ChemicalBook > CAS DataBase List > 4-Chloro-2-methoxyphenylboronic acid

4-Chloro-2-methoxyphenylboronic acid

Product Name
4-Chloro-2-methoxyphenylboronic acid
CAS No.
762287-57-0
Chemical Name
4-Chloro-2-methoxyphenylboronic acid
Synonyms
2-Borono-5-chloroanisole;4-Chloro-2-methoxyphenylboronic;oro-2-methoxybenzeneboronic acid;4-chloro-2-Methoxybenzaldehyde acid;4-Chloro-2-methoxybenzeneboronicaci;4-Chloro-2-methoxyphenylboronic aci;4-CHLORO-2-METHOXYPHENYLBORONIC ACID;2-Methoxy-4-chlorobenzeneboronic acid;4-CHLORO-2-METHOXYBENZENEBORONIC ACID;B-(4-Chloro-2-methoxyphenyl)boronic acid
CBNumber
CB2120832
Molecular Formula
C7H8BClO3
Formula Weight
186.4
MOL File
762287-57-0.mol
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4-Chloro-2-methoxyphenylboronic acid Property

Melting point:
128-134°C
Boiling point:
345.4±52.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
8.42±0.58(Predicted)
color 
White to Almost white
InChI
InChI=1S/C7H8BClO3/c1-12-7-4-5(9)2-3-6(7)8(10)11/h2-4,10-11H,1H3
InChIKey
NZRRMTBNTSBIFH-UHFFFAOYSA-N
SMILES
B(C1=CC=C(Cl)C=C1OC)(O)O
CAS DataBase Reference
762287-57-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
Hazard Note 
Irritant
HS Code 
2931900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C3248
Product name
4-Chloro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging
1g
Price
$183
Updated
2025/07/31
TCI Chemical
Product number
C3248
Product name
4-Chloro-2-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging
200mg
Price
$60
Updated
2025/07/31
TRC
Product number
C596833
Product name
4-Chloro-2-methoxyphenylboronicAcid
Packaging
50mg
Price
$60
Updated
2021/12/16
Synthonix
Product number
C2214
Product name
(4-Chloro-2-methoxyphenyl)boronicacid
Purity
97%
Packaging
25g
Price
$570
Updated
2021/12/16
Matrix Scientific
Product number
126621
Product name
(4-Chloro-2-methoxyphenyl)boronicacid
Purity
>97%
Packaging
25g
Price
$935
Updated
2021/12/16
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4-Chloro-2-methoxyphenylboronic acid Chemical Properties,Usage,Production

Uses

suzuki reaction

Synthesis

174913-09-8

121-43-7

762287-57-0

General procedure for the synthesis of 4-chloro-2-methoxyphenylboronic acid: preparation of intermediate I-1. 22.1 g (100 mmol) of 2-bromo-5-chloroanisole was dissolved in 500 mL of tetrahydrofuran (THF) and stirred for 10 min at -78 °C and protected by nitrogen (N2). Subsequently, 44 mL of a 2.5 M solution of n-butyllithium (n-BuLi) was slowly added through a dropping funnel and stirring was continued for 30 minutes. Next, 10.4 g (110 mmol) of trimethyl borate was slowly added dropwise, and after completion of the dropwise addition, the reaction mixture was warmed to room temperature and stirred for 3 hours. After completion of the reaction, the reaction was quenched with 300 mL of 1 M hydrochloric acid (HCl) and the organic layer was extracted three times with diethyl ether and washed with water. The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography to afford 13.61 g of Intermediate I-1 (73 mmol, 73% yield). The resulting compound was characterized by mass spectrometry (MS/FAB): theoretical value of [M+H]+ (C7H8BClO3) 186.40, measured value 186.47.

References

[1] Organic Letters, 2016, vol. 18, # 15, p. 3630 - 3633
[2] Patent: US2016/190448, 2016, A1. Location in patent: Paragraph 0261; 0262; 0263
[3] Patent: US2016/190449, 2016, A1. Location in patent: Paragraph 0271; 0272

4-Chloro-2-methoxyphenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Chloro-2-methoxyphenylboronic acid manufacturers

Henan Fengda Chemical Co., Ltd
Product
4-Chloro-2-methoxyphenylboronic acid 762287-57-0
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-31
Chemwill Asia Co.,Ltd.
Product
4-Chloro-2-methoxyphenylboronic acid 762287-57-0 762287-57-0
Price
US $66.00/KG
Min. Order
1KG
Purity
99.50% IN STOCK
Supply Ability
20 MT per month
Release date
2019-09-03
Chemwill Asia Co.,Ltd.
Product
762287-57-0 4-Chloro-2-methoxybenzeneboronic acid 762287-57-0
Price
US $96.00/KG
Min. Order
1KG
Purity
99.50% IN STOCK
Supply Ability
33 MT per month
Release date
2019-09-03

762287-57-0, 4-Chloro-2-methoxyphenylboronic acidRelated Search:

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  • 4-CHLORO-2-METHOXYPHENYLBORONIC ACID
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  • 762287-57-0 4-Chloro-2-methoxybenzeneboronic acid
  • REF DUPL: 4-Chloro-2-methoxyphenylboronic acid
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  • oro-2-methoxybenzeneboronic acid
  • 4-Chloro-2-methoxybenzeneboronicaci
  • B-(4-Chloro-2-methoxyphenyl)boronic acid
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