dihydroberberine

Product Name: dihydroberberine
CAS No.: 483-15-8
Chemical Name: dihydroberberine
Synonyms: Nsc331264;Dihydroberbine;dihydroberberine;Dihyddroberberine;DihydrouMbellatine;Dihydroberberine-RM;dihydroberberine CAS;Berberine Dihydro Impurity;Dihydroberberine/Dihydroumbellatine;9,10-Dimethoxy-2,3-(methylenedioxy)-13,13a-didehydrob
CBNumber: CB21331789
Molecular Formula: C20H19NO4
Formula Weight: 337.37
MOL File: 483-15-8.mol

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dihydroberberine Property

Melting point:: 223-224℃ (dec.)
Boiling point:: 557.8±50.0 °C(Predicted)
Density: 1.37±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in DMSO
pka: 3.08±0.20(Predicted)
form: crystals
color: Yellow
Water Solubility: Soluble to 57.46 mg/l in water
InChI: InChI=1S/C20H19NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-9H,5-6,10-11H2,1-2H3
InChIKey: FZAGOOYMTPGPGF-UHFFFAOYSA-N
SMILES: C12C=C3C(=CC=1CCN1C2=CC2=CC=C(OC)C(OC)=C2C1)OCO3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D446915
Product name: Dihydroberberine
Packaging: 10mg
Price: $125
Updated: 2021/12/16

Usbiological

Product number: 446983
Product name: Dihydroberberine
Packaging: 10mg
Price: $418
Updated: 2021/12/16

ChemScene

Product number: CS-0018246
Product name: Dihydroberberine
Packaging: 5mg
Price: $119
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb259203
Product name: Dihydroberberine
Purity: 98%
Packaging: 20mg
Price: $408
Updated: 2021/12/16

ChemScene

Product number: CS-0018246
Product name: Dihydroberberine
Packaging: 20mg
Price: $343
Updated: 2021/12/16

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dihydroberberine Chemical Properties,Usage,Production

Description

Dihydroberberine: a natural derivative of Berberine
Dihydroberberine (DHB) is emerging as a popular supplement for its enhanced bioavailability and therapeutic efficacy compared to its precursor, Berberine. Berberine, a natural compound, has been widely used for its antimicrobial and anti-inflammatory properties. It has also shown promise in improving glucose and lipid metabolism, supporting cardiovascular health, and offering neuroprotective effects.

Uses

Dihydroberberine is a derivative Berberine (B318150), an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2) which is abundantly expressed in colon cancer cells.

Definition

ChEBI: Lambertine is an alkaloid.

Synthesis

Briefly, 5% sodium hydroxide solution (27?mL) containing sodium borohydride (2.7?g) was added to a stirred solution of berberine chloride (11.06?g) and potash (13.1?g) in methanol (150?mL) dropwise. After stirring the reaction mixture at ambient temperature for 3?h, the precipitation was filtered and scrubbed with 30% ethanol (200?mL) followed by 80% ethanol (100?mL). The green–brown crystals were filtered and dried at 30?°C and were then collected to afford 9.4?g (yield: 85%) Dihydroberberine[1].

References

[1] Lihua Tan . “Dihydroberberine, a hydrogenated derivative of berberine firstly identified in Phellodendri Chinese Cortex, exerts anti-inflammatory effect via dual modulation of NF-κB and MAPK signaling pathways.” International immunopharmacology 75 (2019): Article 105802.

dihydroberberine Preparation Products And Raw materials

Raw materials

Preparation Products

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dihydroberberine Suppliers

China 145 India 1 United States 10 Global 156

Bonerge(Hunan) Lifescience Co., Ltd.

Tel: 17673648049
Email: Alav.w@bonerge.com
Country: China
ProdList: 11
Advantage: 58

ChengDu YiRui Bio-Technology CO., LTD

Tel: 182-24028459 18224018291
Fax: QQ137193152
Email: 3004072879@qq.com
Country: China
ProdList: 1195
Advantage: 58

SHANDONG XINGRUNDA CHEMICAL CO.,LTD

Tel: 18615348689 18615348689
Email: hclt1978@163.com
Country: China
ProdList: 27
Advantage: 58

Suzhou Sanyi Polymer Chemical Technology Co., Ltd.

Tel: +86-18151108777; 15262425018
Email: 1007487177@qq.com
Country: China
ProdList: 126
Advantage: 58

Nanjing Shangshu Biotechnology Co., Ltd

Tel: 18266960953 18266960953
Email: 907697096@qq.com
Country: China
ProdList: 3033
Advantage: 58

Shaanxi Kebele Pharmaceutical R&D Co., Ltd

Tel: 13119135307 13119135307
Email: 3866620171@qq.com
Country: China
ProdList: 1901
Advantage: 58

Lihe Biotechnology (Shandong) Co., Ltd

Tel: 15588824841 15588824841
Email: lhswsd@126.com
Country: China
ProdList: 29
Advantage: 58

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19182
Advantage: 64

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18738
Advantage: 57

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

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View Lastest Price from dihydroberberine manufacturers

Shaanxi Cuikang Pharmaceutical Technology Co., Ltd

Product: Dihydroberberine/Dihydroumbellatine 483-15-8
Price: US $600.00-400.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: Ex：10T
Release date: 2024-11-19

Hebei Weibang Biotechnology Co., Ltd

Product: dihydroberberine 483-15-8
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-14

Hangzhou Zelixir Biotech Co., Ltd.

Product: Dihydroberberine 483-15-8
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 99.5%
Supply Ability: 20ton
Release date: 2023-12-29

483-15-8, dihydroberberineRelated Search:

BERBERINE ACID SULFATE Berberine hydrochloride 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one VERATRIDINE Xanthiazone Daurinoline L-Hyoscyamine Xanthiside menisdaurin daurisoline VERATRINE veratramine epiberberine Tetrahydroberberine Tannic acid berberine Berberine Bisulfate

9,10-DiMethoxy-6,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline

Dihydroberberine/Dihydroumbellatine

9,10-Dimethoxy-2,3-(methylenedioxy)-13,13a-didehydrob

Dihydroberbine

dihydroberberine

5,8-Dihydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine

9,10-Dimethoxy-2,3-(methylenedioxy)-13,13a-didehydroberbine

Nsc331264

DihydrouMbellatine

Berberine Dihydro Impurity

6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine, 5,8-dihydro-9,10-dimethoxy-

9,10-Dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline

Dihyddroberberine

dihydroberberine CAS

Dihydroberberine-RM

483-15-8

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract