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Uridine 5′-monophosphate disodium salt

Product Name
Uridine 5′-monophosphate disodium salt
CAS No.
3387-36-8
Chemical Name
Uridine 5′-monophosphate disodium salt
Synonyms
SodiuM ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methyl phosphate;UMP 2NA;UMP, NA2;NSC 20257;5'-UMP-NA2;5`-UMP,2Na;disodiumump;UMP DISODIUM;5’-umpdisodium;disodium5’-ump
CBNumber
CB2154253
Molecular Formula
C9H14N2NaO9P
Formula Weight
348.18
MOL File
3387-36-8.mol
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Uridine 5′-monophosphate disodium salt Property

Melting point:
208-210 °C
refractive index 
-14 ° (C=1, H2O)
storage temp. 
2-8°C
solubility 
Water (Slightly)
form 
Crystalline Powder
pka
6.4, 9.5(at 25℃)
color 
White
Water Solubility 
40 g/100 mL (20 ºC)
BRN 
3582885
Stability:
Very Hygroscopic
InChI
InChI=1/C9H13N2O9P.Na.H/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18);;/t4-,6-,7-,8-;;/s3
InChIKey
KURVIXMFFSNONZ-WFIJOQBCSA-L
SMILES
O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(=O)NC1=O)O.[NaH] |&1:1,2,3,11,r|
CAS DataBase Reference
3387-36-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
2
RTECS 
YU7975000
F 
10-21
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
U6375
Product name
Uridine 5′-monophosphate disodium salt
Purity
≥99%
Packaging
1g
Price
$50.1
Updated
2024/03/01
Sigma-Aldrich
Product number
1222400
Product name
Disodium 5′-uridylate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$377
Updated
2024/03/01
TCI Chemical
Product number
U0021
Product name
Uridine 5'-Monophosphate Disodium Salt Hydrate
Purity
>98.0%(HPLC)
Packaging
5g
Price
$89
Updated
2024/03/01
TCI Chemical
Product number
U0021
Product name
Uridine 5'-Monophosphate Disodium Salt Hydrate
Purity
>98.0%(HPLC)
Packaging
25g
Price
$246
Updated
2024/03/01
Alfa Aesar
Product number
A18601
Product name
Uridine-5'-monophosphate disodium salt, 99%
Packaging
5g
Price
$78.4
Updated
2024/03/01
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Uridine 5′-monophosphate disodium salt Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Chemical Properties

The protonation of disodium uridine-5'-monophosphate (UMP) and cytidine 5' -monophosphate (a homolog of UMP) not only depend on the electrostatic forces but also strongly depend on the solute–solvent interactions of the different species in the mixtures. In the case of UMP, the correlation analysis of log10 K2 and log10 K1 (including β and π*) shows the polarity parameter has a major role (about 58 and 56 %, respectively) and the negative sign of π* and positive sign of β indicate that a decrease in the polarity of the media increases the protonation constants[1].

Uses

A nucleotide that is a major component of ribonucleic acid. It is found in dietary supplements as well as natural RNA rich foods and has been shown to increase cognitive function in animals.

Uses

Uridine 5’-Monophosphate Disodium Salt is a derivative of Uridine (U829910) which is a major ribonucleic acid.

Uses

Uridine 5′-monophosphate disodium salt has been used to study the effect of pyrimidine synthesis inhibitor, 5-azacytidine, on cholesterol and lipid metabolism. It has been used to study the effect of nucleotides on growth of specific intestinal bacteria.

Application

Uridine 5′-monophosphate disodium salt can be used as a cross-linking agent to prepare thermosensitive chitosan hydrogels containing graphene oxide as nanofillers. The hydrogels are attractive materials for use as scaffolds for the regeneration of damaged tissues[3].

benefits

Membrane phospholipids like phosphatidylcholine (PC) are required for cellular growth and repair, specifically for synaptic function. PC synthesis is controlled by cellular levels of its precursor, cytidine-5'-diphosphate choline (CDP-choline), which is produced from cytidine triphosphate (CTP) and phosphocholine. In rat PC12 cells, exogenous uridine was shown to elevate intracellular CDP-choline levels by promoting the synthesis of uridine triphosphate (UTP), which was partly converted to CTP. In such cells, uridine also enhances the neurite outgrowth produced by the nerve growth factor (NGF). A study assessed the effect of dietary supplementation with uridine-5'-monophosphate disodium (UMP-2Na+, an additive in infant milk formulas) on striatal dopamine (DA) release in aged rats. Potassium (K+)-evoked DA release was significantly greater among UMP-treated rats, i.e., 341+/-21% of basal levels vs. 283+/-9% of basal levels in control rats (p<0.05); basal DA release was unchanged. The levels of neurofilament-70 and neurofilament-M proteins, biomarkers of neurite outgrowth, increased to 182+/-25% (p<0.05) and 221+/-34% (p<0.01) of control values, respectively, with UMP consumption. Hence, UMP treatment not only enhances membrane phosphatide production but also can modulate two membrane-dependent processes, neurotransmitter release and neurite outgrowth, in vivo[2].

General Description

Uridine 5′-monophosphate is a pyrimidine mononucleotide. It is formed by decarboxylation of orotidine 5′-monophosphate. UMP is further converted to UTP (uridine 5′-triphosphate) using kinases.

References

[1] Soleimani, Farahnaz, and F. Gharib. "Protonation Constants of Uridine 5′-Monophosphate in Different Aqueous Solutions of Methanol." Journal of Solution Chemistry 43.4(2014):763-773.
[2] Lei Wang. “Dietary uridine-5′-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats.” Journal of Molecular Neuroscience 27 1 (2005): 137–145.
[3] KATARZYNA PIEKLARZ. Nanoarchitectonics and Biological Properties of Nanocomposite Thermosensitive Chitosan Hydrogels Obtained with the Use of Uridine 5’-Monophosphate Disodium Salt.[J]. International Journal of Molecular Sciences, 2024. DOI:10.3390/ijms25115989.

Uridine 5′-monophosphate disodium salt Preparation Products And Raw materials

Raw materials

Ribonucleic acid Nuclease Sodium hydroxide

Preparation Products

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Uridine 5′-monophosphate disodium salt Suppliers

Belgium 1 Canada 1 China 492 Europe 2 Germany 7 India 13 Italy 2 Japan 3 Slovakia 1 South Korea 1 Switzerland 1 United Kingdom 8 United States 36 USA 1 Global 569
TCI Chemicals (India) Pvt. Ltd.
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View Lastest Price from Uridine 5′-monophosphate disodium salt manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
5’-Uridine monophosphate disodium salt;UMP;UMP-Na2 3387-36-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.0%min. HPLC
Supply Ability
1000kg
Release date
2024-11-21
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Uridine 5′-monophosphate disodium salt 3387-36-8
Price
US $1000.00-400.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-12
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Uridine-5-Monophosphate 3387-36-8
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-12-03

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