1-bromo-4-methoxy-naphthalene
- Product Name
- 1-bromo-4-methoxy-naphthalene
- CAS No.
- 5467-58-3
- Chemical Name
- 1-bromo-4-methoxy-naphthalene
- Synonyms
- NSC 25655;?1-Bromo-4-methoxynaphtaleme;4-Methoxy-1-broMonaphthalene;4-BroMo-1-Methoxynaphthalene;1-Methoxy-4-broMonaphthalene;1-bromo-4-methoxy-naphthalene;4-Bromo-1-naphthyl Methyl Ether;Naphthalene, 1-bromo-4-methoxy-
- CBNumber
- CB21255522
- Molecular Formula
- C11H9BrO
- Formula Weight
- 237.09
- MOL File
- 5467-58-3.mol
1-bromo-4-methoxy-naphthalene Property
- Melting point:
- 195-196 °C
- Boiling point:
- 181 °C(Press: 18 Torr)
- Density
- 1.447±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- Oil
- Appearance
- Yellow to brown Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B6147
- Product name
- 1-Bromo-4-methoxynaphthalene
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $59
- Updated
- 2025/07/31
- Product number
- B6147
- Product name
- 1-Bromo-4-methoxynaphthalene
- Purity
- min. 98.0 %
- Packaging
- 25G
- Price
- $194
- Updated
- 2025/07/31
- Product number
- B684785
- Product name
- 1-Bromo-4-methoxynaphthalene
- Packaging
- 250mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- J97372
- Product name
- 1-Bromo-4-methoxy-naphthalene
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- FB147728
- Product name
- 1-Bromo-4-methoxynaphthalene
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
1-bromo-4-methoxy-naphthalene Chemical Properties,Usage,Production
Chemical Properties
Oil
Uses
Synthetic intermediate.
Synthesis Reference(s)
The Journal of Organic Chemistry, 11, p. 399, 1946 DOI: 10.1021/jo01174a017
Synthesis
2216-69-5
5467-58-3
The general procedure for the synthesis of 1-bromo-4-methoxynaphthalene from 1-methoxynaphthalene was as follows: 1-methoxy-3,5-dimethylbenzene (100 mg, 0.73 mmol), N-bromosuccinimide (NBS, 260 mg, 1.46 mmol), and a stainless steel ball (5 mm in diameter) were placed in a 10 mL stainless steel milling jar. The ball milling reaction was carried out and the progress of the reaction was monitored by thin layer chromatography (TLC) and proton nuclear magnetic resonance (1H NMR). Upon completion of the reaction, the reaction mixture was transferred to 30 mL of ethyl acetate and cooled at 0 °C. The product was separated as a filtrate by filtration through filter paper and the spent succinimide was separated as a precipitate. The resulting filtrate was concentrated under vacuum to give 250 mg (yield: 85%) of 1-bromo-4-methoxynaphthalene as a colorless powder. To test the efficiency of the large-scale reaction, monobromination of 1-methoxy-3,5-dimethylbenzene on a scale of 1.3 g was also carried out with a reaction time of 1 h. The product was isolated in 87% yield. During the reaction, the grinding equipment was suspended and a small sample was removed from the reaction tank for TLC and 1H NMR analysis. Subsequently, the reaction was restarted and the time of this operation was not included in the total reaction time.
References
[1] Bulletin of the Chemical Society of Japan, 1989, vol. 62, # 2, p. 591 - 593
[2] Journal of Chemical Research - Part S, 2003, # 9, p. 597 - 598
[3] Synthetic Communications, 2004, vol. 34, # 12, p. 2143 - 2152
[4] Tetrahedron Letters, 2001, vol. 42, # 39, p. 6941 - 6942
[5] Angewandte Chemie - International Edition, 2018, vol. 57, # 39, p. 12869 - 12873
1-bromo-4-methoxy-naphthalene Preparation Products And Raw materials
Raw materials
Preparation Products
1-bromo-4-methoxy-naphthalene Suppliers
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View Lastest Price from 1-bromo-4-methoxy-naphthalene manufacturers
- Product
- 1-bromo-4-methoxy-naphthalene 5467-58-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 2000
- Release date
- 2025-04-18
- Product
- 1-bromo-4-methoxy-naphthalene 5467-58-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2023-03-07
- Product
- 1-bromo-4-methoxy-naphthalene 5467-58-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2023-03-08