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Propitocaine hydrochloride

Product Name
Propitocaine hydrochloride
CAS No.
1786-81-8
Chemical Name
Propitocaine hydrochloride
Synonyms
xylonest;Prilocaine HC;PRILOCAINE HCL;Citanest Plain;Prilocaine HCI;Ropitocaine Hcl;Propitocaine HCL;l-67hydrochloride;prilocainechloride;citanesthydrochloride
CBNumber
CB2139212
Molecular Formula
C13H21ClN2O
Formula Weight
256.77
MOL File
1786-81-8.mol
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Propitocaine hydrochloride Property

Melting point:
168-170°C
storage temp. 
2-8°C
solubility 
Freely soluble in water and in ethanol (96 per cent), very slightly soluble in acetone
color 
White to Off-White
Merck 
14,7743
InChI
InChI=1S/C13H20N2O.ClH/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2;/h5-8,11,14H,4,9H2,1-3H3,(H,15,16);1H
InChIKey
BJPJNTKRKALCPP-UHFFFAOYSA-N
SMILES
C1(=CC=CC=C1C)NC(=O)C(C)NCCC.Cl
CAS DataBase Reference
1786-81-8(CAS DataBase Reference)
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Safety

WGK Germany 
3
RTECS 
UG5775000
HS Code 
29242990
Toxicity
man,LDLo,parenteral,12343ug/kg/1H (12.343mg/kg),BLOOD: HEMORRHAGE,Journal of Analytical Toxicology. Vol. 10, Pg. 75, 1986.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3106
Product name
Prilocaine Hydrochloride
Purity
pharmaceutical secondary standard, certified reference material
Packaging
500MG
Price
$182
Updated
2024/03/01
Sigma-Aldrich
Product number
BP497
Product name
Prilocaine hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$257
Updated
2024/03/01
Sigma-Aldrich
Product number
1561008
Product name
Prilocaine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
P3347
Product name
Prilocaine hydrochloride
Purity
meets USP testing specifications
Packaging
1g
Price
$99
Updated
2022/05/15
Sigma-Aldrich
Product number
BP497
Product name
Prilocaine hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Price
$220
Updated
2021/12/16
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Propitocaine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

antibacterial

Uses

Propitocaine hydrochloride is a local anesthetic of the amino amide type,it is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/pril ocaine or EMLA), for treatment of conditions like paresthesia.

Uses

Anesthetic (local).

Definition

ChEBI: The monohydrochloride salt of prilocaine.

brand name

Citanest (AstraZeneca).

Biological Functions

Prilocaine hydrochloride (Citanest) is an amide anesthetic whose onset of action is slightly longer than that of lidocaine; its duration of action is comparable. Prilocaine is 40% less toxic acutely than lidocaine, making it especially suitable for regional anesthetic techniques. It is metabolized by the liver to orthotoluidine, which when it accumulates, can cause conversion of hemoglobin (HB+++ to methemoglobin (HB+++. Oxygen transport is impaired in the presence of methemoglobinemia. Treatment involves the use of reducing agents, such as methylene blue, given intravenously, to reconvert methemoglobin to hemoglobin.

Contact allergens

Prilocaine in a local anesthetic of the amide group. It can induce allergic contact dermatitis, particularly from EMLA? cream.

Side effects

Common adverse reactions include bradycardia, hypotension, urticaria, edema, anaphylactoid reactions, lightheadedness, nervousness, euphoria, confusion, dizziness, drowsiness, tinnitus. The safety and effectiveness of prilocaine depend on proper dosage, correct technique, adequate precautions, and readiness for emergencies.

Propitocaine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Propitocaine hydrochloride Suppliers

Canada 2 China 309 Europe 2 France 1 Germany 2 India 28 Japan 1 Russia 1 South Korea 1 Spain 1 Switzerland 2 United Kingdom 8 United States 31 USA 1 Global 390
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View Lastest Price from Propitocaine hydrochloride manufacturers

Jinan Million Pharmaceutical Co., Ltd
Product
Propitocaine hydrochloride 1786-81-8
Price
US $2.00/kg
Min. Order
0.10000000kg
Purity
99%
Supply Ability
200KG
Release date
2024-07-23
Hebei Miaoyin Technology Co.,Ltd
Product
Prilocaine hydrochloride 1786-81-8
Price
US $20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000
Release date
2023-04-06
hebei hongtan Biotechnology Co., Ltd
Product
Prilocaine hydrochloride 1786-81-8
Price
US $50.00-100.00/G
Min. Order
10G
Purity
98%
Supply Ability
2000KG
Release date
2024-06-06

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