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morpholin-3-one

Product Name
morpholin-3-one
CAS No.
109-11-5
Chemical Name
morpholin-3-one
Synonyms
3-MORPHOLINONE;3-Oxomorpholine;in-3-on;3-morpholone;JACS-109-11-5;Morpholin-3-on;MORPHOLIN-3-ONE;morpholine-3-one;3-Ketomorpholine;3-Morpholinone>
CBNumber
CB2121662
Molecular Formula
C4H7NO2
Formula Weight
101.1
MOL File
109-11-5.mol
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morpholin-3-one Property

Melting point:
103.0 to 107.0 °C
Boiling point:
142°C/7mmHg(lit.)
Density 
1.122±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
14.37±0.20(Predicted)
color 
White to Almost white
CAS DataBase Reference
109-11-5(CAS DataBase Reference)
EPA Substance Registry System
3-Morpholinone (109-11-5)
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Safety

Safety Statements 
24/25
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2788
Product name
3-Morpholinone
Purity
>98.0%(GC)
Packaging
5g
Price
$56
Updated
2024/03/01
TCI Chemical
Product number
M2788
Product name
3-Morpholinone
Purity
>98.0%(GC)
Packaging
25g
Price
$198
Updated
2024/03/01
TRC
Product number
M723840
Product name
3-Morpholinone
Packaging
10g
Price
$75
Updated
2021/12/16
TRC
Product number
M723840
Product name
3-Morpholinone
Packaging
1g
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
074514
Product name
Morpholin-3-one
Purity
95+%
Packaging
25g
Price
$48
Updated
2021/12/16
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morpholin-3-one Chemical Properties,Usage,Production

Description

3-ketomorpholine is also known as morpholin-3-one. It is useful pharmacological intermediate. Recent studies have shown that some morpholin-3-one derivatives could effectively cause cell cycle arrest at G1 phase, increase the levels of P53 and Fas, and induce A549 cell apoptosis in lung cancer. This indicates it might be a useful tool for elucidating the molecular mechanism of lung cancer cell apoptosis and might also be potential anti-cancer drugs. Some of its derivatives have been proven to be useful for the prevention and treatment of arteriosclerosis and hypertriglyceridemia.

Uses

3-Morpholinone is used as a reactant in the synthesis of 3-Morpholinone derivates. An example of this is 4-(4-Aminophenyl)-3-morpholinone, the key intermediate in the synthesis of Rivaroxaban (an anticoagulant).

References

He, Q., et al. "Novel morpholin-3-one derivatives induced apoptosis and elevated the level of P53 and Fas in A549 lung cancer cells." Bioorganic & Medicinal Chemistry 15.11(2007): 3889.
Murai, Hiromu, et al. "Morpholinone derivatives and method of use." US, US4237132. 1980.
Gonzalez-garcia, Maria Rosario, and Fernandez, Maria Carmen. "Morpholinyl derivatives useful as MOGAT-2 inhibitors." (2015).

morpholin-3-one Preparation Products And Raw materials

Raw materials

Sodium hydride Monoethanolamine Ethanol Toluene Methyl bromoacetate Ethyl acetate PETROLEUM ETHER

Preparation Products

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View Lastest Price from morpholin-3-one manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
morpholin-3-one 109-11-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
500kg/month
Release date
2021-12-13
Hebei Dangtong Import and export Co LTD
Product
morpholin-3-one 109-11-5
Price
US $40.00-36.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-06
Hebei Chuanghai Biotechnology Co,.LTD
Product
3-Morpholinone 109-11-5
Price
US $1.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-20

109-11-5, morpholin-3-oneRelated Search:

6-Hydroxy-2(1H)-3,4-dihydroquinolinone Tridemorph Moroxydine hydrochloride Dimethomorph Moroxydine Fenmetramide 3-Morpholinone, 4-phenyl- 6-[4-(Trifluoromethyl)phenyl]morpholin-3-one,6-(α,α,α-Trifluoro-p-tolyl)morpholin-3-one thiomorpholin-3-one R-5-PHENYL-MORPHOLIN-2-ONE 4-METHYLBENZO[B]MORPHOLIN-3-ONE 5,6-Diphenyl-2-morpholinone BENZO[B]MORPHOLIN-3-ONE 5-MORPHOLINO-2-NITROPHENOL 5-Phenyl-2-morpholinone 4-(4-NITROPHENYL)MORPHOLIN-3-ONE lateritin 4-T-BOC-(5S)-5-[(1S)-METHYLPROPYL]-MORPHOLIN-3-ONE

  • Morpholin-3-on
  • 3-Oxomorpholine
  • MORPHOLIN-3-ONE
  • morpholine-3-one
  • 3-morpholone
  • 3-MORPHOLINONE
  • 3-Ketomorpholine
  • Morpholin-3-one ,98%
  • in-3-on
  • JACS-109-11-5
  • 3-Morpholinone&gt
  • morpholin-3-one USP/EP/BP
  • 3-morpholone/ 3-Ketomorpholine
  • 3-KetomorpholineQ: What is 3-Ketomorpholine Q: What is the CAS Number of 3-Ketomorpholine Q: What is the storage condition of 3-Ketomorpholine
  • 3-Morpholinone (6CI, 7CI, 8CI, 9CI, ACI)
  • 3-Morpholin-4-ylne
  • 109-11-5
  • Heterocycles
  • Heterocycles series