ChemicalBook > CAS DataBase List > Amyloid β-Peptide (1-42) (human)

Amyloid β-Peptide (1-42) (human)

Product Name
Amyloid β-Peptide (1-42) (human)
CAS No.
107761-42-2
Chemical Name
Amyloid β-Peptide (1-42) (human)
Synonyms
TB500;Soy Peptide Powder;DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA;DA-42;soy peptide;β-Amyloid-42;Soy Oligopeptides;Amyloid β Protein Fragment 1-42;Amyloid β-Peptide (1-42) (human);Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
CBNumber
CB2139797
Molecular Formula
C203H311N55O60S1
Formula Weight
4514.04
MOL File
107761-42-2.mol
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Amyloid β-Peptide (1-42) (human) Property

Melting point:
205 °C
Density 
0.23 g/cm3
storage temp. 
-20°C
solubility 
Soluble in ammonium hydroxide, pH >9. Also soluble in DMSO.
form 
Lyophilized
color 
Lyophilized White
Odor
Odorless
Sequence
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
InChIKey
XPESWQNHKICWDY-QYFPAAMGSA-N
CAS DataBase Reference
107761-42-2(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29332900
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A9810
Product name
Amyloid β Protein Fragment 1-42
Packaging
0.1mg
Price
$299
Updated
2024/03/01
Sigma-Aldrich
Product number
171596
Product name
β-Amyloid Peptide (1-42), Rat
Packaging
250μg
Price
$445
Updated
2024/03/01
Alfa Aesar
Product number
J66387
Product name
Amyloid beta (1-42), human
Packaging
0.5mg
Price
$354
Updated
2023/06/20
Alfa Aesar
Product number
J66387
Product name
Amyloid beta (1-42), human
Packaging
1mg
Price
$564
Updated
2023/06/20
Cayman Chemical
Product number
20574
Product name
Amyloid-β (1-42) Peptide
Purity
≥96%
Packaging
1mg
Price
$276
Updated
2021/12/16
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Amyloid β-Peptide (1-42) (human) Chemical Properties,Usage,Production

Chemical Properties

Lyophilized White solid, with no soy flavor, no protein denaturation, acidic non-precipitation, heating does not coagulate, easily soluble in water, good fluidity, and other good processing properties, is an excellent health food material.

Uses

Amyloid β-Peptide (1-42) (human)[107761-42-2], a major component of amyloid plaques, accumulates in neurons of Alzheimer's disease brains. Aβ(s) peptides, their peptide fragments and mutated fragments are used to study a wide range of metabolic and regulatory functions including activation of kinases, regulation of cholesterol transport, function as a transcription factor, and regulators of inflammation. Aβ(s) peptides and their peptide fragments are also used to study oxidative stress, metal binding and mechanisms of protein cross-linking in the context of diseases such as Alzheimer's disease and neurodegeneration.

Application

Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Beta-Amyloid (1-42) human is used as follows:
for the production of Aβ-1-42 oligomer;
in western blot analysis;
for interference testing of immunomagnetic reduction (IMR) plasma Aβ42 assay;
to study the effect of resveratrol on Aβ-1-42-induced impairment of spatial learning, memory, and synaptic plasticity;
to investigate the effect of Aβ in epithelial cell cultures.

General Description

Amyloid β Protein is produced from amyloid-β precursor protein (APP). It consists of two C terminal variants, such as a long tailed Aβ 1-42 and a short tailed Aβ 1-40. APP is located on human chromosome 21q21.3.

Biochem/physiol Actions

Amyloid β-Peptide (1-42) (human) is a human form of the predominant amyloid β-peptide found in the brains of patients with Alzheimer's disease. Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties. Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome. Aβ 1-42 regulates cholesterol transport and may function as a transcription factor. It may possess anti-inflammatory and antimicrobial properties. Downregulates bcl-2 and increases the levels of bax. Neurotoxic.

storage

-20°C

References

[1] CHEN L M, CHAI K X. Matriptase cleaves the amyloid-beta peptide 1–42 at Arg-5, Lys-16, and Lys-28[J]. BMC Research Notes, 2019, 12. DOI:10.1186/s13104-018-4040-z.
[2] BROWN A M, BEVAN D R. Influence of sequence and lipid type on membrane perturbation by human and rat amyloid β-peptide (1-42).[J]. Archives of biochemistry and biophysics, 2015, 614: 1-13. DOI:10.1016/j.abb.2016.11.006.
[3] MENGTING YANG. Gel Phase Membrane Retards Amyloid β-Peptide (1–42) Fibrillation by Restricting Slaved Diffusion of Peptides on Lipid Bilayers[J]. Langmuir, 2018, 34 28: 8408-8414. DOI:10.1021/acs.langmuir.8b01315.
[4] LIANG SHEN Hong F J. Comparative study on the conformational stability of human and murine amyloid β peptide[J]. Computational and Theoretical Chemistry, 2011, 972 1: Pages 44-47. DOI:10.1016/j.comptc.2011.06.012.
[5] MOUCHARD A, BOUTONNET M C, MAZZOCCO C, et al. ApoE-fragment/Aβ heteromers in the brain of patients with Alzheimer’s disease[J]. Scientific Reports, 2019, 9. DOI:10.1038/s41598-019-40438-4.

