al[23] have shown that dietary ALA elicits antiinflammatory effects by inhibiting IL-6, IL-1beta, and TNF-alpha production in peripheral blood mononuclear cells cultured from hypercholesterolemic individuals exposed to a diet high in ALA (6.5% of energy). Thus, consumption of ALA may provide protection against heart disease and other inflammatory diseases by reduction of inflammatory cytokines.
Other health benefits
Attention deficit hyperactivity disorder: A recent study by Joshi et al.[24] reported a significant improvement in the symptoms of ADHD in children that had received flax oil and Vitamin C supplements. Neuroprotection: Lauritzen et al.[25] reported that ALA prevented neuronal death in an animal model of transient global ischemia; it also protected animals treated with kainate against seizures and hippocampal lesions. An additional study reported neuroprotective effects in rat models of spinal cord ischemia leading to paraplegia[26]. ALA treatment preserved neurological function and animals sustained only mild-to-moderate injury. This suggests that ALA can induce protection against ischemia in spinal injury, preventing necrosis and apoptosis of motor neurons.
Autoimmune diseases: Work in animal models by Reiffen et al[27] suggests that the addition of flaxseed oil (70% ALA) to the diet may attenuate the severity of systemic lupus erythematosus (SLE or lupus). SLE mice fed flaxseed exhibited lower titers of antibodies to DNA and to cardiolipin and less severe kidney damage than mice fed other diets, including fish oil.

Adverse reactions

However, concern has arisen from one metaanalysis that reported an increased incidence of prostate cancer risk in men with high intake or high blood levels of ALA (combined relative risk 1.70; 95% CI 1.12–2.58).
The data presented was heterogeneous and the authors themselves stated it is uncertain if the results present a genuine effect. The results have yet to be confirmed. More recent reviews did not confirm or refute this possible deleterious effect of ALA.

References

  1. Gebauer SK, Psota TL, Harris WS, Kris-Etherton PM. Am J Clin Nutr. 2006;83(Suppl):S1526–S1535.
  2. Holman RT. J Nutr. 1998; 128(Suppl): S427–S433.
  3. Das UN. Essential fatty acids – a review. Curr Pharm Biotechnol. 2006;7:467–482.
  4. Leaf A. Omega-3 fatty acids and prevention of arrhythmias. Curr Opin Lipidol. 2007;18:31–34.
  5. Wang C, Chung M, Balk E, et al.  Am J Clin Nutr. 2006;83:5–17.
  6. Shahidi F, Miraliakbari H. Omega-3 fatty acids in health and disease: part 2–health effects of omega-3 fatty acids in autoimmune diseases, mental health, and gene expression. J Med Food. 2005;8: 133–148.
  7. Burdge GC. Metabolism of alpha-linolenic acid in humans. Prostaglandins Leukot Essent Fatty Acids. 2006;75:161– 168.
  8. Sprecher H. The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2002;67:79–83.
  9. Burdge GC. Curr Opin Clin Nutr Metab Care. 2004;7:137–144.
  10. DeFilippis AP, Sperling LS. Understanding omega-3s. Am Heart J. 2006;151:564–570.
  11. Burdge GC, Calder PC. Reprod Nutr Dev. 2005;45:581–589.
  12. Giltay EJ, Gooren LJ, Toorians AW, Katan MB, Zock PL. Am J Clin Nutr. 2004;80:1167–1174.
  13. Mozaffarian D. Altern Ther Health Med. 2005;11:24–30.
  14. Mori TA. Omega-3 fatty acids and hypertension in humans. Clin Exp Pharmacol Physiol. 2006;33:842–846.
  15. Robinson JG, Stone NJ. Antiatherosclerotic and antithrombotic effects of omega-3 fatty acids. Am J Cardiol. 2006;98(4A):39i–49i.
  16. de Lorgeril M, Renaud S, Mamelle N, et al. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet. 1994;343:1454–1459.
  17. Lemaitre RN, King IB, Mozaffarian D, et al. n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study. Am J Clin Nutr. 2003;77:319–325.
  18. Hu FB, Stampfer MJ, Manson JE, et al. Am J Clin Nutr. 1999;70:1001–1008.
  19. Albert CM, Oh K, Whang W, et al. Dietary alpha-linolenic acid intake and risk of sudden cardiac death and coronary heart disease. Circulation. 2005;112:3232–3238.
  20. Rallidis LS, Paschos G, Liakos GK, Velissaridou AH, Anastasiadis G, Zampelas A. Atherosclerosis. 2003;167:237–242.
  21. Lopez-Garcia E, SchulzeMB, Manson JE, et al. J Nutr. 2004;134: 1806–1811.
  22. Ferrucci L, Cherubini A, Bandinelli S, et al. Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers. J Clin Endocrinol Metab. 2006;91:439–446.
  23. Zhao G, Etherton TD, Martin KR, Gillies PJ, West SG, Kris-Etherton PM. Am J Clin Nutr. 2007;85:385–391.
  24. Joshi K, Lad S, Kale M, et al. Supple mentation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD). Prostaglandins Leukot Essent Fatty Acids. 2006;74:17–21.
  25. Lauritzen I, Blondeau N, Heurteaux C, et al. EMBO J. 2000;19: 1784–1793.
  26. Lang-Lazdunski L, Blondeau N, Jarretou G, et al. J Vasc Surg. 2003;38:564–575.
  27. Reifen R, Blank M, Afek A, et al. Lupus. 1998;7:192–197.

