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Azlocillin sodium

Product Name
Azlocillin sodium
CAS No.
37091-65-9
Chemical Name
Azlocillin sodium
Synonyms
AZLOCILLIN SODIUM SALT;securopen;Prestwick_48;sodium azlocillin;AZLOCILLIN SODIUM;AZLOCILLINE SODIUM;Aloxicillin sodium;monosodiumazlocillin;D-alpha-([Imidazolidin;Azlocillin sodium, >=95%
CBNumber
CB2128131
Molecular Formula
C20H22N5NaO6S
Formula Weight
483.47
MOL File
37091-65-9.mol
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Azlocillin sodium Property

Melting point:
>199oC (dec.)
Flash point:
>110°(230°F)
storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: soluble50mg/mL
form 
powder
color 
White to Off-White
Water Solubility 
Freely soluble in water
Stability:
Hygroscopic
CAS DataBase Reference
37091-65-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
42/43
Safety Statements 
36
WGK Germany 
3
RTECS 
XH9250000
Toxicity
mouse,LD50,intramuscular,15420mg/kg (15420mg/kg),LUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: TREMORBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX),Antibiotiki i Meditsinskaya Biotekhnologiya. Antibiotics and Medical Biotechnology. Vol. 32, Pg. 453, 1987.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A7926
Product name
Azlocillin sodium salt
Packaging
1g
Price
$149
Updated
2024/03/01
Sigma-Aldrich
Product number
A7926
Product name
Azlocillin sodium salt
Packaging
5g
Price
$521
Updated
2023/06/20
Alfa Aesar
Product number
J66895
Product name
Azlocillin sodium, 90%
Packaging
10g
Price
$343
Updated
2021/12/16
Alfa Aesar
Product number
J66895
Product name
Azlocillin sodium, 90%
Packaging
1g
Price
$37.1
Updated
2021/12/16
Cayman Chemical
Product number
18424
Product name
Azlocillin (sodium salt)
Purity
≥95%
Packaging
250mg
Price
$32
Updated
2024/03/01
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Azlocillin sodium Chemical Properties,Usage,Production

Originator

Securopen,Bayer,W. Germany,1977

Uses

Antibacterial;Bacterial transpeptidase inhibitor

Uses

Azlocillin sodium is a semisynthetic penicillin and is a potent 1-lactam antibiotic. It is often used against Pseudomonas aeruginosa and has been used to develop novel antibiotic quantitation techniques.

Definition

ChEBI: Azlocillin sodium is an organic sodium salt. It contains an azlocillin(1-).

Manufacturing Process

3.8 parts by weight of D-(-)-α-[(imidazolidin-2-on-1-yl)carbonylamino]phenylacetic acid were dissolved in 65 parts by volume of dichloromethane. 2.7 parts by weight of 1-methyl-2-chloro-δ1-pyrrolinium chloride were added, and after cooling to -10°C 2.0 parts by volume of triethylamine were added gradually. This reaction mixture was then stirred for one hour at -5°C (mixture A). 4.0 parts by weight of 6-aminopenicillanic acid in 80 parts by volume of dichloromethane were treated with 4.4 parts by volume of triethylamine and 4.0 parts by weight of anhydrous sodium sulfate and then stirred for two hours at room temperature. After filtration, the solution was cooled to -20°C and combined with the mixture A. The reaction mixture was left to reach 0°C of its own accord, and was then stirred for a further hour at 0°C. The solvent was removed in a rotary evaporator, the residue was dissolved in water, and the solution was covered with a layer of ethyl acetate and acidified with dilute hydrochloric acid at 0° to 5°C, while stirring, until pH 1.5 was reached. The organic phase was then separated off, washed with water, dried over magnesium sulfate while cooling, and filtered, and after dilution with an equal amount of ether the sodium salt of the penicillin was precipitated from the filtrate by adding a solution of sodium 2-ethylcaproate dissolved in ether containing methanol. Yield: 1.3 parts by weight.

brand name

Azlin (Bayer).

Therapeutic Function

Antibacterial

Azlocillin sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Azlocillin sodium manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
Azlocillin sodium salt 37091-65-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99.912%
Supply Ability
10ton
Release date
2024-04-22
Hangzhou ICH Biofarm Co., Ltd
Product
Azlocillin sodium 37091-65-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.0%
Supply Ability
20 tons
Release date
2023-07-13
Hebei Mojin Biotechnology Co., Ltd
Product
Azlocillin sodium 37091-65-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-30

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