Amyloid β-Peptide (1-42) (human) Preparation Products And Raw materials

Raw materials

Preparation Products

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Amyloid β-Peptide (1-42) (human) Suppliers

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View Lastest Price from Amyloid β-Peptide (1-42) (human) manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
beta-Amyloid (1-42) human 107761-42-2
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000KG
Release date
2023-09-05
Hebei Mujin Biotechnology Co.,Ltd
Product
Amyloid β-Peptide (1-42) (human) 107761-42-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-28
Shandong Hanjiang Chemical Co., Ltd
Product
TB500 75591-33-4
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10T
Release date
2024-01-10

107761-42-2, Amyloid β-Peptide (1-42) (human)Related Search:

α-Lipoic Acid Diethylstilbestrol Oxytocin Amyloid β-Protein (1-42) (mouse, rat) AMYLOID BETA-PROTEIN (29-40) H-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-OH H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE H-ILE-ILE-GLY-LEU-MET-OH H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH AMYLOID BETA-PROTEIN (1-15) H-CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH PHENYLSELENOL Aluminum acetylacetonate Benzyl isocyanide TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) SALCOMINE

  • Bate-Amyloid（1-42）human
  • </span> (1-42) (human)
  • AB42, betaamyloid peptide
  • Amyloid <span class="symbol">&beta
  • H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
  • REF DUPL: H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
  • Beta-Amyloid (1-42), sodium salt
  • Β-AMYLOID PEPTIDE (1-42), RAT
  • Amyloid β-Peptide (1-42) (human)
  • AMyloid (1-42) huMan peptide
  • HuMan β-aMyloid peptide-(1-42)
  • AMyloid b-Protein (1-42)
  • β-AMyloid Peptide (1-42),rat,β-AMyloid Peptide (1-42),rat
  • Beta-AMyloid(1-42)TB500
  • TB500
  • Soy Oligopeptides
  • Amyloid-β (1-42) Peptide
  • Amyloid|A-Peptide (1-42) (human)
  • Amyloid β Protein Fragment 1-42, ≥95% (HPLC)
  • L-alpha-Aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-serylglycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine
  • M.W. 4514.08 C203H311N55O60S
  • Amyloid β-Protein (1-42) (HFIP-treated)
  • Amyloid β-Protein (1-42) sodium salt
  • β–Amyloid (1-42), Amyloid β-Protein (Human, 1-42)
  • 2-Amyloid(1-42) Human
  • soy peptide
  • 1-42 Amyloid β Protein Fragment 1-42,human
  • Amyloid beta Protein fragment 1-42 HCl Salt
  • Human beta-amyloid peptide (1-42)
  • Amyloid β-Protein (1-42) hydrochloride salt
  • Bate-Amyloid(1-42)
  • BETA-AMYLOID PEPTIDE (1-42), HUMAN
  • DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
  • AMYLOID BETA-PEPTIDE (1-42) (HUMAN)
  • AMYLOID B-PROTEIN FRAGMENT 1-42
  • Amyloidb-Peptide(1-42)(human)
  • H-Asp-Ala-Glu-Phe-Arg-His-Asp--Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-OH
  • SS-AMYLOID PEPTIDE (1-42), RAT
  • H-asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Gly-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Ile-Ala-OH
  • Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
  • beta-Amyloid (1-42) human
  • Amyloid beta-Protein (1-42) hydrochloride salt H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH hydrochloride salt
  • Amyloid beta-Protein (1-42) sodium salt
  • Amyloid beta-Protein (1-42) trifluoroacetate salt H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH trifluoroacetate salt
  • Amyloid β-Peptide (1-42) (human) TFA
  • β-Amyloid-42
  • β-Amyloid: 1-42,human
  • Amyloid β-Peptide (12-28) (human)
  • Amyloid β Protein Fragment 1-42
  • DA-42
  • Amyloid β-Peptide (1-42)
  • beta-Amyloid (1-42) human USP/EP/BP
  • β-Amyloid (1-42), human TFA
  • Amyloid β-Protein (1-42)
  • Soy Peptide Powder
  • β–Amyloid (1-42), human, Amyloid β-Protein (Human, 1-42)
  • beta-Amyloid (1-42) human/TB500
  • beta-Amyloid (1-42) humanbeta-Amyloid