Uses
ChemicalBook > CAS DataBase List > 3-Bromo-2,6-dimethylpyridine

3-Bromo-2,6-dimethylpyridine

Uses
Product Name
3-Bromo-2,6-dimethylpyridine
CAS No.
3430-31-7
Chemical Name
3-Bromo-2,6-dimethylpyridine
Synonyms
6-dimethylpyridine;3-Bromo-2,6-dimethyl;3-Bromo-6-methyl-2-picolin;3-Bromo-6-methyl-2-picoline;2,6-Dimethyl-3-bromopyridine;3-BROMO-2,6-DIMETHYLPYRIDINE;Pyridine, 3-bromo-2,6-dimethyl-;3-Bromo-2,6-dimethylpyridine 98%;3-Bromo-2,6-dimethylpyridine ,97%;2,6-Dimethylpyridine-3-Bromopyridine
CBNumber
CB2161200
Molecular Formula
C7H8BrN
Formula Weight
186.05
MOL File
3430-31-7.mol
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3-Bromo-2,6-dimethylpyridine Property

Boiling point:
56-58°C 2mm
Density 
1.431 g/mL at 25 °C
refractive index 
n20/D1.552
Flash point:
86℃
storage temp. 
Inert atmosphere,Room Temperature
form 
liquid
pka
4.32±0.10(Predicted)
color 
Clear, colourless
InChI
InChI=1S/C7H8BrN/c1-5-3-4-7(8)6(2)9-5/h3-4H,1-2H3
InChIKey
TUJVGHCSNXCAFE-UHFFFAOYSA-N
SMILES
C1(C)=NC(C)=CC=C1Br
CAS DataBase Reference
3430-31-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-41-37/38-22
Safety Statements 
26-36/37/39-36/39
RIDADR 
UN1760
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
734799
Product name
3-Bromo-2,6-dimethylpyridine
Purity
97%
Packaging
5g
Price
$94.1
Updated
2025/07/31
TRC
Product number
B691763
Product name
3-Bromo-2,6-dimethylpyridine
Packaging
250mg
Price
$55
Updated
2021/12/16
Apolloscientific
Product number
OR6452
Product name
3-Bromo-2,6-dimethylpyridine
Purity
98%
Packaging
5g
Price
$38
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-9-H2
Product name
3-Bromo-2,6-dimethylpyridine
Purity
98%
Packaging
5G
Price
$42
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB55319
Product name
3-Bromo-2,6-lutidine
Packaging
2g
Price
$50
Updated
2021/12/16
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3-Bromo-2,6-dimethylpyridine Chemical Properties,Usage,Production

Uses

2,6-Dimethyl-3-bromopyridine is an important organic synthesis intermediate with wide applications in pharmaceuticals and pesticides. For example, it can be used to synthesize a new generation of quinolone antibacterial drug—balofloxacin.

Synthesis

108-48-5

3430-31-7

General procedure for the synthesis of 2,6-dimethyl-3-bromopyridine from 2,6-dimethylpyridine: 2,6-dimethylpyridine (115 kg, 1073.3 mol) was slowly added to pre-cooled fuming sulphuric acid (20-23%, 1015 kg, 2276.7 mol) over a period of 4.5 h at 0 °C, and the reaction temperature was maintained below 14 °C. The reaction temperature was kept below 14 °C. Subsequently, bromine (88.18 kg, 1103.6 mol) was added dropwise over 1 h at 5-10 °C. The reaction mixture was slowly warmed up to 150 °C over 12 hours. Analysis by TLC showed that about 40-50% of the feedstock was converted to the target product, while about 5% of the dimer by-product was generated. After cooling the reaction mixture to room temperature, bromine (88.18 kg, 1103.6 mol) was again added slowly. The reaction mixture was slowly heated to 65-75 °C over a period of 15 h. TLC analysis showed that the product conversion increased to 65-70% and the dimer by-product generation was maintained at 5%. The reaction mixture was quenched by the addition of water (500 L) and the reaction temperature was controlled below 20 °C during quenching. Subsequently, the reaction mixture was alkalized with 6.6 M NaOH solution (3800 L) and the temperature was controlled below 40 °C during alkalization. Ethyl acetate (220 L) was added and the mixture was stirred for 1 hour and then left to stand for 2 hours. The organic and aqueous layers were separated and the aqueous layer was treated with a solution of NaOH (10 kg) in water (10 L) and then extracted with ethyl acetate (160 L). The organic extracts were combined, washed with brine (100 L), dried with anhydrous sodium sulfate (50.0 kg), filtered and the solvent evaporated at atmospheric pressure. The residue was subjected to vacuum distillation and the fractions were collected at 58-60 °C and 2 mmHg to give 2,6-dimethyl-3-bromopyridine (98.45 kg, 49.2% yield) as a colorless liquid.

