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kukoamine A

Product Name
kukoamine A
CAS No.
75288-96-9
Chemical Name
kukoamine A
Synonyms
NSC5398;NSC 5398;NSC-5398;kukoamine A;1,14-Bis(dihydrocaffeoyl)spermidine;N1,N12-Bis(dihydrocaffeoyl) spermine;N,N'-[Tetramethylenebis(iminotrimethylene)]bis[3-(3,4-dihydroxyphenyl)propionamide];N,N'-[1,4-Butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxybenzenepropanamide];Benzenepropanamide,N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy-;N,N'-((butane-1,4-diylbis(azanediyl))bis(propane-3,1-diyl))bis(3-(3,4-dihydroxyphenyl)propanamide)
CBNumber
CB21355400
Molecular Formula
C28H42N4O6
Formula Weight
530.66
MOL File
75288-96-9.mol
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kukoamine A Property

Boiling point:
872.1±65.0 °C(Predicted)
Density 
1.213±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
pka
9.48±0.10(Predicted)
color 
Off-white to yellow
CAS DataBase Reference
75288-96-9
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL83866
Product name
Kukoamine A
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$688
Updated
2024/03/01
Cayman Chemical
Product number
25139
Product name
Kukoamine A
Purity
≥95%
Packaging
1mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
25139
Product name
Kukoamine A
Purity
≥95%
Packaging
5mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
25139
Product name
Kukoamine A
Purity
≥95%
Packaging
10mg
Price
$330
Updated
2024/03/01
Usbiological
Product number
300534
Product name
Kukoamine A
Packaging
10mg
Price
$618
Updated
2021/12/16
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kukoamine A Chemical Properties,Usage,Production

Description

Kukoamine A is a spermine alkaloid originally isolated from L. chinense that has diverse biological activities, including anticancer, neuroprotective, and anti-inflammatory properties. Kukoamine A (5-20 μg/ml) inhibits colony formation of U251 and WJ1 glioblastoma cells in a concentration-dependent manner. It halts the cell cycle at the G0/G1 phase and induces apoptosis when used at concentrations of 60 and 80 μg/ml. Kukoamine A (20 and 40 μM) induces autophagy and increases cell viability in an SH-SY5Y cell model of MPP-induced injury. It increases the number of dopamine neurons in the substantia nigra and striatum, decreases α-synuclein expression, and improves motor function in an MPTP mouse model of Parkinson’s disease when administered at a dose of 20 mg/kg per day. Kukoamine A (10 and 20 mg/kg) decreases IL-1β, TNF-α, and COX-2 protein levels in the hippocampus and increases hippocampal neurogenesis in a rat model of radiation injury. It also selectively inhibits trypanothione reductase (Ki = 1.8 μM), an enzyme that protects certain parasites from oxidative stress, over human glutathione reductase (Ki = >10 mM).

Occurrence

The root bark of Lychium chinense yields this alkaloid. Kukoamine A possesses hypotensive activity inducing hypotension in rats at a dose of 5 mg/kg when given intravenously.

Uses

Kukoamine A is a neuroprotective agent which is used to prevent the loss of dopaminergic neurons in substantia nigra.

Definition

ChEBI: Kukoamine A is an amine.

kukoamine A Preparation Products And Raw materials

Raw materials

Preparation Products

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kukoamine A Suppliers

China 89 United Kingdom 1 United States 7 Global 97
ALB Technology Limited
Tel
702-983-3769
Fax
702-983-3769
Email
sales@albtechnology.com
Country
United States
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55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
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60
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
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58
FortopChem Technology Limited
Tel
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Email
sales@fortopchem.com
Country
United States
ProdList
1099
Advantage
50
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
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80
MedChemExpress
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--
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
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58
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View Lastest Price from kukoamine A manufacturers

Career Henan Chemical Co
Product
kukoamine A 75288-96-9
Price
US $8.00/KG
Min. Order
1g
Purity
＞98% HPLC
Supply Ability
kg--ton
Release date
2020-02-20

75288-96-9, kukoamine ARelated Search:

Triptolide Xanthiside VERATRIDINE L-Hyoscyamine Xanthiazone Daurinoline 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one menisdaurin daurisoline veratramine VERATRINE 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Tributyl citrate (-)-Huperzine A CALYCOSIN KukoaMine B Spermidine

  • kukoamine A
  • 1,14-Bis(dihydrocaffeoyl)spermidine
  • N,N'-[1,4-Butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxybenzenepropanamide]
  • N,N'-[Tetramethylenebis(iminotrimethylene)]bis[3-(3,4-dihydroxyphenyl)propionamide]
  • N1,N12-Bis(dihydrocaffeoyl) spermine
  • Benzenepropanamide,N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy-
  • N,N'-((butane-1,4-diylbis(azanediyl))bis(propane-3,1-diyl))bis(3-(3,4-dihydroxyphenyl)propanamide)
  • NSC 5398
  • NSC5398
  • NSC-5398
  • 75288-96-9