Description

Linolenic acid (LA), also known as Alpha-linolenic acid (ALA), is an omega-3 essential fatty acid with a wide range of biological activities such as cardiovascular protection, anticancer, neuroprotection, anti-osteoporosis, anti-inflammatory, and antioxidant.LA is mainly sourced from plants, such as nuts and seeds, and is used for the endogenous synthesis of LC omega-6 fatty acids. It is used medicinally as a nutritional supplement and to treat dietary deficiencies or imbalances.

Chemical Properties

clear light yellow to yellow liquid

Occurrence

linolenic acid occurs as the glyceride in many seed fats. It is an essential fatty acid in the diet.

Uses

Linolenic acid has been used:

  • to assess the total antioxidative activity of serum and bacteria
  • in palleroni chamber assay
  • to prepare free fatty acid mixture

Uses

An essential fatty acid. Occurs as the glyceride in most drying oils. Nutrient.

Uses

linolenic acid is also known as alpha-linolenic acid; omega-3. An essential fatty acid found in most drying oils. It is slightly irritating to the mucous membranes. It may be used in a cosmetic preparation for any of the following broad uses: anti-static, cleansing, emollient, skin-conditioning, and surfactant properties.

Definition

linolenic acid: A liquid polyunsaturatedfatty acid with three doublebonds in its structure:CH3CH2CH:CHCH2CH:CHCH2CH:CH-(CH2)7COOH. It occurs in certainplant oils, e.g. linseed and soya-beanoil, and in algae. It is one of the essentialfatty acids.

Definition

ChEBI: Alpha-linolenic acid is a linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect. It has a role as a micronutrient, a nutraceutical and a mouse metabolite. It is an omega-3 fatty acid and a linolenic acid. It is a conjugate acid of an alpha-linolenate and a (9Z,12Z,15Z)-octadeca-9,12,15-trienoate.

benefits

Linolenic acid (LA) is an essential fatty acid with anti-inflammatory, anti-bacterial, anti-atherosclerotic and anti-cancer activities, and has a variety of health benefits, including: lowering high blood pressure and cholesterol, lowering the risk of heart disease, maintaining the membrane fluidity of the epidermal transdermal water barrier, improving the barrier function of the skin, decreasing inflammation, regulating sebum secretion, moisturising the scalp, promoting hair growth and prevents hair breakage. It also has a whitening effect on over-pigmented skin.

General Description

Linolenic acid is a clear colorless liquid. (NTP, 1992)

Air & Water Reactions

Oxidizes in air to form peroxides, which spontaneously ignite. Insoluble in water. Sensitive to heat and moisture.

Reactivity Profile

Linolenic acid is incompatible with bases, oxidizing agents and reducing agents. Also incompatible with peroxides, oxygen and water.

Fire Hazard

Linolenic acid is probably combustible.