References

[1] Bioorganic Chemistry, 2004, vol. 32, # 1, p. 13 - 25
[2] Patent: WO2016/29216, 2016, A2. Location in patent: Page/Page column 83
[3] Patent: WO2018/81513, 2018, A1. Location in patent: Page/Page column 64
[4] Angewandte Chemie - International Edition, 2016, vol. 55, # 44, p. 13744 - 13748
[5] Angew. Chem., 2016, vol. 128, p. 13948 - 13952,5

3-Bromo-2,6-dimethylpyridine Preparation Products And Raw materials

Raw materials

FUMING SULFURIC ACID 2,6-Lutidine Ethyl acetate Bromine Sodium hydroxide

Preparation Products

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3-Bromo-2,6-dimethylpyridine Suppliers

China 204 Germany 5 India 9 The Netherlands 1 United Kingdom 5 United States 19 Global 243
Carbosynth
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sales@carbosynth.com
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United Kingdom
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Apollo Scientific Ltd.
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sales@apolloscientific.co.uk
Country
United Kingdom
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Leancare Ltd.
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enquiry@leancare.co.uk
Country
United Kingdom
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6446
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CARBONE SCIENTIFIC CO.,LTD
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sales@carbonesci.com
Country
United Kingdom
ProdList
6666
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UK GREEN SCIENTIFIC CO.,LIMITED
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Email
sales@gs-chem.com
Country
United Kingdom
ProdList
6098
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View Lastest Price from 3-Bromo-2,6-dimethylpyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
3-Bromo-2,6-dimethylpyridine 3430-31-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-17
Dideu Industries Group Limited
Product
3-Bromo-2,6-dimethylpyridine 3430-31-7
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-18
Zhuozhou Wenxi import and Export Co., Ltd
Product
3-Bromo-2,6-dimethylpyridine 3430-31-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

3430-31-7, 3-Bromo-2,6-dimethylpyridineRelated Search:

3,5-DIBROMO-2,4,6-TRIMETHYLPYRIDINE 2-BROMO-4,6-DIMETHYLPYRIDINE 3-Bromo-2,4,6-trimethylpyridine BIS(2,4,6-TRIMETHYLPYRIDINE)BROMONIUM HEXAFLUOROPHOSPHATE 3-Bromo-2,6-dimethylpyridine 2,6-Dimethyl-3,5-dibromopyridine 3-AMINO-2-BROMO-4,6-DIMETHYLPYRIDINE,5-Amino-2-bromo-4,6-dimethylpyridine 2-AMINO-3-BROMO-5,6-DIMETHYLPYRIDINE 4-Bromo-2,6-dimethylpyridine 2-AMINO-5-BROMO-3,4-DIMETHYLPYRIDINE 97%,2-AMINO-5-BROMO-3,4-DIMETHYLPYRIDINE 3-Bromo-2,5-dimethylpyridine Dimethyl 5-bromopyridine-2,3-dicarboxylate 6-Amino-2,4-dimethyl-3-bromopyridine 3-BROMO-2,4-DIMETHYLPYRIDINE 2,6-Lutidine 5-BROMO-6-CYANOPYRIDINE-2-CARBOXYLIC ACID 3,4-DIBROMO-2,6-DIMETHYLPYRIDINE 3-Bromopyridine-2,6-dicarboxylic acid

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  • 6-Chloro-4-methyl-4-pyridinecarboxylic acid
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  • 6-dimethylpyridine
  • 3-Bromo-2,6-dimethylpyridine CAS NO.3430-31-7
  • 3430-31-7
  • Pyridine
  • Heterocycle-Pyridine series
  • Pyridine Series