Ethyl 2,3,4,5-tetrafluorobenzoyl acetate
- Product Name
- Ethyl 2,3,4,5-tetrafluorobenzoyl acetate
- CAS No.
- 94695-50-8
- Chemical Name
- Ethyl 2,3,4,5-tetrafluorobenzoyl acetate
- Synonyms
- SKL919;Ethyl 2;Levofloxacin-17;Levofloxacin Impurity V;5-tetrafluorobenzoyl acetate;Ethyl(2,3,4,5-tetrafluorobenzo;ethy-2,3,4,5-tetrafluorobenzoylacetate;ETHYL 2,3,4,5-TETRAFLUOROBENZOYL ACETATE;Methyl (2,3,4,5-Tetrafluoro-Benzoyl)Acetate;Ethyl(2,3,4,5-Tetrafluorobenzoyl)acetate>
- CBNumber
- CB2174431
- Molecular Formula
- C11H8F4O3
- Formula Weight
- 264.17
- MOL File
- 94695-50-8.mol
Ethyl 2,3,4,5-tetrafluorobenzoyl acetate Property
- Melting point:
- 41-44°C
- Boiling point:
- 100 °C / 0.1mmHg
- Density
- 1.384
- Flash point:
- 123℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO, Methanol
- form
- Solid
- pka
- 10.51±0.50(Predicted)
- color
- Off-White to Beige
- InChI
- InChI=1S/C11H8F4O3/c1-2-18-8(17)4-7(16)5-3-6(12)10(14)11(15)9(5)13/h3H,2,4H2,1H3
- InChIKey
- KWDVJYLIAJHEOW-UHFFFAOYSA-N
- SMILES
- C(OCC)(=O)CC(C1=CC(F)=C(F)C(F)=C1F)=O
- CAS DataBase Reference
- 94695-50-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- E0759
- Product name
- Ethyl (2,3,4,5-Tetrafluorobenzoyl)acetate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $72
- Updated
- 2025/07/31
- Product number
- 448791
- Product name
- Ethyl 2-
- Packaging
- 50mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 448786
- Product name
- Ethyl 2-
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 448710
- Product name
- Ethyl 2-
- Packaging
- 25mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 448700
- Product name
- Ethyl 2-
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
Ethyl 2,3,4,5-tetrafluorobenzoyl acetate Chemical Properties,Usage,Production
Chemical Properties
White or off-white crystal
Uses
2,3,4,5-Tetrafluorobenzoylacetic Acid Ethyl Ester is a fluorinated benzoylacetate used as a synthetic reagent in the preparation of antibacterial and potential antitumor agents.
Uses
Ethyl 2,3,4,5-tetrafluorobenzoyl acetate is a fluorinated benzoylacetate used as a synthetic reagent in the preparation of antibacterial and potential antitumor agents.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 24, p. 453, 1987 DOI: 10.1002/jhet.5570240228
Synthesis, p. 290, 1993 DOI: 10.1055/s-1993-25849
Synthesis
6148-64-7
94695-48-4
94695-50-8
General procedure for the synthesis of ethyl 3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate from monoethyl malonate potassium salt and tetrafluorobenzoyl chloride: monoethyl malonate potassium salt (3.66 g, 21.5 mmol), MgCl? (2.44 g, 25.7 mmol) and triethylamine (TEA, 2.05 g, 20.3 mmol) were dissolved in acetonitrile (70 mL) in acetonitrile (70 mL) and the reaction was stirred for 2.5 h at 10-15 °C. Subsequently, a solution of 2,3,4,5-tetrafluorobenzoyl chloride (2.00 g, 10.3 mmol) in acetonitrile (10 mL) was slowly added dropwise at 0 °C for a controlled time of 15 min. After dropwise addition, TEA (0.23 g, 2.3 mmol) was added again. The reaction mixture was gradually warmed to room temperature and stirring was continued for 16 hours. After completion of the reaction, the volatiles were evaporated under reduced pressure. Toluene (30 mL) was added and evaporated again under reduced pressure. Subsequently, toluene (60 mL) was added and 1.5 M HCl (40 mL) was carefully added, controlling the reaction temperature to not exceed 25°C. The reaction was carried out under reduced pressure. The organic phase was washed sequentially with 1.5 M HCl (2 x 25 mL) and water (2 x 25 mL), dried with MgSO? and finally concentrated under reduced pressure to give the target product ([M + 1]? 265, 99% yield).
References
[1] Patent: WO2008/131134, 2008, A1. Location in patent: Page/Page column 57-58
[2] Synthesis, 1993, # 3, p. 290 - 292
[3] Patent: US2006/63761, 2006, A1. Location in patent: Page/Page column 5; 10-11
[4] Chemical Communications, 2013, vol. 49, # 46, p. 5313 - 5315
Ethyl 2,3,4,5-tetrafluorobenzoyl acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 2,3,4,5-tetrafluorobenzoyl acetate Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
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View Lastest Price from Ethyl 2,3,4,5-tetrafluorobenzoyl acetate manufacturers
- Product
- Ethyl 2,3,4,5-tetrafluorobenzoyl acetate 94695-50-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98
- Supply Ability
- 10000KGS
- Release date
- 2025-11-12
- Product
- Ethyl 2,3,4,5-tetrafluorobenzoyl acetate 94695-50-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-05
- Product
- Ethyl 2,3,4,5-tetrafluorobenzoyl acetate 94695-50-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2022-09-22