(R)-(-)-1-Cyclohexylethylamine Property

Melting point:

-15°C (estimate)

alpha 

-3.8 º (NEAT)

Boiling point:

177-178 °C (lit.)

Density 

0.866 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.463

Flash point:

126 °F

pka

10.89±0.29(Predicted)

form 

clear liquid

color 

Colorless to Almost colorless

optical activity

[α]20/D 4°, neat &_& [α]20/D -3.8±0.3°, neat

Water Solubility 

Miscible with acetone, chloroform,dimethyl sulfoxide, ethanol, methanol, ether, petroleum ether and dichloromethane. Insoluble in water.

Sensitive 

Air Sensitive

BRN 

2935070

CAS DataBase Reference

5913-13-3(CAS DataBase Reference)

NIST Chemistry Reference

R-(-)-Cyclohexylethylamine(5913-13-3)

Safety

Hazard Codes 

C

Risk Statements 

10-21/22-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2734 8/PG 2

WGK Germany 

3

F 

3-10-23

HazardClass 

8

PackingGroup 

II

HS Code 

2921309990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

(R)-(-)-1-Cyclohexylethylamine Chemical Properties,Usage,Production

Chemical Properties

optical purity >99% ee

Uses

(R)-(-)-1-Cyclohexylethylamine is used in the preparation of benzylidene(1-cyclohexylethyl)amine by reacting with benzaldehyde. It is also used to prepare chiral polymethacrylamides, which are employed as stationary phases for the liquid-chromatographic resolution of racemic amides. In addition to this, it is used in the preparation of polyamides bound to silica gel for high performance liquid chromatography, which are pressure-stable.

Uses

(R)-(-)-1-Cyclohexylethylamine may be used in the preparation of a chiral calix[4]arene Schiff base derivatives with potential enantioselective recognition ability towards amines.

General Description

(R)-(-)-1-Cyclohexylethylamine is a chiral amine mainly used as a resolving agent for racemic compounds.

Purification Methods

Purify it by conversion to the bitartrate salt (m 172o), then decomposing with strong alkali and extracting into Et2O, drying (KOH), filtering, evaporating and distilling. The hydrochloride salt has m 242o (from EtOH/Et2O), [] D -5.0o (c 10 H2O, from (+) amine). The oxalate salt has m 132o (from H2O). The (±)-base has b 176-178o/760mm, and HCl has m 237-238o. [Reihlen et al. Justus Liebigs Ann Chem 532 247 1938, Leithe Chem Ber 65 660 1932, Beilstein 12 III 95.]