Amyloid β-Peptide (1-42) (human)
- Product Name
- Amyloid β-Peptide (1-42) (human)
- CAS No.
- 107761-42-2
- Chemical Name
- Amyloid β-Peptide (1-42) (human)
- Synonyms
- TB500;Soy Peptide Powder;DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA;DA-42;soy peptide;β-Amyloid-42;Soy Oligopeptides;Amyloid β Protein Fragment 1-42;Amyloid β-Peptide (1-42) (human);Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
- CBNumber
- CB2139797
- Molecular Formula
- C203H311N55O60S1
- Formula Weight
- 4514.04
- MOL File
- 107761-42-2.mol
Amyloid β-Peptide (1-42) (human) Property
- storage temp.
- -20°C
- solubility
- Soluble in ammonium hydroxide, pH >9. Also soluble in DMSO.
- form
- Lyophilized
- color
- Lyophilized White
- Sequence
- H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
- InChIKey
- XPESWQNHKICWDY-QYFPAAMGSA-N
- CAS DataBase Reference
- 107761-42-2(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29332900
N-Bromosuccinimide Price
- Product number
- A9810
- Product name
- Amyloid β Protein Fragment 1-42
- Packaging
- 0.1mg
- Price
- $299
- Updated
- 2024/03/01
- Product number
- 171596
- Product name
- β-Amyloid Peptide (1-42), Rat
- Packaging
- 250μg
- Price
- $445
- Updated
- 2024/03/01
- Product number
- J66387
- Product name
- Amyloid beta (1-42), human
- Packaging
- 0.5mg
- Price
- $354
- Updated
- 2023/06/20
- Product number
- J66387
- Product name
- Amyloid beta (1-42), human
- Packaging
- 1mg
- Price
- $564
- Updated
- 2023/06/20
- Product number
- 20574
- Product name
- Amyloid-β (1-42) Peptide
- Purity
- ≥96%
- Packaging
- 1mg
- Price
- $276
- Updated
- 2021/12/16
Amyloid β-Peptide (1-42) (human) Chemical Properties,Usage,Production
Chemical Properties
Lyophilized White solid, with no soy flavor, no protein denaturation, acidic non-precipitation, heating does not coagulate, easily soluble in water, good fluidity, and other good processing properties, is an excellent health food material.
Uses
Amyloid β-Peptide (1-42) (human)[107761-42-2], a major component of amyloid plaques, accumulates in neurons of Alzheimer's disease brains. Aβ(s) peptides, their peptide fragments and mutated fragments are used to study a wide range of metabolic and regulatory functions including activation of kinases, regulation of cholesterol transport, function as a transcription factor, and regulators of inflammation. Aβ(s) peptides and their peptide fragments are also used to study oxidative stress, metal binding and mechanisms of protein cross-linking in the context of diseases such as Alzheimer's disease and neurodegeneration.
Application
Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Beta-Amyloid (1-42) human is used as follows:
for the production of Aβ-1-42 oligomer;
in western blot analysis;
for interference testing of immunomagnetic reduction (IMR) plasma Aβ42 assay;
to study the effect of resveratrol on Aβ-1-42-induced impairment of spatial learning, memory, and synaptic plasticity;
to investigate the effect of Aβ in epithelial cell cultures.
General Description
Amyloid β Protein is produced from amyloid-β precursor protein (APP). It consists of two C terminal variants, such as a long tailed Aβ 1-42 and a short tailed Aβ 1-40. APP is located on human chromosome 21q21.3.
Biochem/physiol Actions
Amyloid β-Peptide (1-42) (human) is a human form of the predominant amyloid β-peptide found in the brains of patients with Alzheimer's disease. Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties. Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome. Aβ 1-42 regulates cholesterol transport and may function as a transcription factor. It may possess anti-inflammatory and antimicrobial properties. Downregulates bcl-2 and increases the levels of bax. Neurotoxic.
storage
-20°C
References
[1] CHEN L M, CHAI K X. Matriptase cleaves the amyloid-beta peptide 1–42 at Arg-5, Lys-16, and Lys-28[J]. BMC Research Notes, 2019, 12. DOI:10.1186/s13104-018-4040-z.
[2] BROWN A M, BEVAN D R. Influence of sequence and lipid type on membrane perturbation by human and rat amyloid β-peptide (1-42).[J]. Archives of biochemistry and biophysics, 2015, 614: 1-13. DOI:10.1016/j.abb.2016.11.006.
[3] MENGTING YANG. Gel Phase Membrane Retards Amyloid β-Peptide (1–42) Fibrillation by Restricting Slaved Diffusion of Peptides on Lipid Bilayers[J]. Langmuir, 2018, 34 28: 8408-8414. DOI:10.1021/acs.langmuir.8b01315.
[4] LIANG SHEN Hong F J. Comparative study on the conformational stability of human and murine amyloid β peptide[J]. Computational and Theoretical Chemistry, 2011, 972 1: Pages 44-47. DOI:10.1016/j.comptc.2011.06.012.
[5] MOUCHARD A, BOUTONNET M C, MAZZOCCO C, et al. ApoE-fragment/Aβ heteromers in the brain of patients with Alzheimer’s disease[J]. Scientific Reports, 2019, 9. DOI:10.1038/s41598-019-40438-4.
Amyloid β-Peptide (1-42) (human) Preparation Products And Raw materials
Raw materials
Preparation Products
Amyloid β-Peptide (1-42) (human) Suppliers
- Tel
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- info@polypeptide.de
- Country
- Germany
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- 408
- Advantage
- 66
- Tel
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- sales@chemcube.eu
- Country
- Germany
- ProdList
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- Tel
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- info@biotrend.ch
- Country
- Germany
- ProdList
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- Advantage
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- Tel
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- Fax
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- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
View Lastest Price from Amyloid β-Peptide (1-42) (human) manufacturers
- Product
- TB500 107761-42-2
- Price
- US $80.00/box
- Min. Order
- 1box
- Purity
- 99%
- Supply Ability
- 1000box/month
- Release date
- 2024-11-14
- Product
- Amyloid β-Peptide (1-42) (human) 107761-42-2
- Price
- US $80.00-75.00/box
- Min. Order
- 1box
- Purity
- 99.9+
- Supply Ability
- 2000box
- Release date
- 2024-05-24
- Product
- Amyloid β-Peptide (1-42) (human) 107761-42-2
- Price
- US $80.00-75.00/box
- Min. Order
- 1box
- Purity
- 99.9+
- Supply Ability
- 2000box
- Release date
- 2024-05-24