yakuchinone-A
- Product Name
- yakuchinone-A
- CAS No.
- 78954-23-1
- Chemical Name
- yakuchinone-A
- Synonyms
- yakuchinone-A;Yakuchinone A, 10 mM in DMSO;1-(4-Hydroxy-3-methoxyphenyl)-7-phenylheptan-3-one;3-Heptanone, 1-(4-hydroxy-3-methoxyphenyl)-7-phenyl-;1-(4'-hydroxy-3'-methoxyphenyl)-7-phenyl-3-heptanone
- CBNumber
- CB21344905
- Molecular Formula
- C20H24O3
- Formula Weight
- 312.4
- MOL File
- 78954-23-1.mol
yakuchinone-A Property
- Boiling point:
- 212-214 °C(Press: 2 Torr)
- Density
- 1.095±0.06 g/cm3(Predicted)
- solubility
- DMSO:0.0(Max Conc. mg/mL);0.0(Max Conc. mM)
- pka
- 10.02±0.20(Predicted)
- form
- Liquid
- color
- Colorless to off-white
- InChI
- InChI=1S/C20H24O3/c1-23-20-15-17(12-14-19(20)22)11-13-18(21)10-6-5-9-16-7-3-2-4-8-16/h2-4,7-8,12,14-15,22H,5-6,9-11,13H2,1H3
- InChIKey
- TXELARZTKDBEKS-UHFFFAOYSA-N
- SMILES
- C(C1=CC=C(O)C(OC)=C1)CC(=O)CCCCC1=CC=CC=C1
- LogP
- 3.720 (est)
N-Bromosuccinimide Price
- Product number
- Y0022
- Product name
- Yakuchinone A
- Packaging
- 50MG
- Price
- $312
- Updated
- 2025/07/31
yakuchinone-A Chemical Properties,Usage,Production
Uses
Yakuchinone A is a natural product isolated from the fruit of Alpinia oxyphylla, which can induce apoptosis and has anticancer and anti-inflammatory activities[1].
Definition
ChEBI: A ketone that is heptan-3-one substituted by a 4-hydroxy-3-methoxyphenyl group at position 1 and a phenyl group at position 7. Isolated from in Alpinia oxyphylla, it exhibits antineoplastic and inhibitory activities against COX-1, COX-2 and NO synthase.
in vivo
Yakuchinone A (50 mg/kg, i.p., daily, 14 days) can reduce the symptoms of EAE in mice in autoimmune encephalomyelitis (EAE) mouse model[1].
| Animal Model: | Female C57BL/6 mice[1] |
| Dosage: | 50 mg/kg |
| Administration: | i.p., daily, 14 days |
| Result: | Showed a significant EAE score reduction from Day 9 to Day 15 after EAE onset. |
References
[1] Chen Huo, et al. Microbial Transformation of Yakuchinone A and Cytotoxicity Evaluation of Its Metabolites.?Int J Mol Sci. 2022 Apr 3;23(7):3992.
[2] Kuo-Kuei Huang, et al. Alpinia oxyphylla?Fruit Extract Ameliorates Experimental Autoimmune Encephalomyelitis through the Regulation of Th1/Th17 Cells. Evid Based Complement Alternat Med. 2019 Mar 14;2019:6797030. DOI:10.1155/2019/6797030
yakuchinone-A Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from yakuchinone-A manufacturers
- Product
- Yakuchinone A 78954-23-1
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98% HPLC
- Supply Ability
- 100kg
- Release date
- 2024-01-10