ChemicalBook > CAS DataBase List > 5-BROMO-3-IODO-PYRIDIN-2-OL

5-BROMO-3-IODO-PYRIDIN-2-OL

Uses

Product Name: 5-BROMO-3-IODO-PYRIDIN-2-OL
CAS No.: 381233-75-6
Chemical Name: 5-BROMO-3-IODO-PYRIDIN-2-OL
Synonyms: 5-bromo-3-iodopyrazin-2-ol;5-Bromo-3-iodopyridine-2-ol;5-BroMo-3-iodopyridin-2(1H)-one;5-bromo-4-iodopyridin-2(1H)-one;5-BroMo-3-iodo-1H-pyridin-2-one;2-Hydroxy-3-iodo-5-bromopyridine;5-Bromo-2-hydroxy-3-iodopyridine;2(1H)-Pyridinone, 5-broMo-3-iodo-;5-Bromo-3-iodo-2-hydroxypyridine,97%;5-BroMo-3-iodo-2-hydroxypyridine, 97%
CBNumber: CB21229309
Molecular Formula: C5H3BrINO
Formula Weight: 299.89
MOL File: 381233-75-6.mol

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5-BROMO-3-IODO-PYRIDIN-2-OL Property

Melting point:: 226-227℃
Boiling point:: 307.9±42.0 °C(Predicted)
Density: 2.55±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 8.52±0.10(Predicted)
Appearance: Light yellow to yellow Solid
Sensitive: Light Sensitive
InChI: InChI=1S/C5H3BrINO/c6-3-1-4(7)5(9)8-2-3/h1-2H,(H,8,9)
InChIKey: WAUPPDAXWKLNNU-UHFFFAOYSA-N
SMILES: C1(=O)NC=C(Br)C=C1I
CAS DataBase Reference: 381233-75-6

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000304
Product name: 5-Bromo-3-iodo-pyridin-2-ol
Purity: Aldrich
Packaging: 1g
Price: $512
Updated: 2023/06/20

Matrix Scientific

Product number: 026130
Product name: 5-Bromo-3-iodo-pyridin-2-ol
Packaging: 500mg
Price: $20
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139959
Product name: 5-Bromo-3-iodopyridin-2(1H)-one
Packaging: 2g
Price: $66
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-S-13
Product name: 5-Bromo-2-hydroxy-3-iodopyridine
Packaging: 5G
Price: $77
Updated: 2021/12/16

AK Scientific

Product number: V5607
Product name: 5-Bromo-3-iodopyridin-2(1h)-one
Packaging: 10g
Price: $80
Updated: 2021/12/16

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5-BROMO-3-IODO-PYRIDIN-2-OL Chemical Properties,Usage,Production

Uses

5-BROMO-3-IODO-PYRIDIN-2-OL can be used as a pharmaceutical synthesis intermediate. It can be prepared by using 2-amino-5-bromopyridine as a reactant to prepare 2-amino-5-bromo-3-iodopyridine, followed by further diazotization; or it can be prepared by iodination using 5-bromo-2-hydroxypyridine as a reactant.

Synthesis

13466-38-1

381233-75-6

General procedure for the synthesis of 5-bromo-3-iodopyridin-2(1H)-one from 2-hydroxy-5-bromopyridine: 5-bromo-2-hydroxypyridine (2.5 g, 14.4 mmol), iodosuccinimide (4.7 g, 20.9 mmol), and acetonitrile (40 mL) were mixed, and the reaction was stirred for 20 min at 82 °C. After completion of the reaction, the mixture was cooled to room temperature and the solid was collected by filtration. The filter cake was recrystallized with ethyl acetate to afford the target product 5-bromo-2-hydroxy-3-iodopyridine (4.0 g) in 92.6% yield.

References

[1] Patent: CN108084186, 2018, A. Location in patent: Paragraph 0187-0188
[2] Synlett, 2003, # 11, p. 1678 - 1682
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 4, p. 1644 - 1668
[4] Patent: WO2015/132727, 2015, A1. Location in patent: Page/Page column 22; 28
[5] Heterocycles, 2002, vol. 57, # 1, p. 55 - 71

5-BROMO-3-IODO-PYRIDIN-2-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-3-IODO-PYRIDIN-2-OL Suppliers

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View Lastest Price from 5-BROMO-3-IODO-PYRIDIN-2-OL manufacturers

Career Henan Chemical Co

Product: 5-BROMO-3-IODO-PYRIDIN-2-OL 381233-75-6
Price: US $5.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

381233-75-6, 5-BROMO-3-IODO-PYRIDIN-2-OLRelated Search:

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5-Bromo-2-hydroxy-3-iodopyridine

2(1H)-Pyridinone, 5-broMo-3-iodo-

5-BroMo-3-iodo-1H-pyridin-2-one

5-BroMo-3-iodo-2-hydroxypyridine, 97%

5‐bromo‐3‐iodo‐1,2‐dihydropyridin‐2‐one

5-bromo-2-hydroxy-3-iodopyridine, 5-bromo-3-iodopyridin-2-ol

5-BroMo-3-iodopyridin-2(1H)-one

5-Bromo-2-hydroxy-3-iodopyridine 95+%

5-bromo-4-iodopyridin-2(1H)-one

2-Hydroxy-3-iodo-5-bromopyridine

5-Bromo-3-iodo-2-hydroxypyridine,97%

5-bromo-3-iodopyrazin-2-ol

5-Bromo-3-iodopyridine-2-ol

5-Bromo-3-iodo-pyridin-2-ol

381233-75-6