ChemicalBook > CAS DataBase List > 3-Cyanoindole

3-Cyanoindole

Product Name
3-Cyanoindole
CAS No.
5457-28-3
Chemical Name
3-Cyanoindole
Synonyms
NSC 24935;3-indole A;3-CYANOINDOLE;3-Indonylnitrile;3-Cyanoindole 98%;3-Cyanoindole ,98%;3-CYANOINDOLE (ICN);RARECHEM AH BS 0093;3-INDOLECARBONITRILE;INDOLE-3-CARBONITRILE
CBNumber
CB2157658
Molecular Formula
C9H6N2
Formula Weight
142.16
MOL File
5457-28-3.mol
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3-Cyanoindole Property

Melting point:
179-182 °C (lit.)
Boiling point:
249.72°C (rough estimate)
Density 
1.1777 (rough estimate)
refractive index 
1.6211 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
14.61±0.30(Predicted)
color 
Orange to Brown
Water Solubility 
Insoluble in water.
Sensitive 
Air & Light Sensitive
BRN 
120888
CAS DataBase Reference
5457-28-3(CAS DataBase Reference)
NIST Chemistry Reference
3-Indolecarbonitrile(5457-28-3)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-37/39-36/37/39
RIDADR 
3439
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
III
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
A16041
Product name
Indole-3-carbonitrile, 98%
Packaging
1g
Price
$39.65
Updated
2024/03/01
Alfa Aesar
Product number
A16041
Product name
Indole-3-carbonitrile, 98%
Packaging
5g
Price
$132.65
Updated
2024/03/01
Alfa Aesar
Product number
A16041
Product name
Indole-3-carbonitrile, 98%
Packaging
25g
Price
$431
Updated
2021/12/16
TRC
Product number
C987993
Product name
3-Cyanoindole
Packaging
50g
Price
$70
Updated
2021/12/16
Matrix Scientific
Product number
064203
Product name
1H-Indole-3-carbonitrile
Purity
95+%
Packaging
1g
Price
$10
Updated
2021/12/16
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3-Cyanoindole Chemical Properties,Usage,Production

Chemical Properties

brown-grey to brown crystalline powder

Uses

3-Cyanoindole (cas# 5457-28-3) is a compound useful in organic synthesis.

Uses

Reactant for preparation of:

  • Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
  • Inhibitors of the C-terminal domain of RNA polymerase II with antitumor activities
  • 4-substituted β-lactams
  • Biologically active Indoles
  • Inhibitors of glycogen synthase kinase 3β (GSK-3)
  • HIV-1 integrase inhibitors
  • Indole fragments as inosine monophosphate dehydrogenase (IMPDH) inhibitors
  • Aziridinomitosene skeleton
  • Potential antiviral agents

Reactant for:
  • Intramolecular oxidative C-H coupling reactions with applications in medium-ring synthesis techniques

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 5, p. 656, 1973
Tetrahedron, 50, p. 6549, 1994 DOI: 10.1016/S0040-4020(01)89685-X
Tetrahedron Letters, 18, p. 4417, 1977 DOI: 10.1016/S0040-4039(01)83524-3

General Description

3-Cyanoindole undergoes regiospecific bromination to afford 6-bromo-3-cyanoindole. 3-Cyanoindole is formed during the flash vacuum thermolysis (FVT) of 3-azidoquinoline.

3-Cyanoindole Preparation Products And Raw materials

Raw materials

Indole-3-carboxaldehyde Ammonium phosphate dibasic

Preparation Products

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View Lastest Price from 3-Cyanoindole manufacturers

Career Henan Chemical Co
Product
3-Cyanoindole 5457-28-3
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
as request
Release date
2018-12-24

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