ChemicalBook > CAS DataBase List > Ethyl 1-aminocyclopropanecarboxylate hydrochloride

Ethyl 1-aminocyclopropanecarboxylate hydrochloride

Product Name
Ethyl 1-aminocyclopropanecarboxylate hydrochloride
CAS No.
42303-42-4
Chemical Name
Ethyl 1-aminocyclopropanecarboxylate hydrochloride
Synonyms
Ethyl 1-aminocyclopropane-1-carboxylate hydrochloride;H-ACPC-OET hydrochloride;ACPC-OEt HCl;ACPC-OMe HCl;H-AC3C-OET HCL;H-ACPC-OET HCL;H-CAIB-OET HCL;H-(1)NHCPROPN-OET HCL;H-AC3C-OEt Hydrochloride;H-ACPC-OET HCL USP/EP/BP
CBNumber
CB2125837
Molecular Formula
C6H12ClNO2
Formula Weight
165.62
MOL File
42303-42-4.mol
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Ethyl 1-aminocyclopropanecarboxylate hydrochloride Property

Melting point:
gt. 110.0 and le 118.0 °C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Water Solubility 
Soluble in water
form 
Crystalline Powder
color 
White
CAS DataBase Reference
42303-42-4
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36-38-36/37-24/25-22-7/9-36/37/39
WGK Germany 
3
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
MNO000004
Product name
Ethyl 1-aminocyclopropanecarboxylate hydrochloride
Purity
Aldrich
Packaging
1g
Price
$42.8
Updated
2025/07/31
Sigma-Aldrich
Product number
728934
Product name
Ethyl 1-aminocyclopropanecarboxylate hydrochloride
Purity
97%
Packaging
1g
Price
$60.01
Updated
2025/07/31
TCI Chemical
Product number
E0937
Product name
Ethyl 1-Aminocyclopropanecarboxylate Hydrochloride
Purity
>98.0%(N)(T)
Packaging
1g
Price
$31
Updated
2025/07/31
TCI Chemical
Product number
E0937
Product name
Ethyl 1-Aminocyclopropanecarboxylate Hydrochloride
Purity
>98.0%(N)(T)
Packaging
5g
Price
$113
Updated
2025/07/31
TRC
Product number
E899835
Product name
Ethyl 1-Aminocyclopropanecarboxylate Hydrochloride
Packaging
10mg
Price
$45
Updated
2021/12/16
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Ethyl 1-aminocyclopropanecarboxylate hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

peptide synthesis

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

64-17-5

22059-21-8

42303-42-4

Thionyl chloride (150 mL, 2.056 mol) was slowly added to a suspension of 1-aminocyclopropanecarboxylic acid (100 g, 0.989 mol) in anhydrous ethanol (1 L) below 0 °C. The reaction mixture was stirred at 70 °C for 20 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent: methanol, Rf = 0.4) to confirm that most of the raw materials had been consumed. Upon completion of the reaction, the solution was concentrated to give 210 g of crude product. The residue was dissolved in water and the pH was adjusted to 9-10 with potassium carbonate.Subsequently, the aqueous layer was extracted with dichloromethane (1L x 3). The organic layers were combined and concentrated to dryness. The residue was dissolved in ethyl acetate (300 mL) and a hydrochloride solution of ethyl hydrochloride (250 mL, 4 M) was slowly added at below -30°C. The mixture was stirred at 0 °C for 30 min, during which time a solid precipitated. Filtration under nitrogen protection gave ethyl 1-aminocyclopropane-1-carboxylate hydrochloride (132 g, 80.6% yield) as a white solid. The 1H-NMR data of the free amine were as follows (400 MHz, chloroform-d): δ[ppm] = 0.91-1.02 (m, 2H), 1.15-1.30 (m, 5H), 2.17 (s, 2H), 4.10 (d, 2H).

References

[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 10, p. 1840 - 1846
[2] Patent: WO2014/147021, 2014, A2. Location in patent: Page/Page column 129
[3] Patent: WO2015/140195, 2015, A1. Location in patent: Page/Page column 92; 93
[4] Patent: US2006/25589, 2006, A1. Location in patent: Page/Page column 9

Ethyl 1-aminocyclopropanecarboxylate hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethyl 1-aminocyclopropanecarboxylate hydrochloride manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
1-Aminocyclopropane-1-carboxylic acid ethyl ester hydrochloride 42303-42-4
Price
US $1.10-9.90/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kg
Release date
2025-08-18
Career Henan Chemical Co
Product
H-ACPC-OET HCL 42303-42-4
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

42303-42-4, Ethyl 1-aminocyclopropanecarboxylate hydrochlorideRelated Search:

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