Biochem/physiol Actions

An ω-3 fatty acid that serves as a precursor to eicosapentaenoic acid (EPA) but not docosahexaenoic acid. Conversion is greater in women than men, and conversely, β-oxidation metabolism is greater in men than women.

Carcinogenicity

Narisawa et al. found that diets high in perilla oil (with high a-linolenic acid but also high levels of linoleic acid) lowered the risk of colon cancer in a rat model initiated with the carcinogen N-methyl-Nnitrosourea. Okuno found a suppressive effect on diethylnitrosamine- induced heptaocarcinogenesis in male Fischer 344 rats treated with either safflower (high in linoleic acid) or perilla oil (high in both linoleic and α-linolenic acids). Kitano et al. found that 10% α-linolenic acid did not promote urninary bladder cancer initiated in rats with N-butyl-N-(4-hydrocybutyl)nitrosamine. Mice fed a-linolenic acid at 5–10% of the diet had increased mammary gland ductular cell proliferation.

Linolenic acid Preparation Products And Raw materials

Raw materials

unsaturated fatty acid Crude oil Lipase GAMMA-LINOLENIC ACID METHYL ESTER Naphthalene Eucalyptus Citriodara Oil LINOLENIC ACID ETHYL ESTER gamma-Linolenic acid ANION STANDARD - NITRATE Acetyl chloride Evening primrose oil Linoleic acid Dark chrome yellow capsule Flaxseed oil Oleic acid SPIRULINA POWDER FATTY ACID METHYL ESTER MIX C8-C22 D-GALACTOSE 1-[2-(2-AZIDOETHOXY)ETHOXYETHYL]-2,3,4,6-TETRA-O-ACETATE

Preparation Products

More
Less

Linolenic acid Suppliers

Americas 1 Australia 1 Belgium 2 Canada 3 China 336 Europe 3 France 2 Germany 6 India 11 Japan 3 Poland 1 South Korea 1 Spain 1 Switzerland 3 United Kingdom 10 United States 42 USA 1 Global 427
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
Will Health Technology (Wuhan) Co., Ltd
Tel
18186610332 18186610332
Email
pengying@wellnj.com
Country
China
ProdList
151
Advantage
58
Jiangxi yuanshangcao flavor Co., Ltd.
Tel
0796-828-2352 18979604038
Email
1182634205@qq.com
Country
China
ProdList
295
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
021-51613915-820 13611835272
Fax
021 51613951
Email
mmwang@sunwaypharm.cn
Country
China
ProdList
9734
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2872
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Ruji Biology Technology Co., Ltd.
Tel
+86-21-65211385-8001 36031160
Fax
+86-21-65211385-8004
Email
sales@shruji.com
Country
China
ProdList
3224
Advantage
55
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Nanjing Dulai Biotechnology Co., Ltd.
Tel
025-84699383-8003 18013301590
Fax
025-84699383-8003
Email
njduly@126.com
Country
China
ProdList
971
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Cheng Du Pufeide Biotechnology Co., Ltd.
Tel
028-82610909 13388174823
Fax
8171-1798
Email
scglp@glp-china.com
Country
China
ProdList
1064
Advantage
58
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791,13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3921
Advantage
50
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9978
Advantage
55
TianJin Alta Scientific Co., Ltd.
Tel
022-65378550-8551
Fax
+86-022-2532-9655
Email
contact@altascientific.com
Country
China
ProdList
2773
Advantage
58
Yichang Zhongyitai Trading Co., Ltd.
Tel
0717-6449896 13886658719
Fax
0717-6558598
Email
root@zhongyitai.com
Country
China
ProdList
1977
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7887
Advantage
56
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Shanghai Aspire Biological Technology Co., Ltd.
Tel
021-61317773
Fax
021-61486878
Email
sales@aspirebio.com
Country
China
ProdList
2880
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
7295
Advantage
60
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11481
Advantage
59
Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.
Tel
027-59420981,18702770802
Fax
027-83322098
Country
China
ProdList
1975
Advantage
50
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9958
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
More
Less

View Lastest Price from Linolenic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Linolenic acid 463-40-1
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
65%,70%,80%
Supply Ability
10kg/month
Release date
2021-05-27
BINBO BIOLOGICAL CO.,LTD
Product
Alpha Linolenic Acid Powder（ALA） 463-40-1
Price
US $0.00/kg
Min. Order
1kg
Purity
40% 60% 95% 98%
Supply Ability
3000 kg
Release date
2024-04-17
Hebei Weibang Biotechnology Co., Ltd
Product
Linolenic acid 463-40-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-28

463-40-1, Linolenic acidRelated Search:

VIGABATRIN Folic acid Docosahexaenoic Acid EPA Linoleic acid Arachidonic acid Undecenoic acid Stearic acid Ethyl 2-(Chlorosulfonyl)acetate Hyaluronic acid Citric acid Diethyl isopropylidenemalonate α-L-Idopyranose Pentaacetate Ascoric Acid Isobutyl nitrite Nicotinic acid ISOPROPYL NITRITE Phosphorous acid

  • OCTADECA-9Z,12Z,15Z-TRIENOIC ACID
  • (Z,Z,Z)-9,12,15-Octadecatrienoic acid
  • 9,12,15-OCTADECATRIENIC ACID
  • 9,12,15-OCTADECATRIENOIC ACID
  • 9Z,12Z,15Z-OCTADECATRIENOIC ACID
  • ALPHA-LINOLENIC ACID
  • ALPHA-LNN
  • ALL CIS-9,12,15-OCTADECATRIENOIC ACID
  • ALFA-LINOLENIC ACID
  • LINOLENIC ACID
  • CIS,CIS,CIS-9,12,15-OCTADECATRIENOIC ACID
  • DELTA 9 CIS 12 CIS 15 CIS OCTADECATRIENOIC ACID
  • C18:3 (ALL CIS-9,12,15) ACID
  • LINOLENSAEURE NATUERLICH*
  • LINOLENIC ACID, STANDARD FOR GC
  • alpha-Linolenicacid70%
  • Linolenic acid, tech., remainder linoleic acid, 90%
  • A-linolenic
  • 9,12,15-Octadecatrienoic acid, (9Z,12Z,15Z)-
  • LINOLENICACID(FREE)
  • LINOLENICACID,PRACTICAL
  • a-Linolenic acid
  • ALPHA-LINOLENICACIDS
  • ALPHA-LINOLENATE
  • CIS-9,12,15-ALPHA-LINOLENICACID
  • CIS-ALPHA-LINOLENICACID
  • Linolensure
  • 9,12,15-all-cis-Octadecatrienoic acid
  • LINOLENIC ACID WITH GC
  • α-Lnn, cis,cis,cis-9,12,15-Octadecatrienoic acid
  • γ-lenoleinic acid(GLA)
  • γ-Liliolenic acid
  • (Z,Z,Z)-Octadeca-9,12,15-trienoic acid
  • Linolenic acid, 90%, remainder linoleic acid, tech.
  • Linolenic acid, 98.5%
  • 12,15-Octadecatrienoicacid,(Z,Z,Z)-9
  • 15-octadecatrienoicacid,(z,z,z)-12
  • acidelinolenique
  • cis,cis,cis-octadeca-9,12,15-trienoicacid
  • cis-9,cis-12,cis-15-octadecatrienoicacid
  • Industrene 120
  • linolenic
  • Linolenic acid,α-Lnn, cis,cis,cis-9,12,15-Octadecatrienoic acid
  • α-Lnn
  • all cis-Delta-9,12,15-octadecatrienoate
  • (9Z,12Z,15Z)-9,12,15-Octadecatrienoic acid
  • 18:3(n-3)
  • 18:3n-3
  • Linolenic acid,70%, remainder isomers
  • Linolenic acid,90%,tech., remainder linoleicacid
  • Linolenic acid,99%
  • 9-cis,12-cis,15-cis-Octadecatrienoic acid
  • α-linolenic acid (ALA)
  • 8,11,14-Heptadecatriene-1-carboxylic acid
  • (all-Z)-9,12,15-Octadecatrienoic Acid
  • (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid
  • LINOLENIC ACID(ALA)(SG)
  • Linolenic acid, 99% 1GR